IT1274000B - Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi - Google Patents

Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi

Info

Publication number: IT1274000B
Authority: IT; Italy
Prior art keywords: biliary; cholestasis; cholesterol; therapy; chalculosis
Prior art date: 1994-04-06

Application number

ITBO940146A

Other languages

English (en)

Inventor

Egidio Marchi

Maria Rita Milani

Silvano Piani

Aldo Roda

Gianfranco Cainelli

Original Assignee

Alfa Wassermann Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-04-06

Filing date

1994-04-06

Publication date

1997-07-14

1994-04-06 Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa

1994-04-06 Publication of ITBO940146A0 publication Critical patent/ITBO940146A0/it

1994-04-06 Priority to ITBO940146A priority Critical patent/IT1274000B/it

1995-03-08 Priority to EP95103320A priority patent/EP0676410B1/en

1995-03-08 Priority to ES95103320T priority patent/ES2109747T3/es

1995-03-08 Priority to DK95103320.8T priority patent/DK0676410T3/da

1995-03-08 Priority to DE69501125T priority patent/DE69501125T2/de

1995-03-08 Priority to AT95103320T priority patent/ATE160785T1/de

1995-04-04 Priority to US08/416,155 priority patent/US5639744A/en

1995-10-06 Publication of ITBO940146A1 publication Critical patent/ITBO940146A1/it

1997-07-14 Application granted granted Critical

1997-07-14 Publication of IT1274000B publication Critical patent/IT1274000B/it

1997-12-30 Priority to GR970403460T priority patent/GR3025811T3/el

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
206010008635 Cholestasis Diseases 0.000 title abstract 3
231100000359 cholestasis Toxicity 0.000 title abstract 3
230000007870 cholestasis Effects 0.000 title abstract 3
239000003613 bile acid Substances 0.000 title abstract 2
235000012000 cholesterol Nutrition 0.000 title abstract 2
238000002560 therapeutic procedure Methods 0.000 title abstract 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
150000001408 amides Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 abstract 2
208000008439 Biliary Liver Cirrhosis Diseases 0.000 abstract 1
206010004659 Biliary cirrhosis Diseases 0.000 abstract 1
206010008909 Chronic Hepatitis Diseases 0.000 abstract 1
201000003883 Cystic fibrosis Diseases 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
208000015924 Lithiasis Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
-1 cyclic aminoacids Chemical class 0.000 abstract 1
230000010235 enterohepatic circulation Effects 0.000 abstract 1
230000002440 hepatic effect Effects 0.000 abstract 1
208000006454 hepatitis Diseases 0.000 abstract 1
230000000366 juvenile effect Effects 0.000 abstract 1
208000019423 liver disease Diseases 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
229960003080 taurine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

ITBO940146A 1994-04-06 1994-04-06 Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi IT1274000B (it)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
ITBO940146A IT1274000B (it)	1994-04-06	1994-04-06	Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi
DE69501125T DE69501125T2 (de)	1994-04-06	1995-03-08	Gallensäurederivate zur Behandlung von Gallenwegsteinen von Cholesterin und davon verursauchte Pathologien
ES95103320T ES2109747T3 (es)	1994-04-06	1995-03-08	Derivados de acidos biliares utiles en la terapia de la calculosis biliar de colesterol y de las patologias causadas por colestasis.
DK95103320.8T DK0676410T3 (da)	1994-04-06	1995-03-08	Galdesyrederivater, som er nyttige til terapi af galdesten på grund af cholesterol og af de patologier, der forårsages af cholestasis
EP95103320A EP0676410B1 (en)	1994-04-06	1995-03-08	Bile acids derivatives useful in the therapy of the biliary calculosis from cholesterol and of the pathologies caused by cholestasis
AT95103320T ATE160785T1 (de)	1994-04-06	1995-03-08	Gallensäurederivate zur behandlung von gallenwegsteinen von cholesterin und davon verursauchte pathologien
US08/416,155 US5639744A (en)	1994-04-06	1995-04-04	Bile acids derivatives useful in the therapy of the biliary calculosis from cholesterol and of the pathologies caused by cholestasis
GR970403460T GR3025811T3 (en)	1994-04-06	1997-12-30	Bile acids derivatives useful in the therapy of the biliary calculosis from cholesterol and of the pathologies caused by cholestasis.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITBO940146A IT1274000B (it)	1994-04-06	1994-04-06	Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi

Publications (3)

