ES2109731T3 - Procedimiento para producir acidos n-amino-1-hidroxi-alquiliden-1,1-bisfosfonicos. - Google Patents

Procedimiento para producir acidos n-amino-1-hidroxi-alquiliden-1,1-bisfosfonicos.

Info

Publication number
ES2109731T3
ES2109731T3 ES94927234T ES94927234T ES2109731T3 ES 2109731 T3 ES2109731 T3 ES 2109731T3 ES 94927234 T ES94927234 T ES 94927234T ES 94927234 T ES94927234 T ES 94927234T ES 2109731 T3 ES2109731 T3 ES 2109731T3
Authority
ES
Spain
Prior art keywords
amino
alkyliden
hydroxy
procedure
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94927234T
Other languages
English (en)
Inventor
Richard R Dauer
Lisa Dimichele
Mauricio Futran
Gerard R Kieczykowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27381051&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2109731(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2109731T3 publication Critical patent/ES2109731T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCESO PARA LA PRODUCCION CONTINUA DE ALQUILPIROFOSFONATO, ALQUILPIROFOSFATO Y MULTIMEROS DE LOS MISMOS Y PARA LA PRODUCCION DE ACIDOS 4-AMINO-1-HIDROXIALQUILIDEN-1,1-BISFOSFONICOS O SALES DE LOS MISMOS.
ES94927234T 1993-08-25 1994-08-24 Procedimiento para producir acidos n-amino-1-hidroxi-alquiliden-1,1-bisfosfonicos. Expired - Lifetime ES2109731T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11175193A 1993-08-25 1993-08-25
US23964094A 1994-05-09 1994-05-09
US08/286,151 US5510517A (en) 1993-08-25 1994-08-04 Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

Publications (1)

Publication Number Publication Date
ES2109731T3 true ES2109731T3 (es) 1998-01-16

Family

ID=27381051

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94927234T Expired - Lifetime ES2109731T3 (es) 1993-08-25 1994-08-24 Procedimiento para producir acidos n-amino-1-hidroxi-alquiliden-1,1-bisfosfonicos.

Country Status (24)

