GR3025293T3 - Spicamycin derivatives and the use thereof - Google Patents

Spicamycin derivatives and the use thereof

Info

Publication number: GR3025293T3
Authority: GR; Greece
Prior art keywords: chem; denotes; integer; carbon atoms; given number
Prior art date: 1991-07-12

Application number

GR970401503T

Other languages

English (en)

Inventor

Noboru Otake

Hiroyuki Kawai

Tomiko Kawasaki

Atsuo Odagawa

Masaru Kamishohara

Teruyuki Sakai

Original Assignee

Kirin Brewery

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-12

Filing date

1997-11-06

Publication date

1998-02-27

1997-11-06 Application filed by Kirin Brewery filed Critical Kirin Brewery

1998-02-27 Publication of GR3025293T3 publication Critical patent/GR3025293T3/el

Links

YBZRLMLGUBIIDN-NZSGCTDASA-N spicamycin Chemical class O1[C@@H](C(O)CO)[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC(C)C)[C@@H](O)[C@@H](O)[C@H]1NC1=NC=NC2=C1N=CN2 YBZRLMLGUBIIDN-NZSGCTDASA-N 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 3
DCERHCFNWRGHLK-UHFFFAOYSA-N C[Si](C)C Chemical compound C[Si](C)C DCERHCFNWRGHLK-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
231100001274 therapeutic index Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

GR970401503T 1991-07-12 1997-11-06 Spicamycin derivatives and the use thereof GR3025293T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP19890391		1991-07-12
JP32684591		1991-11-15
JP4110665A JP2783722B2 (ja)	1991-07-12	1992-04-03	スピカマイシン誘導体およびそれを含む抗腫瘍剤

Publications (1)

Publication Number	Publication Date
GR3025293T3 true GR3025293T3 (en)	1998-02-27

Family

ID=27311786

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR970401503T GR3025293T3 (en)	1991-07-12	1997-11-06	Spicamycin derivatives and the use thereof

Country Status (16)

Country	Link
US (2)	US5461036A (el)
EP (1)	EP0525479B1 (el)
JP (1)	JP2783722B2 (el)
KR (1)	KR100253050B1 (el)
AT (1)	ATE159948T1 (el)
AU (1)	AU657551B2 (el)
CA (1)	CA2073567C (el)
DE (1)	DE69222992T2 (el)
DK (1)	DK0525479T3 (el)
ES (1)	ES2111019T3 (el)
FI (1)	FI105815B (el)
GR (1)	GR3025293T3 (el)
HK (1)	HK1001729A1 (el)
HU (1)	HU221808B1 (el)
NO (1)	NO178500C (el)
SG (1)	SG52704A1 (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7017208B2 (en) *	1995-08-04	2006-03-28	Hill-Rom Services, Inc.	Hospital bed
US5905069A (en) *	1998-01-26	1999-05-18	The General Hospital Corporation	Methods of decreasing or preventing pain using spicamycin or derivatives thereof
ATE356117T1 (de) *	1999-01-22	2007-03-15	Kirin Brewery	Derivate des n-((chinolinyl)oxy)-phenyl)- harnstoffs und des n-((chinazolinyl)oxy)-phenyl)- harnstoffs mit antitumor aktivität
AU2001291133A1 (en) *	2000-09-20	2002-04-02	The General Hospital Corporation	Methods of decreasing or preventing pain using spicamycin derivatives
US20060074014A1 (en) *	2002-11-18	2006-04-06	Vicuron Pharmaceuticals Inc.	Dalbavancin compositions for treatment of bacterial infections
MXPA05005338A (es) *	2002-11-18	2005-12-14	Vicuron Pharm Inc	Metodos para administrar dalbavancin para el tratamiento de infecciones bacterianas.
EP2154127A3 (en) *	2003-09-11	2010-10-13	Invista Technologies S.à.r.l.	Conversion of hydrocyanated unsaturated carboxylic acid derivatives into amines
JP4608651B2 (ja) *	2004-06-24	2011-01-12	財団法人ヒューマンサイエンス振興財団	抗ガン作用を有する化合物、その製造方法及び抗ガン剤
US8119829B2 (en) *	2004-09-08	2012-02-21	Invista North America S.A.R.L.	Process of hydrocyanation of unsaturated carboxylic acid derivatives
JP5753784B2 (ja) *	2008-10-10	2015-07-22	ダラ・バイオサイエンシズ，インコーポレイテッド	スピカマイシン誘導体を用いて疼痛を治療又は予防する方法
EP2597082A1 (de)	2011-11-24	2013-05-29	Symrise AG	Verbindungen zur Maskierung eines unangenehmen Geschmacks
JP2015524482A (ja) *	2012-08-09	2015-08-24	ダラ・バイオサイエンシズ，インコーポレイテッド	スピカマイシン誘導体を含む組成物およびその使用方法
WO2015061481A1 (en)	2013-10-23	2015-04-30	Dara Biosciences, Inc.	Methods of treating liquid tumors using compositions comprising spicamycin derivatives
CN110386874B (zh) *	2018-04-16	2022-10-04	湖北金鹤化工有限公司	一种12-酮基硬脂酸酯及其制备方法
AR134171A1 (es) *	2023-10-24	2025-12-10	Seagen Inc	Compuestos quimioterapéuticos y métodos de uso

