ES2111304T3 - Composicion de administracion por via nasal de un medicamento que contiene nicotina. - Google Patents

Composicion de administracion por via nasal de un medicamento que contiene nicotina.

Info

Publication number
ES2111304T3
ES2111304T3 ES94915637T ES94915637T ES2111304T3 ES 2111304 T3 ES2111304 T3 ES 2111304T3 ES 94915637 T ES94915637 T ES 94915637T ES 94915637 T ES94915637 T ES 94915637T ES 2111304 T3 ES2111304 T3 ES 2111304T3
Authority
ES
Spain
Prior art keywords
nicotine
ion
compound
nasal administration
absorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94915637T
Other languages
English (en)
Inventor
Lisbeth Illum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Services Ltd
Original Assignee
Danbiosyst UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danbiosyst UK Ltd filed Critical Danbiosyst UK Ltd
Application granted granted Critical
Publication of ES2111304T3 publication Critical patent/ES2111304T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Optical Filters (AREA)
  • Diffracting Gratings Or Hologram Optical Elements (AREA)
  • Lasers (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN COMPUESTO PARA MEDICAMENTO DE ADMINISTRACION NASAL CON CONTENIDO EN NICOTINA O UNA SAL FARMACEUTICAMENTE ACEPTABLE, O UN DERIVADO DE LA MISMA EN EL QUE EL COMPUESTO SE ADAPTA AL SUMINISTRO DE UN PULSO DE NICOTINA PARA ABSORCION RAPIDA Y DE UNA LIBERACION DE NICOTINA CONTROLADA PARA SU POSTERIOR ABSORCION SOSTENIDA. LA FASE DE SUMINISTRO CONTROLADO PUEDE LOGRARSE PROPORCIONANDO UN MATERIAL PERMUTADOR DE IONES QUE FORMARA UN COMPLEJO CON LA NICOTINA. EL MATERIAL PERMUTADOR DE IONES PUEDE SER UN MATERIAL POLIMERICO COMO LOS POLISACARIDOS, O PUEDE PRESENTARSE EN FORMA DE MICROSFERAS BIOADHESIVAS PERMUTADORAS DE IONES . LA LIBERACION DE PULSOS PUEDE LOGRARSE SOBRECARGADO EL MATERIAL PERMUTADOR DE IONES CON NICOTINA, DE FORMA QUE EL COMPUESTO TENGA UN EXCESO DE NICOTINA PARA SU INMEDIATA LIBERACION Y ABSORCION. DE FORMA ALTERNATIVA, UNA PARTE DE LA NICOTINA PUEDE ESTAR ASOCIADA CON UN MATERIAL NO PERMUTADOR DE IONES QUE LIBERARA LA NICOTINA INMEDIATAMENTE AL ENTRAR EN CONTACTO CON LA MUCOSA NASAL, COMO POR EJEMPLO LAS MICROSFERAS BIOADHESIVAS NO PERMUTADORAS DE IONES.
ES94915637T 1993-05-20 1994-05-20 Composicion de administracion por via nasal de un medicamento que contiene nicotina. Expired - Lifetime ES2111304T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939310412A GB9310412D0 (en) 1993-05-20 1993-05-20 Nasal nicotine system

Publications (1)

Publication Number Publication Date
ES2111304T3 true ES2111304T3 (es) 1998-03-01

Family

ID=10735826

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94915637T Expired - Lifetime ES2111304T3 (es) 1993-05-20 1994-05-20 Composicion de administracion por via nasal de un medicamento que contiene nicotina.

Country Status (14)

Country Link
US (1) US5935604A (es)
EP (1) EP0697858B1 (es)
JP (1) JPH08510467A (es)
AT (1) ATE159425T1 (es)
AU (1) AU685458B2 (es)
CA (1) CA2163089A1 (es)
DE (1) DE69406440T2 (es)
DK (1) DK0697858T3 (es)
ES (1) ES2111304T3 (es)
FI (1) FI955583A7 (es)
GB (2) GB9310412D0 (es)
GR (1) GR3025890T3 (es)
NO (1) NO306847B1 (es)
WO (1) WO1994027576A1 (es)

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Also Published As

Publication number Publication date
DK0697858T3 (da) 1998-05-04
GB2292316A (en) 1996-02-21
AU6727294A (en) 1994-12-20
CA2163089A1 (en) 1994-12-08
GB9523372D0 (en) 1996-01-17
JPH08510467A (ja) 1996-11-05
EP0697858B1 (en) 1997-10-22
GR3025890T3 (en) 1998-04-30
DE69406440T2 (de) 1998-04-02
WO1994027576A1 (en) 1994-12-08
FI955583L (fi) 1996-01-19
NO306847B1 (no) 2000-01-03
FI955583A0 (fi) 1995-11-20
NO954582D0 (no) 1995-11-14
DE69406440D1 (de) 1997-11-27
US5935604A (en) 1999-08-10
FI955583A7 (fi) 1996-01-19
AU685458B2 (en) 1998-01-22
NO954582L (no) 1995-11-14
ATE159425T1 (de) 1997-11-15
EP0697858A1 (en) 1996-02-28
GB2292316B (en) 1997-03-26
GB9310412D0 (en) 1993-07-07

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