Country Link
US (1) US5510517A (es)
EP (1) EP0715631B1 (es)
JP (1) JP3675818B2 (es)
KR (1) KR100261202B1 (es)
CN (2) CN1067079C (es)
AT (1) ATE160352T1 (es)
AU (2) AU692468B2 (es)
BR (1) BR9407563A (es)
CA (1) CA2169561C (es)
CY (1) CY2086B1 (es)
CZ (1) CZ290185B6 (es)
DE (1) DE69406936T2 (es)
DK (1) DK0715631T3 (es)
ES (1) ES2109731T3 (es)
FI (1) FI115526B (es)
GR (1) GR3025450T3 (es)
HR (1) HRP940479B1 (es)
HU (1) HU217362B (es)
LV (1) LV12189B (es)
NZ (1) NZ273458A (es)
RO (1) RO115524B1 (es)
RU (1) RU2154647C2 (es)
SI (1) SI0715631T1 (es)
WO (1) WO1995006052A1 (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449819A (en) * 1994-06-06 1995-09-12 Merck & Co., Inc. Process for removing waste pox, alendronate and its by products
US5589691A (en) * 1994-06-06 1996-12-31 Merck & Co., Inc. Process for recovery and recycle of methanesulfonic acid and phosphorous acid
CZ116999A3 (cs) * 1996-10-04 1999-09-15 Merck And Co., Inc. Vodný tekutý farmaceutický prostředek
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
GB9800452D0 (en) * 1998-01-10 1998-03-04 Albright & Wilson Preparation of phosphonic acid derivatives
US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
WO1999067809A1 (en) 1998-06-24 1999-12-29 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
KR20140021045A (ko) * 2002-05-10 2014-02-19 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
AU2003233569A1 (en) * 2002-05-17 2003-12-02 Teva Pharmaceutical Industries Ltd. Use of certain diluents for making bisphosphonic acids
EP1513523A1 (en) * 2002-06-06 2005-03-16 Merck Frosst Canada & Co. 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
CA2495917A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
US7449499B2 (en) * 2003-08-12 2008-11-11 3M Innovative Properties Company Self-etching dental compositions and methods
JP4553899B2 (ja) 2003-08-21 2010-09-29 メルク フロスト カナダ リミテツド カテプシンシステインプロテアーゼ阻害剤
KR20060058134A (ko) * 2003-09-19 2006-05-29 화이자 프로덕츠 인코포레이티드 2-알킬리덴-19-노르-비타민 디 유도체 및비스포스포네이트의 조합을 포함하는 약학 조성물 및 방법
US7342060B2 (en) * 2003-12-11 2008-03-11 Dover Chemical Corporation Process for manufacture of pentaerythritol diphosphites
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
US8465284B2 (en) * 2004-07-08 2013-06-18 3M Innovative Properties Company Dental methods, compositions, and kits including acid-sensitive dyes
US8722760B2 (en) * 2004-08-11 2014-05-13 3M Innovative Properties Company Self-adhesive compositions including a plurality of acidic compounds
US8722734B2 (en) 2005-03-02 2014-05-13 Merck Sharp & Dohme Corp. Composition for inhibition of cathepsin K
CA2606879A1 (en) * 2005-05-06 2007-03-01 Medichem, S.A. Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof
US8003820B2 (en) 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
AR058168A1 (es) * 2005-11-07 2008-01-23 Merck & Co Inc Sintesis del alendronato de sodio trihidratado
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
WO2007096896A1 (en) * 2006-02-20 2007-08-30 Alembic Limited An improved process for the preparation of biphosphonic derivatives
CN101557791B (zh) 2006-12-13 2013-05-22 3M创新有限公司 使用具有酸性组分和可光漂白染料的牙科用组合物的方法
CA2689504A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
JP5539221B2 (ja) 2007-12-21 2014-07-02 リガンド・ファーマシューティカルズ・インコーポレイテッド 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）およびその使用
WO2010003704A2 (en) 2008-07-11 2010-01-14 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
EP2192126B1 (en) 2008-11-26 2013-03-27 Synthon B.V. Process for making zoledronic acid
WO2011023280A1 (en) 2009-08-28 2011-03-03 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
CN102630227B (zh) * 2009-10-26 2016-03-23 沃纳奇尔科特有限责任公司 用于治疗骨代谢紊乱的双膦酸盐化合物
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
ES2716525T3 (es) 2010-12-06 2019-06-13 Effrx Pharmaceuticals Sa Formulaciones de bisfosfonatos efervescentes estables con características de solubilización rápida
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
FI20115315A0 (fi) * 2011-04-01 2011-04-01 Itae Suomen Yliopisto Menetelmä metallien keräämiseksi
CA2923272A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
ES2864079T3 (es) 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
US10400000B2 (en) 2015-06-12 2019-09-03 Simon Fraser University Amide-linked EP4 agonist-bisphosphonate compounds and uses thereof
WO2020019108A1 (en) 2018-07-23 2020-01-30 Guangzhou Othrotx Co., Ltd. Bisphosphonate drug conjugates
CN109456363A (zh) * 2018-11-01 2019-03-12 南京海纳医药科技股份有限公司 一种米诺膦酸工艺杂质的制备方法
KR20220003554A (ko) 2019-04-19 2022-01-10 리간드 파마슈티칼스 인코포레이티드 화합물의 결정질 형태 및 결정질 형태를 제조하는 방법
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DD216465A1 (de) * 1983-07-01 1984-12-12 Agrochemie Piesteritz 4602 Wit Verfahren zur herstellung substituierter alkanphosphonsaeuren
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof

Also Published As

Publication number Publication date
EP0715631A1 (en) 1996-06-12
AU7674394A (en) 1995-03-21
CZ290185B6 (cs) 2002-06-12
CA2169561C (en) 2007-02-20
HRP940479A2 (en) 1997-02-28
RU2154647C2 (ru) 2000-08-20
CY2086B1 (en) 2002-04-05
WO1995006052A1 (en) 1995-03-02
GR3025450T3 (en) 1998-02-27
ATE160352T1 (de) 1997-12-15
JPH09501935A (ja) 1997-02-25
HK1008883A1 (en) 1999-05-21
DE69406936D1 (de) 1998-01-02
JP3675818B2 (ja) 2005-07-27
CZ54296A3 (en) 1996-10-16
RO115524B1 (ro) 2000-03-30
FI960851L (fi) 1996-02-23
CN1067079C (zh) 2001-06-13
BR9407563A (pt) 1996-12-31
KR100261202B1 (ko) 2000-07-01
DK0715631T3 (da) 1997-12-22
CN1211392C (zh) 2005-07-20
CA2169561A1 (en) 1995-03-02
CN1308082A (zh) 2001-08-15
NZ273458A (en) 1998-04-27
FI115526B (fi) 2005-05-31
HUT75261A (en) 1997-05-28
AU714996B2 (en) 2000-01-13
SI0715631T1 (en) 1998-02-28
FI960851A0 (fi) 1996-02-23
EP0715631B1 (en) 1997-11-19
DE69406936T2 (de) 1998-06-04
HU9600429D0 (en) 1996-04-29
LV12189A (lv) 1998-12-20
HRP940479B1 (en) 2000-10-31
AU692468B2 (en) 1998-06-11
LV12189B (en) 1999-02-20
HU217362B (hu) 2000-01-28
US5510517A (en) 1996-04-23
CN1134703A (zh) 1996-10-30
AU7993798A (en) 1998-10-15

Similar Documents

Publication Publication Date Title
BR9407563A (pt) Composto e processo para a produçao continua do mesmo
IS4147A (is) Aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum
BR9000640A (pt) Processo para producao de um artigo termoplastico
BR9103948A (pt) Processo para a producao de polimeros de estireno expandiveis
BR8906363A (pt) Processo para producao de tricloromonosilano
BR9406236A (pt) Processo para a produção de difluoro-metano
BR9203799A (pt) Processo para a producao de diritromicina
BR9103885A (pt) Processo para a producao de latex estavel
BR9205090A (pt) Processo para producao de duas correntes continuas de cigarros
BR8807555A (pt) Processo de producao de filamento de metal e aparelho para materializacao do dito processo
BR8900945A (pt) Processo para a producao de cloro
PT90353A (pt) Processo para a producao de polipeptideos
BR8904840A (pt) Processo para producao de n-fosfonometilglicina
BR9306515A (pt) Processo para a produção de hidrofluoroalcanos
BR9607227A (pt) Método para a produção de um catalisador pré-polimerizado
BR9002408A (pt) Processo para a producao de poliarilatos
BR9203843A (pt) Processo para producao de octadienois e complexo de bis(fosfina)paladio
BR9101662A (pt) Processo para a producao de 1,4-butanodiol
BR9005385A (pt) Processo para a producao de 1,1-diclorotetrafluoretano
BR9303969A (pt) Processo para produção de ácidos 2-arilbenzimidazol-5-sulfônicos
BR9602904A (pt) Processo para a produção de nacos de carne
BR8800160A (pt) Processo para a producao de 2,2',4,4',6,6'-hexanitro estilbeno
ITRM930141A0 (it) Procedimento per la produzione di perfluoroalchilsolfonilfloruri.
BR9600086A (pt) Processo para a produção de hidroxialcoxibenzofenonas
IS4707A (is) Aðferð til framleiðslu á díoxóazabísýklóhexönum

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 715631

Country of ref document: ES