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3264195A (en) *	1963-07-24	1966-08-02	Squibb & Sons Inc	Process for the preparation of septacidin and derivatives
US3155647A (en)	1963-07-24	1964-11-03	Olin Mathieson	Septaciding and derivatives thereof
US4086416A (en) *	1977-05-17	1978-04-25	Stanford Research Institute	Septacidin analogs
JPS59161389A (ja) *	1983-03-07	1984-09-12	Eisai Co Ltd	７−カルボキシメトキシフエニルアセトアミドセフエム誘導体，その製造法およびそれからなる抗菌剤
JPS59161396A (ja) *	1983-03-04	1984-09-12	Kirin Brewery Co Ltd	新規抗生物質スピカマイシン
US4975434A (en) *	1986-05-27	1990-12-04	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Antiviral and anticancer cyclopentenyl cytosine
WO1990015811A1 (fr)	1989-06-16	1990-12-27	Kirin Beer Kabushiki Kaisha	Spicamycine x et son utilisation

1992
- 1992-04-03 JP JP4110665A patent/JP2783722B2/ja not_active Expired - Lifetime
- 1992-07-08 NO NO922674A patent/NO178500C/no not_active IP Right Cessation
- 1992-07-08 US US07/910,640 patent/US5461036A/en not_active Expired - Lifetime
- 1992-07-09 FI FI923170A patent/FI105815B/fi active
- 1992-07-10 CA CA002073567A patent/CA2073567C/en not_active Expired - Lifetime
- 1992-07-10 SG SG1996008096A patent/SG52704A1/en unknown
- 1992-07-10 AU AU19600/92A patent/AU657551B2/en not_active Ceased
- 1992-07-10 HU HU9202285A patent/HU221808B1/hu not_active IP Right Cessation
- 1992-07-10 ES ES92111782T patent/ES2111019T3/es not_active Expired - Lifetime
- 1992-07-10 AT AT92111782T patent/ATE159948T1/de active
- 1992-07-10 DK DK92111782.6T patent/DK0525479T3/da active
- 1992-07-10 DE DE69222992T patent/DE69222992T2/de not_active Expired - Lifetime
- 1992-07-10 EP EP92111782A patent/EP0525479B1/en not_active Expired - Lifetime
- 1992-07-11 KR KR1019920012373A patent/KR100253050B1/ko not_active Expired - Fee Related
1995
- 1995-04-26 US US08/429,303 patent/US5631238A/en not_active Expired - Lifetime
1997
- 1997-11-06 GR GR970401503T patent/GR3025293T3/el unknown
1998
- 1998-01-21 HK HK98100557A patent/HK1001729A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR100253050B1 (ko)	2000-04-15
CA2073567A1 (en)	1993-01-13
DE69222992D1 (de)	1997-12-11
EP0525479A1 (en)	1993-02-03
ES2111019T3 (es)	1998-03-01
HU221808B1 (hu)	2003-01-28
FI923170A0 (fi)	1992-07-09
FI923170A7 (fi)	1993-01-13
AU657551B2 (en)	1995-03-16
US5631238A (en)	1997-05-20
NO178500C (no)	1996-04-10
AU1960092A (en)	1993-01-14
HUT61773A (en)	1993-03-01
SG52704A1 (en)	1998-09-28
JP2783722B2 (ja)	1998-08-06
CA2073567C (en)	1998-05-05
NO178500B (no)	1996-01-02
HU9202285D0 (en)	1992-10-28
FI105815B (fi)	2000-10-13
JPH05186494A (ja)	1993-07-27
NO922674D0 (no)	1992-07-08
EP0525479B1 (en)	1997-11-05
NO922674L (no)	1993-01-13
DE69222992T2 (de)	1998-03-05
ATE159948T1 (de)	1997-11-15
HK1001729A1 (en)	1998-07-03
DK0525479T3 (da)	1998-04-20
KR930002370A (ko)	1993-02-23
US5461036A (en)	1995-10-24

Publication	Publication Date	Title
EP0694558A4 (en)	1996-08-21	SPHINGOGLYCOLIPID AND USE THEREOF
SG52704A1 (en)	1998-09-28	Specamycin derivatives and the use thereof
TW261533B (el)	1995-11-01
EP0416117A4 (en)	1992-02-19	Liquid crystal composition
HU9400062D0 (en)	1994-05-30	Process for the preparation of baccatin iii and 10-deacetyl baccatin iii derivatives
TW222009B (el)	1994-04-01
DE3875346D1 (de)	1992-11-19	Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten.
TW337985B (en)	1998-08-11	"N-(B-branched alkyl)-1, 2-benzisothiolin, 3ones, their preparation and their use as industrial biocides"
GR3034023T3 (en)	2000-11-30	Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
DK0531091T3 (da)	1995-09-11	Biologisk nedbrydelig copolyester af 4-hydroxyprolin og farmaceutisk præparat indeholdende samme
ZA907639B (en)	1991-07-31	Benzanilides
IE901314L (en)	1990-10-15	2- substituted-n,n'-di(trimethoxybenzoyl)piperazines
MY106839A (en)	1995-08-30	Carboxylate compounds, liquid crystal compositions containing said compounds and liquid crystal elements.
DK0502304T3 (da)	1993-11-29	Middel til permanentbølgning af menneskehår indeholdende alkylpolyglycosider
DK606286D0 (da)	1986-12-16	Anthracyclin-derivater og laegemidler indeholdende disse forbindelser
ES2023760A6 (es)	1992-02-01	Procedimiento para la preparacion de derivados benzotiazinicos.
EP0418922A3 (en)	1991-07-03	Mesomorphic compound, liquid crystal composition containing same and liquid crystal device using same
ES2068685T3 (es)	1995-04-16	Procedimiento de preparacion de nuevos derivados de 1,5-diin-cicloalquenos.
ATE24887T1 (de)	1987-01-15	Cycloaliphatische alkohole.
TH14773A (th)	1994-09-30	อนุพันธ์ของอีริโธรมัยซิน