ES2110008T3 - Dermatan sulfato que posee una actividad trombolitica y formulaciones farmaceuticas que lo contienen - Google Patents
Dermatan sulfato que posee una actividad trombolitica y formulaciones farmaceuticas que lo contienenInfo
- Publication number
- ES2110008T3 ES2110008T3 ES92916443T ES92916443T ES2110008T3 ES 2110008 T3 ES2110008 T3 ES 2110008T3 ES 92916443 T ES92916443 T ES 92916443T ES 92916443 T ES92916443 T ES 92916443T ES 2110008 T3 ES2110008 T3 ES 2110008T3
- Authority
- ES
- Spain
- Prior art keywords
- activity
- sulfate
- thrombolitic
- possesses
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229920000045 Dermatan sulfate Polymers 0.000 abstract 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 abstract 1
- 229940051593 dermatan sulfate Drugs 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 229920001542 oligosaccharide Polymers 0.000 abstract 1
- 150000002482 oligosaccharides Chemical class 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN SULFATO DE DERMATAN NATURAL QUE POSEE UNA ACTIVIDAD ANTITROMBINICA EN EXCESO DE 200 U/MG, Y QUE SE CARACTERIZA PORQUE SE COMPONE DE UNA SECUENCIA DE OLIGOSACARIDOS CON UN ALTO GRADO DE SULFATACION, QUE TIENE LA FORMULA (III) EN LA QUE: N = ENTEROS 1 O 2; R4 = SO3 CO; I URONICO, EXTRAIDO DE ORGANOS Y PURIFICADO POSTERIORMENTE BAJO CONDICIONES DE TRATAMIENTO SUAVES, A UN PH ENTRE 5 Y 7 O EN CUALQUIER CASO INFERIOR A 7, LLEVANDOSE A CABO LA SEPARACION Y FRACCIONAMIENTO CON RESINAS INTERCAMBIADORAS DE IONES MACRORRETICULARES QUE TIENE UN TAMAÑO DE PARTICULA DE 0,3 A 1,3 MM, E INCLUSO INFERIOR A 10 (MU).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI912310A IT1251183B (it) | 1991-08-28 | 1991-08-28 | Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2110008T3 true ES2110008T3 (es) | 1998-02-01 |
Family
ID=11360588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92916443T Expired - Lifetime ES2110008T3 (es) | 1991-08-28 | 1992-08-06 | Dermatan sulfato que posee una actividad trombolitica y formulaciones farmaceuticas que lo contienen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5547944A (es) |
| EP (1) | EP0600928B1 (es) |
| JP (1) | JP3279316B2 (es) |
| KR (1) | KR100233338B1 (es) |
| AT (1) | ATE160149T1 (es) |
| AU (1) | AU2396292A (es) |
| CA (1) | CA2116437A1 (es) |
| DE (1) | DE69223153T2 (es) |
| DK (1) | DK0600928T3 (es) |
| ES (1) | ES2110008T3 (es) |
| IT (1) | IT1251183B (es) |
| WO (1) | WO1993005074A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707604A (en) * | 1986-11-18 | 1998-01-13 | Access Pharmaceuticals, Inc. | Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles |
| DE69429576T2 (de) * | 1993-09-30 | 2002-08-22 | Seikagaku Kogyo K.K., Tokio/Tokyo | Dermatansulfatezusammensetzung als antithromotisches mittel |
| US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US6001820A (en) * | 1995-03-31 | 1999-12-14 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US6106866A (en) * | 1995-07-31 | 2000-08-22 | Access Pharmaceuticals, Inc. | In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites |
| US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
| AU4938397A (en) * | 1996-12-24 | 1998-07-17 | Hyal Pharmaceutical Corporation | Methods of elevating amounts of hyaluronan in the human body |
| GB9711443D0 (en) * | 1997-06-03 | 1997-07-30 | Leo Pharm Prod Ltd | Chemical suppositions |
| FI974321A0 (fi) | 1997-11-25 | 1997-11-25 | Jenny Ja Antti Wihurin Rahasto | Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa |
| US6409987B1 (en) | 1999-04-07 | 2002-06-25 | Intimax Corporation | Targeted agents useful for diagnostic and therapeutic applications |
| US6518244B2 (en) | 2000-03-09 | 2003-02-11 | Intimax Corporation | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof |
| US20050164983A1 (en) * | 2003-12-19 | 2005-07-28 | Aventis Pharma S.A. | Carboxyl-reduced derivatives of dermatan sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them |
| EP1745145A4 (en) * | 2004-05-11 | 2008-03-26 | Heptest Lab Inc | COMPOSITIONS, KIT AND METHOD IN ONE STEP FOR MONITORING COMPOUNDS HAVING XA AND / OR ANTIFACTOR IIA ANTIFACTOR ACTIVITIES |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3124384C2 (de) * | 1981-06-22 | 1985-05-15 | Herbert Prof. Dr. 1000 Berlin Voß | Dermatanpolysulfat, Verfahren zu dessen Herstellung und dieses enthaltendes virushemmendes Mittel |
| IT1214609B (it) * | 1985-05-17 | 1990-01-18 | Opocrin Spa | Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. |
| FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
| IT1189085B (it) * | 1986-03-25 | 1988-01-28 | Mediolanum Farmaceutici Srl | Processo per la preparazione di dermatan solfato ad alta purezza e composizioni farmaceutiche che lo contengono |
| WO1991015217A1 (en) * | 1990-04-06 | 1991-10-17 | Washington University | Anticoagulant oligosaccharides |
-
1991
- 1991-08-28 IT ITMI912310A patent/IT1251183B/it active IP Right Grant
-
1992
- 1992-08-06 AU AU23962/92A patent/AU2396292A/en not_active Abandoned
- 1992-08-06 AT AT92916443T patent/ATE160149T1/de not_active IP Right Cessation
- 1992-08-06 DE DE69223153T patent/DE69223153T2/de not_active Expired - Fee Related
- 1992-08-06 CA CA002116437A patent/CA2116437A1/en not_active Abandoned
- 1992-08-06 US US08/199,229 patent/US5547944A/en not_active Expired - Fee Related
- 1992-08-06 DK DK92916443T patent/DK0600928T3/da active
- 1992-08-06 KR KR1019940700570A patent/KR100233338B1/ko not_active Expired - Fee Related
- 1992-08-06 WO PCT/EP1992/001790 patent/WO1993005074A1/en not_active Ceased
- 1992-08-06 ES ES92916443T patent/ES2110008T3/es not_active Expired - Lifetime
- 1992-08-06 EP EP92916443A patent/EP0600928B1/en not_active Expired - Lifetime
- 1992-08-06 JP JP50486293A patent/JP3279316B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE160149T1 (de) | 1997-11-15 |
| JP3279316B2 (ja) | 2002-04-30 |
| DK0600928T3 (da) | 1998-07-27 |
| IT1251183B (it) | 1995-05-04 |
| WO1993005074A1 (en) | 1993-03-18 |
| CA2116437A1 (en) | 1993-03-18 |
| AU2396292A (en) | 1993-04-05 |
| KR100233338B1 (ko) | 1999-12-01 |
| EP0600928B1 (en) | 1997-11-12 |
| ITMI912310A0 (it) | 1991-08-28 |
| ITMI912310A1 (it) | 1993-02-28 |
| EP0600928A1 (en) | 1994-06-15 |
| DE69223153D1 (de) | 1997-12-18 |
| JPH06510081A (ja) | 1994-11-10 |
| US5547944A (en) | 1996-08-20 |
| DE69223153T2 (de) | 1998-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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