ES2111025T3 - Piridinilamino-1h-indoles, 1h-indazoles, 2h-indazoles, benzo(b)tiofenos y 1,2-benzoisotiazoles sustituidos, un procedimiento para su preparacion y su utilizacion como medicamentos. - Google Patents

Piridinilamino-1h-indoles, 1h-indazoles, 2h-indazoles, benzo(b)tiofenos y 1,2-benzoisotiazoles sustituidos, un procedimiento para su preparacion y su utilizacion como medicamentos.

Info

Publication number
ES2111025T3
ES2111025T3 ES92116110T ES92116110T ES2111025T3 ES 2111025 T3 ES2111025 T3 ES 2111025T3 ES 92116110 T ES92116110 T ES 92116110T ES 92116110 T ES92116110 T ES 92116110T ES 2111025 T3 ES2111025 T3 ES 2111025T3
Authority
ES
Spain
Prior art keywords
indazoles
hydrogen
useful
lower alkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92116110T
Other languages
English (en)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Lawrence Leo Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2111025T3 publication Critical patent/ES2111025T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

ESTA INVENCION SE REFIERE A PIRIDINILAMINO-1H-INDOLES, 1HINDAZOLES, 2H-INDAZOLES, BENZO[B] LES SUSTITUIDOS DE LA FORMULA EN DONDE Q ES S, N O NR2; Y ES CH, N O NR2; R1 ES HIDROGENO, ALKILO INFERIOR, ALKINILO INFERIOR, ALQUENILO INFERIOR, ARILALKILO INFERIOR, ALCOXICARBONILAMINO INFERIOR ALKILCARBONILO INFERIOR, ARIL INFERIOR ALCOXICARBONIL-AMINO INFERIOR CARBONILO, AMINO INFERIOR ALKILCARBONILO, ALCOXICARBONILO INFERIOR O ACILO; R2 ES HIDROGENO O ALKILO INFERIOR; R3 ES HIDROGENO O ALKILO INFERIOR; X ES HIDROGENO, ALKILO INFERIOR, HALOGENO; Y N ES 0 O 1; O UNA SAL DE ADICION FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. LOS COMPUESTOS DE ESTA INVENCION SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS DE LA MEMORIA CARACTERIZADOS POR UN DEFICIT COLINERGICO TAL COMO EL TIPO ASOCIADO A LA ENFERMEDAD DE ALZHEIMER Y OTROS TRASTORNOS DE LA MEMORIA. LOS COMPUESTOS DE ESTA INVENCION TAMBIEN SON UTILES COMO MODULADORES DE LA FUNCION NEUROTRANSMISORA TALES COMO LA NORADRENEGICA O SEROTONERGICA Y COMO TALES SON UTILES PARA EL TRATAMIENTO DE LA DEPRESION Y DE TRASTORNOS DE LA PERSONALIDAD TALES COMO LOS TRASTORNOS COMPULSIVOS OBSESIVOS. ADICIONALMENTE, LOS COMPUESTOS DE ESTA INVENCION SON UTILES COMO AGENTES ANTIINFLAMATORIOS TOPICOS PARA EL TRATAMIENTO DE DISTINTAS DERMATOSIS.
ES92116110T 1991-09-23 1992-09-21 Piridinilamino-1h-indoles, 1h-indazoles, 2h-indazoles, benzo(b)tiofenos y 1,2-benzoisotiazoles sustituidos, un procedimiento para su preparacion y su utilizacion como medicamentos. Expired - Lifetime ES2111025T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/764,031 US5185350A (en) 1991-09-23 1991-09-23 Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles

Publications (1)

Publication Number Publication Date
ES2111025T3 true ES2111025T3 (es) 1998-03-01

Family

ID=25069502

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92116110T Expired - Lifetime ES2111025T3 (es) 1991-09-23 1992-09-21 Piridinilamino-1h-indoles, 1h-indazoles, 2h-indazoles, benzo(b)tiofenos y 1,2-benzoisotiazoles sustituidos, un procedimiento para su preparacion y su utilizacion como medicamentos.