Publication Number	Publication Date
ITBO940146A0 ITBO940146A0 (it)	1994-04-06
ITBO940146A1 ITBO940146A1 (it)	1995-10-06
IT1274000B true IT1274000B (it)	1997-07-14

Family

ID=11339676

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITBO940146A IT1274000B (it)	1994-04-06	1994-04-06	Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi

Country Status (8)

Country	Link
US (1)	US5639744A (it)
EP (1)	EP0676410B1 (it)
AT (1)	ATE160785T1 (it)
DE (1)	DE69501125T2 (it)
DK (1)	DK0676410T3 (it)
ES (1)	ES2109747T3 (it)
GR (1)	GR3025811T3 (it)
IT (1)	IT1274000B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1212064A2 (en) *	1999-03-09	2002-06-12	Max-Delbrück-Centrum Für Molekulare Medizin	Use of inhibitors of endotoxin for the treatment of heart failure and of cachexia
JP2002543216A (ja)	1999-04-30	2002-12-17	アーチディベロップメントコーポレイション	ステロイド誘導体
DE19941764A1 (de) *	1999-09-02	2001-03-15	Aventis Pharma Gmbh	Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
WO2001021642A1 (de) *	1999-09-22	2001-03-29	Aventis Pharma Deutschland Gmbh	4-benzylaminochinoline konjugaten mit gallensaeure und ihre heteroanalogen, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und deren anwendung
WO2002062302A2 (en) *	2001-02-08	2002-08-15	The University Of Chicago	Steroidal derivatives
JP4309661B2 (ja) *	2001-05-03	2009-08-05	ザユニバーシティーオブシカゴ	肝臓ｘ受容体
US7078396B2 (en) *	2001-05-03	2006-07-18	Arch Development Corporation	Method of treating disorder related to high cholesterol concentration
US20070197484A1 (en) *	2001-05-03	2007-08-23	Ching Song	Method of treating disorder related to high cholesterol concentration
US7053076B2 (en)	2001-08-29	2006-05-30	Xenoport, Inc.	Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
AU2003228485A1 (en) *	2002-04-12	2003-10-27	The University Of Chicago	Farnesoid x-activated receptor agonists
BRPI0510746A (pt) *	2004-06-10	2007-11-20	Univ Michigan State	sìntese de caprolactama a partir de lisina
US20070032464A1 (en) *	2004-10-08	2007-02-08	Shutsung Liao	Methods of treating cancers
JP5410996B2 (ja) *	2007-02-20	2014-02-05	ボードオブトラスティーズオブミシガンステイトユニバーシティ	カプロラクタム製造のための触媒的脱アミノ化
EP2318373A1 (en) *	2008-07-24	2011-05-11	Draths Corporation	Methods of making cyclic amide monomers, and related derivatives and methods
JP2013500986A (ja) *	2009-07-29	2013-01-10	ザ・ユニバーシティ・オブ・シカゴ	肝臓ｘ受容体アゴニスト

1994
- 1994-04-06 IT ITBO940146A patent/IT1274000B/it active IP Right Grant
1995
- 1995-03-08 ES ES95103320T patent/ES2109747T3/es not_active Expired - Lifetime
- 1995-03-08 DK DK95103320.8T patent/DK0676410T3/da active
- 1995-03-08 EP EP95103320A patent/EP0676410B1/en not_active Expired - Lifetime
- 1995-03-08 AT AT95103320T patent/ATE160785T1/de active
- 1995-03-08 DE DE69501125T patent/DE69501125T2/de not_active Expired - Fee Related
- 1995-04-04 US US08/416,155 patent/US5639744A/en not_active Expired - Fee Related
1997
- 1997-12-30 GR GR970403460T patent/GR3025811T3/el unknown

Also Published As

Publication number	Publication date
EP0676410A3 (en)	1995-12-27
US5639744A (en)	1997-06-17
DE69501125T2 (de)	1998-03-26
ITBO940146A0 (it)	1994-04-06
ITBO940146A1 (it)	1995-10-06
EP0676410A2 (en)	1995-10-11
GR3025811T3 (en)	1998-03-31
DK0676410T3 (da)	1998-05-04
ES2109747T3 (es)	1998-01-16
EP0676410B1 (en)	1997-12-03
DE69501125D1 (de)	1998-01-15
ATE160785T1 (de)	1997-12-15

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Legal Events

Date	Code	Title	Description
1997-07-14	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970423