ES2013359A6 - Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados. - Google Patents
Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados.Info
- Publication number
- ES2013359A6 ES2013359A6 ES8803356A ES8803356A ES2013359A6 ES 2013359 A6 ES2013359 A6 ES 2013359A6 ES 8803356 A ES8803356 A ES 8803356A ES 8803356 A ES8803356 A ES 8803356A ES 2013359 A6 ES2013359 A6 ES 2013359A6
- Authority
- ES
- Spain
- Prior art keywords
- polymerized
- molecular weight
- procedure
- production
- allergenis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 230000002009 allergenic effect Effects 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA FABRICACION DE ALERGENOS INMUNOGENICOS POLIMERIZADOS. PROCEDIMIENTO PARA LA FABRICACION DE ALERGENOS INMUNOGENICOS POLIMERIZADOS Y CON ENLACES TRANSVERSALES (<CROSS-LINKED>) PARA EL TRATAMIENTO CLINICO DE ALERGIAS. LOS COMPONENTES ALERGENOS DE ELEVADO PESO MOLECULAR SON POLIMERIZADOS CON GLUTARDIALDEHIDO. LA REACCION SE DETIENE POR ADICION DE GLICINA U OTROS AMINOACIDOS O AMINAS PRIMARIAS. LOS PRODUCTOS DE REACCION CON PESO MOLECULAR INFERIOR A 100.000 DALTONS SE ELIMINAN POR FILTRACION MOLECULAR, DIALISIS O TAMIZADO. LOS COMPONENTES CON PESO MOLECULAR SUPERIOR A 100.000 DALTONS SE CONCENTRAN Y GUARDAN CONGELADOS EN SOLUCION O LIOFILIZACION EN ESTADO DOLISO.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8803356A ES2013359A6 (es) | 1988-11-04 | 1988-11-04 | Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados. |
| EP19890200116 EP0367306A3 (en) | 1988-11-04 | 1989-01-19 | Procedure for polymerized allergenis production |
| JP1103312A JPH02138130A (ja) | 1988-11-04 | 1989-04-21 | 重合されたアレルゲンの製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES8803356A ES2013359A6 (es) | 1988-11-04 | 1988-11-04 | Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2013359A6 true ES2013359A6 (es) | 1990-05-01 |
Family
ID=8258799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8803356A Expired - Lifetime ES2013359A6 (es) | 1988-11-04 | 1988-11-04 | Procedimiento para la fabricacion de alergenos inmunogenicos polimerizados. |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0367306A3 (es) |
| JP (1) | JPH02138130A (es) |
| ES (1) | ES2013359A6 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5328991A (en) * | 1989-11-03 | 1994-07-12 | Immulogic Pharmaceutical Corp. | Preparation of alkali-modified cat dander allergen (Fel d I) for immunotherapeutic purposes |
| US5547669A (en) * | 1989-11-03 | 1996-08-20 | Immulogic Pharma Corp | Recombinant peptides comprising T cell epitopes of the cat allergen, Fel d I |
| US5091318A (en) * | 1990-04-13 | 1992-02-25 | Abbott Laboratories | Binding of allergens to a solid phase |
| IL103456A (en) * | 1991-10-16 | 2006-06-11 | Merck Patent Gmbh | Isolated peptides having t-cell stimulating activity |
| GB9508785D0 (en) * | 1995-04-29 | 1995-06-21 | Smithkline Beecham Plc | Novel compositions |
| ES2108614B1 (es) * | 1995-07-12 | 1998-07-16 | Oncina Fco Javier Martin | Vacunas polimerizadas. |
| PL187544B1 (pl) | 1997-10-30 | 2004-07-30 | C B F Leti Sa | Wywołujące tolerancję fragmenty naturalnych alergenów |
| BRPI0815395A2 (pt) | 2007-08-15 | 2015-02-10 | Circassia Ltd | Composição, vetor, produto, formulação farmacêutica, me´todo in vitro para determinar se as células t reconhecem um polipeptídeo, e, método in vitro para determinar se um indivíduo se encontra ou está em risco de uma condição. |
| AU2011214316B2 (en) * | 2010-02-12 | 2015-07-02 | Laboratorios Leti, S.L. | Process for producing an allergen extract |
| GB201106802D0 (en) * | 2011-04-21 | 2011-06-01 | Allergy Therapeutics Ltd | Process for preparing vaccine composition |
-
1988
- 1988-11-04 ES ES8803356A patent/ES2013359A6/es not_active Expired - Lifetime
-
1989
- 1989-01-19 EP EP19890200116 patent/EP0367306A3/en not_active Withdrawn
- 1989-04-21 JP JP1103312A patent/JPH02138130A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0367306A2 (en) | 1990-05-09 |
| JPH02138130A (ja) | 1990-05-28 |
| EP0367306A3 (en) | 1990-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2008-11-04 |