ES2111775T3 - Pancreas biohibrido artificial implantable y rellenable. - Google Patents

Pancreas biohibrido artificial implantable y rellenable.

Info

Publication number
ES2111775T3
ES2111775T3 ES93922765T ES93922765T ES2111775T3 ES 2111775 T3 ES2111775 T3 ES 2111775T3 ES 93922765 T ES93922765 T ES 93922765T ES 93922765 T ES93922765 T ES 93922765T ES 2111775 T3 ES2111775 T3 ES 2111775T3
Authority
ES
Spain
Prior art keywords
bag
pancreas
biohibrido
fillable
artificial pancreas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93922765T
Other languages
English (en)
Inventor
You Han Bae
Sung Wan Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah
Original Assignee
University of Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah filed Critical University of Utah
Application granted granted Critical
Publication of ES2111775T3 publication Critical patent/ES2111775T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

SE PRESENTA UN SISTEMA DE PANCREAS ARTIFICIAL QUE MINIMIZA EL VOLUMEN DEL PANCREAS ARTIFICIAL AL NO ENCAPSULAR CADA ISLOTE (15) EN DONDE LOS ISLOTES (15) SE SEPARAN Y MANTIENEN DENTRO DE UNA MATRIZ POLIMERICA (14) SOLUBLE EN UNA SOLUCION ACUOSA POR DEBAJO DE LA TEMPERATURA DEL CUERPO PERO INSOLUBLE EN UNA SOLUCION ACUOSA A O POR ENCIMA DE LA TEMPERATURA DEL CUERPO. LA MEZCLA DE POLIMERO E ISLOTE SE GUARDA EN UNA BOLSA DE MEMBRANA BIOCOMPATIBLE (10) QUE TIENE UNOS ELEMENTOS DE ACCESO TAL COMO UNOS ORIFICIOS DE ENTRADA Y SALIDA (31, 32). LA SOLUBILIDAD HACE QUE SE PUEDA SUSTITUIR EL CONTENIDO DE LA BOLSA (10) A BASE DE SOLUBILIZAR LA MATRIZ (14) CON SOLO BAJAR LA TEMPERATURA A POR DEBAJO DE LA LCST. LA BOLSA (10) ES PERMEABLE A LA INSULINA Y A OTRAS SUSTANCIAS CON UN PESO MOLECULAR SIMILAR O INFERIOR PERO ES IMPERMEABLE A LOS COMPONENTES CELULARES Y HUMORALES DEL SISTEMA INMUNOLOGICO DEL CUERPO.
ES93922765T 1992-10-19 1993-09-28 Pancreas biohibrido artificial implantable y rellenable. Expired - Lifetime ES2111775T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/962,879 US5262055A (en) 1992-10-19 1992-10-19 Implantable and refillable biohybrid artificial pancreas

Publications (1)

Publication Number Publication Date
ES2111775T3 true ES2111775T3 (es) 1998-03-16

Family

ID=25506457

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93922765T Expired - Lifetime ES2111775T3 (es) 1992-10-19 1993-09-28 Pancreas biohibrido artificial implantable y rellenable.

Country Status (12)

