ES2111019T3 - Derivados de espicamicina y utilizacion de los mismos. - Google Patents

Derivados de espicamicina y utilizacion de los mismos.

Info

Publication number
ES2111019T3
ES2111019T3 ES92111782T ES92111782T ES2111019T3 ES 2111019 T3 ES2111019 T3 ES 2111019T3 ES 92111782 T ES92111782 T ES 92111782T ES 92111782 T ES92111782 T ES 92111782T ES 2111019 T3 ES2111019 T3 ES 2111019T3
Authority
ES
Spain
Prior art keywords
integer
carbon atoms
given
espicamicina
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92111782T
Other languages
English (en)
Inventor
Noboru Otake
Hiroyuki Kawai
Tomiko Kawasaki
Atsuo Odagawa
Masaru Kamishohara
Teruyuki Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kirin Brewery Co Ltd
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Application granted granted Critical
Publication of ES2111019T3 publication Critical patent/ES2111019T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE DESCRIBE UN DERIVADO DE LA ESPICAMICINA NUEVO REPRESENTADO POR LA FORMULA (I) O UNA SAL SUYA: DONDE R REPRESENTA UN ALQUENIL CON UN NUMERO DADO DE ATOMOS DE CARBONO, UN HALOALQUIL CON UN NUMERO DADO DE ATOMOS DE CARBONO, CH3(CH2)NCH(OH)H3(CH2)N-1CH(OH)-CH2 UILCON CIERTO GRUPO Y UN NUMERO DADO DE ATOMOS DE CARBONO, (DONDE A ES 2 Y B ES UN ENTERO DE 10 A 15), CH3(CH2)CSO2O(CH2)D-, (DONDE C ES UN ENTERO DE 0 A 3 Y D ES UN ENTERO DE 10 A 15), (CH3)3SI(CH2)10-, (CH3)3SI-C TRIPLE ENLACE C-(CH2)8-, O (DONDE X REPRESENTA O O S), Y R1 Y R2 SON DIFERENTES ENTRE SI Y REPRESENTA H U OH, QUE EXHIBE UN EFECTO ANTI TUMOR EXCELENTE Y TIENE UN ELEVADO INDICE TERAPEUTICO. TAMBIEN SE DESCRIBE UN AGENTE ANTITUMOR QUE CONTIENE AL MENOS UNO DE LOS COMPUESTOS DESCRITOS ARRIBA EN UNA CANTIDAD EFECTIVA.
ES92111782T 1991-07-12 1992-07-10 Derivados de espicamicina y utilizacion de los mismos. Expired - Lifetime ES2111019T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP19890391 1991-07-12
JP32684591 1991-11-15
JP4110665A JP2783722B2 (ja) 1991-07-12 1992-04-03 スピカマイシン誘導体およびそれを含む抗腫瘍剤

Publications (1)

Publication Number Publication Date
ES2111019T3 true ES2111019T3 (es) 1998-03-01

Family

ID=27311786

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92111782T Expired - Lifetime ES2111019T3 (es) 1991-07-12 1992-07-10 Derivados de espicamicina y utilizacion de los mismos.

Country Status (16)