Country Status (18)

Country Link
US (2) US5185350A (es)
EP (1) EP0534343B1 (es)
JP (1) JP2961023B2 (es)
KR (1) KR930006006A (es)
AT (1) ATE160346T1 (es)
AU (1) AU653263B2 (es)
CA (1) CA2078814C (es)
CZ (1) CZ290692A3 (es)
DE (1) DE69223205T2 (es)
DK (1) DK0534343T3 (es)
ES (1) ES2111025T3 (es)
FI (1) FI924230A7 (es)
GR (1) GR3025774T3 (es)
HU (1) HU9203023D0 (es)
IL (1) IL103232A0 (es)
MX (1) MX9205374A (es)
NO (1) NO923686L (es)
TW (1) TW207539B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992005170A1 (en) * 1990-09-13 1992-04-02 Beecham Group Plc Indole ureas as 5 ht receptor antagonist
US5356910A (en) 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
JPH09507071A (ja) * 1993-12-21 1997-07-15 イーライ・リリー・アンド・カンパニー アミロイド原性ペプチドに関連した状態を治療又は予防する方法
DE19626373A1 (de) * 1996-07-02 1998-01-08 Boehringer Ingelheim Kg Neuartige Verwendung von Wirkstoffen, welche die Funktion von nichtneuronalem Acetylcholin beeinflussen
TW200302722A (en) * 2002-02-13 2003-08-16 Astrazeneca Ab Therapeutic agents
US20050222123A1 (en) 2004-01-27 2005-10-06 North Shore-Long Island Jewish Research Institute Cholinesterase inhibitors for treating inflammation
JP4857128B2 (ja) 2004-02-20 2012-01-18 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 新規な化合物
JP4787471B2 (ja) * 2004-05-21 2011-10-05 株式会社ポッカコーポレーション 脳機能亢進剤
BRPI0511722A (pt) 2004-06-01 2008-01-08 Hoffmann La Roche 3-amino-1-arilpropilindóis como inibidores da recaptação de monoamina
AU2006319231A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
JP2009517432A (ja) 2005-11-30 2009-04-30 エフ．ホフマン−ラ ロシュ アーゲー ３−アミノ−２−アリールプロピルアザインドールおよびその使用
EP2351737A1 (en) * 2005-11-30 2011-08-03 F. Hoffmann-La Roche AG 3-Amino-1-arylpropyl indoles and aza-substituted indoles
KR102534969B1 (ko) * 2021-08-20 2023-05-26 김수영 포켓 인슐레이터 및 이를 포함하는 단열체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0287982B1 (en) * 1987-04-24 1994-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments
US4970219A (en) * 1989-06-28 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which have useful utility in treating skin disorders
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5177088A (en) * 1991-04-17 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 3-(pyridinylamino)-indoles

Also Published As

Publication number Publication date
HUT64055A (en) 1993-11-29
KR930006006A (ko) 1993-04-20
AU653263B2 (en) 1994-09-22
CZ290692A3 (en) 1993-04-14
FI924230A0 (fi) 1992-09-21
US5185350A (en) 1993-02-09
NO923686D0 (no) 1992-09-22
GR3025774T3 (en) 1998-03-31
US5328918A (en) 1994-07-12
IL103232A0 (en) 1993-02-21
DE69223205T2 (de) 1998-05-14
AU2529792A (en) 1993-03-25
EP0534343A1 (en) 1993-03-31
ATE160346T1 (de) 1997-12-15
EP0534343B1 (en) 1997-11-19
JP2961023B2 (ja) 1999-10-12
NO923686L (no) 1993-03-24
DE69223205D1 (de) 1998-01-02
CA2078814A1 (en) 1993-03-24
DK0534343T3 (da) 1998-07-27
TW207539B (es) 1993-06-11
FI924230L (fi) 1993-03-24
HU9203023D0 (en) 1993-11-29
MX9205374A (es) 1993-03-01
FI924230A7 (fi) 1993-03-24
CA2078814C (en) 2003-09-09
JPH061787A (ja) 1994-01-11

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