Country Link
US (1) US5262055A (es)
EP (1) EP0664729B1 (es)
JP (1) JPH08504615A (es)
KR (1) KR100266833B1 (es)
AT (1) ATE162423T1 (es)
AU (1) AU5166193A (es)
CA (1) CA2147261A1 (es)
DE (1) DE69316636T2 (es)
DK (1) DK0664729T3 (es)
ES (1) ES2111775T3 (es)
GR (1) GR3026399T3 (es)
WO (1) WO1994008702A1 (es)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI923023A7 (fi) * 1990-10-31 1992-06-29 Baxter Int Lähellään tapahtuvan verisuonittumisen aikaansaava istutemateriaali
US5713888A (en) * 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5545223A (en) * 1990-10-31 1996-08-13 Baxter International, Inc. Ported tissue implant systems and methods of using same
US6231881B1 (en) * 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US6352707B1 (en) 1992-02-24 2002-03-05 Anton-Lewis Usala Transplant encapsulation in a hydrogel matrix to obscure immune recognition
JPH08503715A (ja) * 1993-09-24 1996-04-23 バクスター、インターナショナル、インコーポレイテッド 埋め込み装置の血管化を促進するための方法
US5549675A (en) * 1994-01-11 1996-08-27 Baxter International, Inc. Method for implanting tissue in a host
US6090400A (en) * 1994-02-07 2000-07-18 The Trustees Of The Childhood Diabetes Transplant Research Trust Pharmaceutical preparation and method for treatment of diabetes
US6156305A (en) * 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
CA2214088A1 (en) * 1995-03-03 1996-09-12 Metabolex Inc. Novel encapsulation process by a gelling polymer
AU5390696A (en) * 1995-04-20 1996-11-07 University Of South Florida Purified and isolated sertoli cell aggregate
ES2175101T3 (es) * 1995-06-05 2002-11-16 Baxter Int Sistema de carga de tejido para dispositivos biologicos implantables.
US5820917A (en) * 1995-06-07 1998-10-13 Medtronic, Inc. Blood-contacting medical device and method
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US5702444A (en) * 1995-09-11 1997-12-30 Struthers, Mehta And Maxwell Implantable artificial endocrine pancreas
EP0955948B1 (en) * 1995-10-26 2005-06-15 Paul P. Latta Induction of immunological tolerance
EP0986402A2 (en) * 1997-06-06 2000-03-22 Battelle Memorial Institute Reversible geling co-polymer and method of making
US20040228794A1 (en) * 1998-04-10 2004-11-18 Battelle Memorial Institute Therapeutic agent carrier compositions
US6296831B1 (en) 1998-04-10 2001-10-02 Battelle Memorial Institute Stimulus sensitive gel with radioisotope and methods of making
US7422601B2 (en) * 1999-08-02 2008-09-09 University Of Chicago Office Of Technology Transfer Method for inducing hypothermia
US6962601B2 (en) 1999-08-02 2005-11-08 University Of Chicago Office Of Technology Transfer Method for inducing hypothermia
EP1207807A4 (en) 1999-08-02 2005-12-28 Lance B Becker PROCESS FOR INDUCING HYPOTHERMIA
IL134009A (en) * 2000-01-12 2011-07-31 Bo2 Technologies Ltd Transplant device
US8012500B2 (en) * 2000-01-01 2011-09-06 Beta-O2 Technologies Ltd. Implantable device
WO2001085900A2 (en) * 2000-05-05 2001-11-15 Mcgill University A device for cell implantation
CA2410965C (en) 2000-05-31 2010-09-14 Encelle, Inc. Method of stimulating hair growth
US6511473B2 (en) * 2001-01-30 2003-01-28 Biodepo, Inc. Implantable bioartificial active secretion system
KR100431536B1 (ko) * 2001-02-14 2004-05-20 박상규 ｐＨ변화를 이용한 식품 품질 식별표시계
JP2004530431A (ja) * 2001-06-08 2004-10-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 免疫隔離装置内の細胞株活性を改善する方法
EP1539033A1 (en) * 2002-08-07 2005-06-15 Memry Corporation Implantable artificial pancreas
AU2003294541A1 (en) * 2002-12-24 2004-07-22 An-Go-Gen Inc. Encapsulated cell for therapy
US20040185013A1 (en) * 2003-01-30 2004-09-23 Burgio Paul A. Dental whitening compositions and methods
US20040151691A1 (en) * 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
US7223826B2 (en) * 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
US20040197374A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Implantable pouch seeded with insulin-producing cells to treat diabetes
US7820158B2 (en) * 2003-04-10 2010-10-26 Surmodics, Inc. Ligand-coupled initiator polymers and methods of use
US20060036302A1 (en) * 2004-05-28 2006-02-16 Kasza Kenneth E Methods of inducing protective hypothermia of organs
US9788978B2 (en) * 2004-12-20 2017-10-17 Nicholas A. Rojo Implantable systems and stents containing cells for therapeutic uses
US20060161232A1 (en) * 2005-01-18 2006-07-20 Kasza, Oras and Son to The University of Chicago Phase-change particulate ice slurry coolant medical delivery tubing and insertion devices
CA2610646C (en) * 2005-06-02 2012-09-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Prevascularized devices and related methods
US7389653B2 (en) * 2005-09-15 2008-06-24 The University Of Chicago Medical ice slurry production device
US20100068264A1 (en) * 2006-07-12 2010-03-18 University Of South Florida Niosome-hydrogel drug delivery system
DE102006042732B3 (de) * 2006-09-12 2008-04-10 Gerlach, Jörg, Dr.med. Künstliches arterio-venöses permeables Hohlfaserkapillarsystem
AU2007297776A1 (en) * 2006-09-21 2008-03-27 Tissue Genesis, Inc. Cell delivery matrices
ES2659988T3 (es) * 2006-11-28 2018-03-20 Beta O2 Technologies Ltd. Suministro de oxígeno para el transplante celular y la vascularización
WO2008112190A1 (en) * 2007-03-09 2008-09-18 The University Of Akron Bio-artificial pancreas and a procedure for preparation of same
US8821431B2 (en) 2007-09-07 2014-09-02 Beta O2 Technologies Ltd. Air gap for supporting cells
US20090110656A1 (en) * 2007-10-31 2009-04-30 Lemke Sarah A Skin cooling composition
US20090157153A1 (en) * 2007-12-13 2009-06-18 Sarah Anne Lemke Skin cooling system
US20090324693A1 (en) 2008-06-30 2009-12-31 Kimberly-Clark Worldwide, Inc. Delivery Product for Topical Compositions
US9540630B2 (en) * 2008-09-17 2017-01-10 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
JP2012508584A (ja) * 2008-11-14 2012-04-12 ヴィアサイト，インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
US8043271B2 (en) * 2008-11-26 2011-10-25 Beta 02 Technologies Ltd. Apparatus for transportation of oxygen to implanted cells
US10287539B2 (en) * 2009-06-09 2019-05-14 Jtec Corporation Rotating culture vessel and automatic cell culture apparatus using same
PL2470228T3 (pl) 2009-08-28 2018-03-30 Sernova Corporation Sposoby i urządzenia do przeszczepiania komórek
US8784389B2 (en) * 2009-08-31 2014-07-22 Beta-O2 Technologies Ltd. Oxygen supply for implantable medical device
WO2011109712A2 (en) 2010-03-04 2011-09-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Bioengineered human corneal stromal tissue
FR2960783B1 (fr) 2010-06-04 2012-07-27 Ass Pour Les Transferts De Technologies Du Mans Membrane fonctionnalisee pour chambre d'encapsulation de cellules produisant au moins une substance d'interet therapeutique et organe bioartificiel comprenant une telle membrane
WO2011154941A2 (en) 2010-06-07 2011-12-15 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
FR2962898B1 (fr) 2010-07-22 2012-08-17 Statice Sante Poche pour former un organe artificiel implantable
JP6158821B2 (ja) * 2011-11-24 2017-07-05 クック・バイオテック・インコーポレイテッドＣｏｏｋ Ｂｉｏｔｅｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ 修飾可能な医療用移植片ならびに関連する方法および機器
US20130158472A1 (en) * 2011-12-16 2013-06-20 JaiShankar Raman Subcutaneous Controlled Delivery System For The Topical Administration Of Drugs, Biological Agents Or Therapeutic Agents To Targeted Areas Within The Body
US9101707B2 (en) 2012-04-27 2015-08-11 Gregory Zeltser Implantable bioartificial perfusion system
US9522114B1 (en) 2014-03-27 2016-12-20 University Of South Florida Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin
EP3206567A1 (en) 2014-10-13 2017-08-23 Glusense, Ltd. Analyte-sensing device
KR101681542B1 (ko) * 2015-03-10 2016-12-01 메디키네틱스 주식회사 인공췌장 구현을 위한 교환형 카트리지 장치
EP3445872A1 (en) 2016-04-20 2019-02-27 Glusense Ltd. Fret-based glucose-detection molecules
EP3318294A1 (en) * 2016-11-08 2018-05-09 Defymed Kit for in situ delivery of a compound of interest
US12016327B2 (en) * 2017-03-20 2024-06-25 Boston Scientific Medical Device Limited Cell encapsulation device
EP3428264A1 (en) 2017-07-12 2019-01-16 Defymed Non-foldable pouch for forming an implantable artificial organ
US11534283B2 (en) * 2017-09-06 2022-12-27 Children's National Medical Center Porous implantable devices
CN108659807B (zh) * 2018-07-12 2020-09-01 西安交通大学 一种智能纳米泡沫驱油剂的制备方法
CN112654331A (zh) 2018-08-22 2021-04-13 波士顿科学国际有限公司 包括多孔管的细胞包封装置
AU2020256224B2 (en) * 2019-04-03 2025-09-25 Vertex Pharmaceuticals Incorporated Multicompartment macroencapsulation devices
WO2021061940A1 (en) 2019-09-27 2021-04-01 Isla Technologies, Inc. Bioartificial pancreas
US12485274B2 (en) 2021-03-08 2025-12-02 Samsung Electronics Co., Ltd. Apparatus and method with electrical stimulus
US20240197464A1 (en) * 2021-04-27 2024-06-20 Sanofi Implantable Device and Therapeutic System with Passive Oxygenation
WO2024091534A1 (en) * 2022-10-25 2024-05-02 The Regents Of The University Of Michigan Implantable encapsulated device with controlled perfusion that generates reprogrammed cells
WO2025226588A1 (en) * 2024-04-22 2025-10-30 Wake Forest University Health Sciences Artificial implants that promote neovascularization