Country Link
US (2) US5461036A (es)
EP (1) EP0525479B1 (es)
JP (1) JP2783722B2 (es)
KR (1) KR100253050B1 (es)
AT (1) ATE159948T1 (es)
AU (1) AU657551B2 (es)
CA (1) CA2073567C (es)
DE (1) DE69222992T2 (es)
DK (1) DK0525479T3 (es)
ES (1) ES2111019T3 (es)
FI (1) FI105815B (es)
GR (1) GR3025293T3 (es)
HK (1) HK1001729A1 (es)
HU (1) HU221808B1 (es)
NO (1) NO178500C (es)
SG (1) SG52704A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7017208B2 (en) * 1995-08-04 2006-03-28 Hill-Rom Services, Inc. Hospital bed
US5905069A (en) * 1998-01-26 1999-05-18 The General Hospital Corporation Methods of decreasing or preventing pain using spicamycin or derivatives thereof
IL144461A0 (en) * 1999-01-22 2002-05-23 Kirin Brewery Quinoline and quinazoline derivatives and pharmaceutical compositions containing them
US7196071B2 (en) 2000-09-20 2007-03-27 The General Hospital Corporation Methods of decreasing or preventing pain using spicamycin derivatives
EP1565201B1 (en) * 2002-11-18 2018-10-31 Vicuron Pharmaceuticals, Inc. Methods of administering dalbavancin for treatment of bacterial infections
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
EP2295400A3 (en) * 2003-09-11 2012-10-24 Invista Technologies S.à.r.l. Process of hydrocyanation of unsaturated carboxylic acid derivatives
JP4608651B2 (ja) * 2004-06-24 2011-01-12 財団法人ヒューマンサイエンス振興財団 抗ガン作用を有する化合物、その製造方法及び抗ガン剤
US8119829B2 (en) * 2004-09-08 2012-02-21 Invista North America S.A.R.L. Process of hydrocyanation of unsaturated carboxylic acid derivatives
CN102202672A (zh) * 2008-10-10 2011-09-28 达拉生物科学公司 使用穗霉素衍生物治疗或预防疼痛的方法
EP2597082A1 (de) 2011-11-24 2013-05-29 Symrise AG Verbindungen zur Maskierung eines unangenehmen Geschmacks
KR20150038572A (ko) 2012-08-09 2015-04-08 다라 바이오싸이언시즈, 아이엔씨. 스피카마이신 유도체를 포함하는 조성물 및 이의 사용 방법
WO2015061481A1 (en) 2013-10-23 2015-04-30 Dara Biosciences, Inc. Methods of treating liquid tumors using compositions comprising spicamycin derivatives
CN110386874B (zh) * 2018-04-16 2022-10-04 湖北金鹤化工有限公司 一种12-酮基硬脂酸酯及其制备方法
TW202535940A (zh) * 2023-10-24 2025-09-16 美商思進公司 化學治療化合物及使用方法
CN117843703A (zh) * 2023-12-28 2024-04-09 中国科学院微生物研究所 一类庚糖杀菌素衍生物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155647A (en) 1963-07-24 1964-11-03 Olin Mathieson Septaciding and derivatives thereof
US3264195A (en) * 1963-07-24 1966-08-02 Squibb & Sons Inc Process for the preparation of septacidin and derivatives
US4086416A (en) * 1977-05-17 1978-04-25 Stanford Research Institute Septacidin analogs
JPS59161389A (ja) * 1983-03-07 1984-09-12 Eisai Co Ltd ７−カルボキシメトキシフエニルアセトアミドセフエム誘導体，その製造法およびそれからなる抗菌剤
JPS59161396A (ja) 1983-03-04 1984-09-12 Kirin Brewery Co Ltd 新規抗生物質スピカマイシン
US4975434A (en) * 1986-05-27 1990-12-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antiviral and anticancer cyclopentenyl cytosine
WO1990015811A1 (fr) 1989-06-16 1990-12-27 Kirin Beer Kabushiki Kaisha Spicamycine x et son utilisation

Also Published As

Publication number Publication date
NO922674L (no) 1993-01-13
DE69222992D1 (de) 1997-12-11
DK0525479T3 (da) 1998-04-20
ATE159948T1 (de) 1997-11-15
FI923170A0 (fi) 1992-07-09
NO922674D0 (no) 1992-07-08
SG52704A1 (en) 1998-09-28
CA2073567A1 (en) 1993-01-13
HUT61773A (en) 1993-03-01
NO178500C (no) 1996-04-10
HK1001729A1 (en) 1998-07-03
US5631238A (en) 1997-05-20
HU9202285D0 (en) 1992-10-28
FI105815B (fi) 2000-10-13
KR930002370A (ko) 1993-02-23
US5461036A (en) 1995-10-24
AU1960092A (en) 1993-01-14
NO178500B (no) 1996-01-02
AU657551B2 (en) 1995-03-16
JP2783722B2 (ja) 1998-08-06
GR3025293T3 (en) 1998-02-27
EP0525479B1 (en) 1997-11-05
DE69222992T2 (de) 1998-03-05
JPH05186494A (ja) 1993-07-27
EP0525479A1 (en) 1993-02-03
KR100253050B1 (ko) 2000-04-15
FI923170A7 (fi) 1993-01-13
CA2073567C (en) 1998-05-05
HU221808B1 (hu) 2003-01-28

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