ES2108614B1 - Vacunas polimerizadas. - Google Patents

Vacunas polimerizadas.

Info

Publication number
ES2108614B1
ES2108614B1 ES09401953A ES9401953A ES2108614B1 ES 2108614 B1 ES2108614 B1 ES 2108614B1 ES 09401953 A ES09401953 A ES 09401953A ES 9401953 A ES9401953 A ES 9401953A ES 2108614 B1 ES2108614 B1 ES 2108614B1
Authority
ES
Spain
Prior art keywords
proteins
kilo
daltons
concentrates
polymerization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09401953A
Other languages
English (en)
Other versions
ES2108614A1 (es
Inventor
Oncina Fco Javier Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to ES09401953A priority Critical patent/ES2108614B1/es
Priority to EP96922046A priority patent/EP0782860A1/en
Priority to PCT/ES1996/000145 priority patent/WO1997002838A1/es
Publication of ES2108614A1 publication Critical patent/ES2108614A1/es
Application granted granted Critical
Publication of ES2108614B1 publication Critical patent/ES2108614B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE HA DESARROLLADO UN METODO DE OBTENCION DE VACUNAS POLIMERIZADAS QUE CONSISTE EN LA POLIMERIZACION, ENTRE ELLAS DE LAS PROTEINAS ANTIGENICAS PRODUCIDAS EN UN PROCESO PATOLOGICO; LAS PROTEINAS A POLIMERIZAR SON LAS DE PESO MOLECULAR MENOR A 60 KILO-DALTONS (RANGO DE 60 A 70 KILO-DALTONS), DADO QUE SON INDUCTORAS DE RESPUESTAS LINFOCITARIAS DE TIPO TH2 (INMUNODEPRESORAS). LA POLIMERIZACION SE PUEDE REALIZAR POR SINTESIS GRADUAL, PROTEINA A PROTEINA, SIGUIENDO LOS FUNDAMENTOS DE LOS METODOS CLASICOS DE SINTESIS DE PEPTIDOS, O POR POLICONDENSACION (ES EL METODO DE ELECCION) MEDIANTE AGENTES ALQUILANTES, EN CONCENTRACION RESTRICTIVA, CON DOS GRUPOS ACTIVADOS CAPACES DE UNIR DOS PROTEINAS POR ENLACE SOBRE SUS GRUPOS AMINO. LOS POLIMEROS OBTENIDOS SE SELECCIONAN MEDIANTE LAS TECNICAS DE FRACCIONAMIENTO EN COLUMNA MEDIANTE TAMICES MOLECULARES; LOS POLIMEROS RESULTANTES PROVOCAN UNA RESPUESTA ANTIGENICA SIMILAR A LAS PROTEINAS QUE LO COMPONEN, PERO BAJO CONTROL DE LOS LINFOCITOS TH1 (INMUNOPOTENCIADORES).
ES09401953A 1995-07-12 1995-07-12 Vacunas polimerizadas. Expired - Lifetime ES2108614B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES09401953A ES2108614B1 (es) 1995-07-12 1995-07-12 Vacunas polimerizadas.
EP96922046A EP0782860A1 (en) 1995-07-12 1996-07-10 Polymerized vaccines
PCT/ES1996/000145 WO1997002838A1 (es) 1995-07-12 1996-07-10 Vacunas polimerizadas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09401953A ES2108614B1 (es) 1995-07-12 1995-07-12 Vacunas polimerizadas.

Publications (2)

Publication Number Publication Date
ES2108614A1 ES2108614A1 (es) 1997-12-16
ES2108614B1 true ES2108614B1 (es) 1998-07-16

Family

ID=8287454

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09401953A Expired - Lifetime ES2108614B1 (es) 1995-07-12 1995-07-12 Vacunas polimerizadas.

Country Status (3)

Country Link
EP (1) EP0782860A1 (es)
ES (1) ES2108614B1 (es)
WO (1) WO1997002838A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329157B1 (en) 1998-05-28 2001-12-11 Abbott Laboratories Antigen cocktails and uses thereof
CA2333598C (en) * 1998-05-28 2009-10-13 Abbott Laboratories Toxoplasma gondii antigens, p35, and uses thereof
LT2875828T (lt) * 2012-07-20 2019-07-25 Diater, Laboratorio de Diagnostico y Aplicaciones TerapĆ©uticas, S.A. Kompozicijos, skirtos polimerintų alergenų intraderminiam įvedimui

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545863A1 (de) * 1965-09-30 1969-12-11 Hoechst Ag Verfahren zur Herstellung von vernetzten Proteinen und Peptiden
US4526716A (en) * 1981-11-20 1985-07-02 The Ohio State University Antigenic modification of polypeptides
US4180562A (en) * 1973-05-08 1979-12-25 Northwestern University Glutaraldehyde polymerized ragweed antigen E preparation for treatment of allergic patients sensitive to ragweed pollen
FR2270891A2 (en) * 1974-05-15 1975-12-12 Anvar Vaccines by glutaraldehyde detoxification - especially multivalent vaccines e.g. against tetanus and diphtheria
ES2013359A6 (es) * 1988-11-04 1990-05-01 Corporacion Biolog Farmaceutic Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados.
FR2695563B1 (fr) * 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.

Also Published As

Publication number Publication date
ES2108614A1 (es) 1997-12-16
WO1997002838A1 (es) 1997-01-30
EP0782860A1 (en) 1997-07-09

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