ES2132761T3 - Derivados del acido piperidin acetico utiles como antagonistas del fibrinogeno. - Google Patents

Derivados del acido piperidin acetico utiles como antagonistas del fibrinogeno.

Info

Publication number
ES2132761T3
ES2132761T3 ES95942704T ES95942704T ES2132761T3 ES 2132761 T3 ES2132761 T3 ES 2132761T3 ES 95942704 T ES95942704 T ES 95942704T ES 95942704 T ES95942704 T ES 95942704T ES 2132761 T3 ES2132761 T3 ES 2132761T3
Authority
ES
Spain
Prior art keywords
derivatives
acetico
fibrinogen
antagonists
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95942704T
Other languages
English (en)
Inventor
David George Allen
Colin David Eldred
William Leonard Mitchell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9426231.8A external-priority patent/GB9426231D0/en
Priority claimed from GBGB9503133.2A external-priority patent/GB9503133D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2132761T3 publication Critical patent/ES2132761T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION DESCRIBE LOS COMPUESTOS DE LA FORMULA (I) Y DERIVADOS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, DONDE: X REPRESENTA CH{SUB,2} - CH{SUB,2} O CH = CH, E Y REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO FENILMETILO, DONDE EL GRUPO FENILO ESTA SUSTITUIDO OPCIONALMENTE POR UNO O MAS ATOMOS DE HALOGENO. LOS COMPUESTOS DE LA FORMULA (I) INHIBEN LA AGREGACION PLAQUETARIA.
ES95942704T 1994-12-23 1995-12-21 Derivados del acido piperidin acetico utiles como antagonistas del fibrinogeno. Expired - Lifetime ES2132761T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9426231.8A GB9426231D0 (en) 1994-12-23 1994-12-23 Chemical compounds
GBGB9503133.2A GB9503133D0 (en) 1995-02-17 1995-02-17 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2132761T3 true ES2132761T3 (es) 1999-08-16

Family

ID=26306268

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95942704T Expired - Lifetime ES2132761T3 (es) 1994-12-23 1995-12-21 Derivados del acido piperidin acetico utiles como antagonistas del fibrinogeno.

Country Status (21)

Country Link
US (1) US5861414A (es)
EP (1) EP0799223B1 (es)
JP (1) JPH10511375A (es)
CN (1) CN1175254A (es)
AP (1) AP9701010A0 (es)
AR (1) AR002260A1 (es)
AT (1) ATE181071T1 (es)
AU (1) AU704496B2 (es)
CO (1) CO4700291A1 (es)
DE (1) DE69510228T2 (es)
DK (1) DK0799223T3 (es)
ES (1) ES2132761T3 (es)
FI (1) FI972684L (es)
GR (1) GR3031027T3 (es)
IL (1) IL116480A0 (es)
NO (1) NO972887L (es)
NZ (1) NZ298400A (es)
PE (1) PE63696A1 (es)
SI (1) SI0799223T1 (es)
WO (1) WO1996020192A1 (es)
ZA (1) ZA951822B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
GB9613096D0 (en) * 1996-06-21 1996-08-28 Glaxo Group Ltd Medicaments
IL129416A0 (en) 1996-10-14 2000-02-17 Bayer Ag New heterocyclylmethyl-substituted pyrazol derivatives
WO1998043962A1 (en) * 1997-03-28 1998-10-08 Du Pont Pharmaceuticals Company Heterocyclic integrin inhibitor prodrugs
US7141581B2 (en) * 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
YU54202A (sh) * 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
MXPA03005432A (es) * 2000-12-22 2003-09-10 Wyeth Corp Compuestos de heterociclilindazol y -azaindazol como ligandos de 5-hidroxitriptamina-6.
US7008953B2 (en) 2003-07-30 2006-03-07 Agouron Pharmaceuticals, Inc. 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
GB0400895D0 (en) * 2004-01-15 2004-02-18 Smithkline Beecham Corp Chemical compounds
AR050253A1 (es) * 2004-06-24 2006-10-11 Smithkline Beecham Corp Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
JP2025530213A (ja) 2022-09-09 2025-09-11 ミリックス ファーマ リミテッド Ｎｍｔ阻害剤を含む抗体薬物コンジュゲート及びその使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681382A (en) * 1969-02-07 1972-08-01 Ciba Geigy Corp 3-aminoindazoles
JPH07501063A (ja) * 1991-11-14 1995-02-02 グラクソ、グループ、リミテッド フィブリノーゲン依存性血小板凝集阻害剤としてのピペリジン酢酸誘導体
US5219867A (en) * 1991-12-16 1993-06-15 Research Corporation Technologies, Inc. Platelet aggregation inhibitory agents
JPH05255308A (ja) * 1992-03-11 1993-10-05 Ajinomoto Co Inc ピペリジン誘導体
JP3194777B2 (ja) * 1992-03-13 2001-08-06 学校法人東京薬科大学 立体選択的ｄ−リボフラノシル化法
JPH06234633A (ja) * 1993-02-10 1994-08-23 Ajinomoto Co Inc アミン誘導体およびこれを含有する抗血小板剤

Also Published As

Publication number Publication date
CN1175254A (zh) 1998-03-04
AR002260A1 (es) 1998-03-11
FI972684A7 (fi) 1997-06-19
DE69510228T2 (de) 1999-11-04
FI972684A0 (fi) 1997-06-19
NO972887D0 (no) 1997-06-20
GR3031027T3 (en) 1999-12-31
AP9701010A0 (en) 1997-07-31
FI972684L (fi) 1997-06-19
ATE181071T1 (de) 1999-06-15
EP0799223A1 (en) 1997-10-08
NZ298400A (en) 1999-10-28
CO4700291A1 (es) 1998-12-29
JPH10511375A (ja) 1998-11-04
IL116480A0 (en) 1996-03-31
EP0799223B1 (en) 1999-06-09
SI0799223T1 (en) 1999-10-31
DK0799223T3 (da) 1999-12-27
DE69510228D1 (de) 1999-07-15
WO1996020192A1 (en) 1996-07-04
NO972887L (no) 1997-08-20
ZA951822B (en) 1996-09-26
US5861414A (en) 1999-01-19
AU704496B2 (en) 1999-04-22
AU4387896A (en) 1996-07-19
PE63696A1 (es) 1997-01-11

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