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531333B1 (fr) * 1982-08-09 1986-04-04 Centre Nat Rech Scient Pancreas bio-artificiel a ultrafiltration
JPH0489000A (ja) * 1990-05-02 1992-03-23 W R Grace & Co 細胞培養キットおよび細胞傷害試験法
EP0470681A3 (en) * 1990-08-08 1992-04-22 W.R. Grace & Co.-Conn. Cell clusters or sheets comprising a plurality of cell species and preparations thereof
EP0499932A1 (en) * 1991-02-16 1992-08-26 W.R. Grace & Co.-Conn. Cancer cell cluster comprising cancer cells and normal cells and preparation thereof

Also Published As

Publication number Publication date
DK0664729T3 (da) 1998-09-21
WO1994008702A1 (en) 1994-04-28
US5262055A (en) 1993-11-16
EP0664729A1 (en) 1995-08-02
EP0664729A4 (en) 1996-03-27
JPH08504615A (ja) 1996-05-21
DE69316636T2 (de) 1998-05-07
ATE162423T1 (de) 1998-02-15
EP0664729B1 (en) 1998-01-21
DE69316636D1 (de) 1998-02-26
KR950703399A (ko) 1995-09-20
KR100266833B1 (ko) 2000-09-15
GR3026399T3 (en) 1998-06-30
AU5166193A (en) 1994-05-09
CA2147261A1 (en) 1994-04-28

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