ES2111124T3 - Procedimiento para separar enantiomeros de ester benzoilico de 1,2-isopropilidenglicerol. - Google Patents

Procedimiento para separar enantiomeros de ester benzoilico de 1,2-isopropilidenglicerol.

Info

Publication number
ES2111124T3
ES2111124T3 ES93200395T ES93200395T ES2111124T3 ES 2111124 T3 ES2111124 T3 ES 2111124T3 ES 93200395 T ES93200395 T ES 93200395T ES 93200395 T ES93200395 T ES 93200395T ES 2111124 T3 ES2111124 T3 ES 2111124T3
Authority
ES
Spain
Prior art keywords
ester
benzoilic
isopropylidenglycerol
procedure
separating enantiomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93200395T
Other languages
English (en)
Inventor
Daniele Bianchi
Aldo Bosetti
Pietro Cesti
Paolo Golini
Carlo Pina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Original Assignee
Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST) filed Critical Ministero dell Universita e della Ricerca Scientifica e Tecnologica (MURST)
Application granted granted Critical
Publication of ES2111124T3 publication Critical patent/ES2111124T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA SEPARAR LOS ISOMEROS OPTICOS DEL 1,2-ISOPROPILIDENOGLICEROL, DE LA FORMULA I, EL PROCESO COMPRENDE LA HIDROLISIS ENZIMATICA PARCIAL Y ESTEROSELECTIVA DE UN ESTER DE BENZOIL DE 1,2-ISOPROPILIDENOGLICEROL (II) CATALIZADA POR UNA LIPASA LIBRE O INMOVILIZADA, LA HIDROLISIS SE CONDUCE EN LA PRESENCIA DE UN COSOLVENTE Y ES SEGUIDA POR UNA CRISTALIZACION QUE HACE POSIBLE QUE SE OBTENGAN CRITALES DE (II) EN FORMA DE RACIMO Y LICOR MADRE QUE CONTENGA (II) EN FORMA DE ENANTIOMERO PURO. EL COMPUESTO (I) ES AMPLIAMENTE USADO DE FORMA INDUSTRIAL COMO PRODUCTO INTERMEDIO EN LA SINTESIS DE DROGAS QUIRALES TALES COMO LA R-(-)-CARNITINA, (S)-BLOQUEADORES BETA, AGENTES ANTIVIRALES (S), DROGAS ANALGESICAS, ETC.
ES93200395T 1992-02-17 1993-02-12 Procedimiento para separar enantiomeros de ester benzoilico de 1,2-isopropilidenglicerol. Expired - Lifetime ES2111124T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920331A IT1254463B (it) 1992-02-17 1992-02-17 Processo per la preparazione di (r) e (s)-1,2-isopropilidenglicerolo

Publications (1)

Publication Number Publication Date
ES2111124T3 true ES2111124T3 (es) 1998-03-01

Family

ID=11361994

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93200395T Expired - Lifetime ES2111124T3 (es) 1992-02-17 1993-02-12 Procedimiento para separar enantiomeros de ester benzoilico de 1,2-isopropilidenglicerol.

Country Status (9)

Country Link
US (1) US5332674A (es)
EP (1) EP0556909B1 (es)
JP (1) JP3195108B2 (es)
AT (1) ATE161290T1 (es)
CA (1) CA2089626C (es)
DE (1) DE69315720T2 (es)
DK (1) DK0556909T3 (es)
ES (1) ES2111124T3 (es)
IT (1) IT1254463B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6300176B1 (en) * 1994-07-22 2001-10-09 Semiconductor Energy Laboratory Co., Ltd. Laser processing method
ITMI20022273A1 (it) * 2002-10-25 2004-04-26 Prime Europ Therapeuticals Sintesi enzimatica di (s)-1, 2-0-1, 2-0-isopropilidenglicerolo.
DE10336270B3 (de) * 2003-08-07 2005-04-14 Consortium für elektrochemische Industrie GmbH Verfahren zur enantioselektiven Herstellung von sekundären Alkoholen durch lipasenkatalysierte Solvolyse der korrespondierenden Acetessigester

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957868A (en) * 1984-12-24 1990-09-18 Chiyoda Chemical Engineering & Constructions Co., Ltd. Cylindrical hollow carriers for microorganisms made of nonwoven fabric
IL82416A0 (en) * 1986-05-08 1987-11-30 Gist Brocades Nv Process for the preparation of r-2,2-r1,r2-1,3-dioxolane-4-methanol
EP0401704B1 (en) * 1989-06-03 1995-02-15 Mitsubishi Rayon Co., Ltd Process for the preparation of organic esters

Also Published As

Publication number Publication date
DE69315720D1 (de) 1998-01-29
IT1254463B (it) 1995-09-25
US5332674A (en) 1994-07-26
DK0556909T3 (da) 1998-08-24
ITMI920331A1 (it) 1993-08-17
JP3195108B2 (ja) 2001-08-06
CA2089626C (en) 2001-01-16
ATE161290T1 (de) 1998-01-15
CA2089626A1 (en) 1993-08-18
JPH067195A (ja) 1994-01-18
DE69315720T2 (de) 1998-07-23
EP0556909A1 (en) 1993-08-25
EP0556909B1 (en) 1997-12-17
ITMI920331A0 (it) 1992-02-17

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