ES2109747T3 - Derivados de acidos biliares utiles en la terapia de la calculosis biliar de colesterol y de las patologias causadas por colestasis. - Google Patents
Derivados de acidos biliares utiles en la terapia de la calculosis biliar de colesterol y de las patologias causadas por colestasis.Info
- Publication number
- ES2109747T3 ES2109747T3 ES95103320T ES95103320T ES2109747T3 ES 2109747 T3 ES2109747 T3 ES 2109747T3 ES 95103320 T ES95103320 T ES 95103320T ES 95103320 T ES95103320 T ES 95103320T ES 2109747 T3 ES2109747 T3 ES 2109747T3
- Authority
- ES
- Spain
- Prior art keywords
- cholesterol
- therapy
- derivatives
- cholestasis
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 5
- 208000015924 Lithiasis Diseases 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 206010008635 Cholestasis Diseases 0.000 title 1
- 230000007870 cholestasis Effects 0.000 title 1
- 231100000359 cholestasis Toxicity 0.000 title 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 abstract 2
- 201000003883 Cystic fibrosis Diseases 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000010235 enterohepatic circulation Effects 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 230000000366 juvenile effect Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229960003080 taurine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
SE PRESENTAN AMIDOS DE ACIDOS URSODEOXICOLICOS, HIOCOLICOS E HIODEOXICOLICOS CON AMINOACIDOS CICLICOS DE LA FORMULA GENERAL I ASI COMO SUS SALES ORGANICAS E INORGANICAS FARMACOLOGICAMENTE ACEPTABLES. ESTOS AMIDOS MUESTRAN UNA ESTABILIDAD METABOLICA, TANTO ENTERICA COMO HEPATICA, MAYOR QUE LA DE LOS ACIDOS CORRESPONDIENTES DE LA BILIS, CON GLICINA O TAURINA FISIOLOGICAMENTE PRESENTE EN LA CIRCULACION ENTEROHEPATICA. LA ACTIVIDAD FARMACOLOGICA DE LOS DERIVADOS DE LA FORMULA I Y DE SUS SALES ORGANICAS E INORGANICAS FARMACOLOGICAMENTE ACEPTABLES HACE SU USO EFICAZ EN LA TERAPIA DE LA CALCULOSIS BILIAR PRODUCIDA POR EL COLESTEROL Y EN CUALQUIER PATOLOGIA PROVOCADA POR LA COLESTASIS TAL COMO LA HEPATITIS CRONICA PRODUCIDA POR COLESTASIS, LA CIRROSIS BILIAR PRIMITIVA Y LA HEPATOTIA JUVENIL UNIDA A LA FIBROSIS CISTICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITBO940146A IT1274000B (it) | 1994-04-06 | 1994-04-06 | Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2109747T3 true ES2109747T3 (es) | 1998-01-16 |
Family
ID=11339676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95103320T Expired - Lifetime ES2109747T3 (es) | 1994-04-06 | 1995-03-08 | Derivados de acidos biliares utiles en la terapia de la calculosis biliar de colesterol y de las patologias causadas por colestasis. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5639744A (es) |
| EP (1) | EP0676410B1 (es) |
| AT (1) | ATE160785T1 (es) |
| DE (1) | DE69501125T2 (es) |
| DK (1) | DK0676410T3 (es) |
| ES (1) | ES2109747T3 (es) |
| GR (1) | GR3025811T3 (es) |
| IT (1) | IT1274000B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1158989B1 (en) * | 1999-03-09 | 2007-06-20 | Anker, Stefan | Use of inhibitors of endotoxin for the treatment of cachexia |
| CN1187364C (zh) | 1999-04-30 | 2005-02-02 | 亚其发展公司 | 类固醇衍生物 |
| DE19941764A1 (de) * | 1999-09-02 | 2001-03-15 | Aventis Pharma Gmbh | Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente |
| SK3862002A3 (en) * | 1999-09-22 | 2003-01-09 | Aventis Pharma Gmbh | 4-Benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use |
| EP1385868A4 (en) * | 2001-02-08 | 2004-12-08 | Univ Chicago | STEROID DERIVATIVE |
| US20070197484A1 (en) * | 2001-05-03 | 2007-08-23 | Ching Song | Method of treating disorder related to high cholesterol concentration |
| JP4309661B2 (ja) * | 2001-05-03 | 2009-08-05 | ザ ユニバーシティー オブ シカゴ | 肝臓ｘ受容体 |
| US7078396B2 (en) * | 2001-05-03 | 2006-07-18 | Arch Development Corporation | Method of treating disorder related to high cholesterol concentration |
| US7053076B2 (en) | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| WO2003086303A2 (en) * | 2002-04-12 | 2003-10-23 | The University Of Chicago | Farnesoid x-activated receptor agonists |
| EP2301919A1 (en) * | 2004-06-10 | 2011-03-30 | Board of Trustees of Michigan State University | Synthesis of caprolactam from lysine |
| US20070032464A1 (en) * | 2004-10-08 | 2007-02-08 | Shutsung Liao | Methods of treating cancers |
| CN101541746B (zh) * | 2007-02-20 | 2013-01-02 | 密执安州立大学董事会 | 用于生产己内酰胺的催化脱氨基 |
| WO2010011967A1 (en) * | 2008-07-24 | 2010-01-28 | Draths Corporation | Methods of making cyclic amide monomers, and related derivatives and methods |
| US8829213B2 (en) * | 2009-07-29 | 2014-09-09 | The University Of Chicago | Liver X receptor agonists |
-
1994
- 1994-04-06 IT ITBO940146A patent/IT1274000B/it active IP Right Grant
-
1995
- 1995-03-08 DK DK95103320.8T patent/DK0676410T3/da active
- 1995-03-08 DE DE69501125T patent/DE69501125T2/de not_active Expired - Fee Related
- 1995-03-08 EP EP95103320A patent/EP0676410B1/en not_active Expired - Lifetime
- 1995-03-08 ES ES95103320T patent/ES2109747T3/es not_active Expired - Lifetime
- 1995-03-08 AT AT95103320T patent/ATE160785T1/de active
- 1995-04-04 US US08/416,155 patent/US5639744A/en not_active Expired - Fee Related
-
1997
- 1997-12-30 GR GR970403460T patent/GR3025811T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3025811T3 (en) | 1998-03-31 |
| EP0676410B1 (en) | 1997-12-03 |
| ITBO940146A1 (it) | 1995-10-06 |
| DE69501125T2 (de) | 1998-03-26 |
| EP0676410A3 (en) | 1995-12-27 |
| US5639744A (en) | 1997-06-17 |
| DK0676410T3 (da) | 1998-05-04 |
| DE69501125D1 (de) | 1998-01-15 |
| ITBO940146A0 (it) | 1994-04-06 |
| EP0676410A2 (en) | 1995-10-11 |
| IT1274000B (it) | 1997-07-14 |
| ATE160785T1 (de) | 1997-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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