ES2112151B1 - Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos. - Google Patents

Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos.

Info

Publication number
ES2112151B1
ES2112151B1 ES9500553A ES9500553A ES2112151B1 ES 2112151 B1 ES2112151 B1 ES 2112151B1 ES 9500553 A ES9500553 A ES 9500553A ES 9500553 A ES9500553 A ES 9500553A ES 2112151 B1 ES2112151 B1 ES 2112151B1
Authority
ES
Spain
Prior art keywords
compounds
homoquiral
preparation
new
theronazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9500553A
Other languages
English (en)
Other versions
ES2112151A1 (es
Inventor
Garcia Pelayo Camps
Torrecabota Xavier Farres
Casellas David Mauleon
Germano Carganico
Perez M Luisa Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES9500553A priority Critical patent/ES2112151B1/es
Priority to AU50039/96A priority patent/AU5003996A/en
Priority to PCT/EP1996/000972 priority patent/WO1996029325A1/en
Publication of ES2112151A1 publication Critical patent/ES2112151A1/es
Application granted granted Critical
Publication of ES2112151B1 publication Critical patent/ES2112151B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NUEVOS COMPUESTOS HOMOQUIRALES PARA LA PREPARACION DE KETOCONAZOL, TERCONAZOL Y ANTIFUNGICOS RELACIONADOS, PROCEDIMIENTO PARA SU FABRICACION Y UTILIZACION DE LOS MISMOS. LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS HOMOQUIRALES QUE SON INTERMEDIOS EN LA PREPARACION DE DIVERSOS ANTIFUNGICOS AZOLICOS DE FORMULA V EN FORMA ENANTIOMERICAMENTE PURA, DONDE AR ES UN GRUPO FENILO O FENILO SUSTITUIDO, DE MODO QUE EL GRUPO FENILO SUSTITUIDO PUEDE CONTENER DE UNO A TRES SUSTITUYENTES, CADA UNO DE LOS CUALES INDEPENDIENTEMENTE PUEDE SER FLUOR, CLORO, BROMO, (C1-C4)-ALQUILO O (C1-C4)-ALQUILOXI; Y ES UNA AGRUPACION CH O UN ATOMO DE NITROGENO; Z ES UN GRUPO COCH3, CH(CH3)2 O DE IGUAL MODO LA PRESENTE INVENCION SE REFIERE A LOS PROPIOS COMPUESTOS (+)- TERCONAZOL Y (-)-TERCONAZOL. DICHOS COMPUESTOS PRESENTAN ACTIVIDAD ANTIFUNGICA Y ANTIBACTERIANA, PUDIENDO SER UTILIZADOS EN TERAPIA HUMANA Y EN VETERINARIA.
ES9500553A 1995-03-17 1995-03-17 Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos. Expired - Lifetime ES2112151B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9500553A ES2112151B1 (es) 1995-03-17 1995-03-17 Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos.
AU50039/96A AU5003996A (en) 1995-03-17 1996-03-07 Homochiral compounds for the preparation of ketoconazole, terconazole and related antifungal drugs
PCT/EP1996/000972 WO1996029325A1 (en) 1995-03-17 1996-03-07 Homochiral compounds for the preparation of ketoconazole, terconazole and related antifungal drugs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9500553A ES2112151B1 (es) 1995-03-17 1995-03-17 Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos.

Publications (2)

Publication Number Publication Date
ES2112151A1 ES2112151A1 (es) 1998-03-16
ES2112151B1 true ES2112151B1 (es) 1999-09-16

Family

ID=8289834

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9500553A Expired - Lifetime ES2112151B1 (es) 1995-03-17 1995-03-17 Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos.

Country Status (3)

Country Link
AU (1) AU5003996A (es)
ES (1) ES2112151B1 (es)
WO (1) WO1996029325A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998021204A1 (en) 1996-11-12 1998-05-22 Sepracor, Inc. 2r,4s,s,s- and 2s,4r,s,s-hydroxyitraconazole
CN1237174A (zh) * 1996-11-12 1999-12-01 塞普拉科公司 2r,4s,s,r－和2s,4r,s,r－羟基伊曲康唑
AU5251398A (en) * 1996-11-12 1998-06-03 Sepracor, Inc. (2r,4s,r,r-) and (2s,4r,r,r-)hydroxyitraconazole
EP2803357B1 (en) 2004-06-25 2020-11-18 The Johns-Hopkins University Angiogenesis inhibitors
MX2009012739A (es) * 2007-05-25 2009-12-10 Janssen Pharmaceutica Nv Sintesis mejorada del metansulfonato(ester) de (2s-cis)-2-(bromometil)-2-(4-clorofenil)-1,3-dioxolan-4-metanol.
WO2010013510A1 (ja) * 2008-08-01 2010-02-04 ダイソー株式会社 光学活性化合物の製造方法
EP3858357A1 (en) 2020-01-28 2021-08-04 Diaccurate Use of azole compounds to stimulate the immune system and as inhibitors for s-pla2gib
WO2024105519A1 (en) * 2022-11-14 2024-05-23 Piramal Pharma Limited A process for the preparation of levoketoconazole
CN116854657A (zh) * 2023-07-04 2023-10-10 浙江东亚药业股份有限公司 一种酮康唑中间体顺式溴代酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3039087A1 (de) * 1980-10-16 1982-05-19 Hoechst Ag, 6000 Frankfurt 1-(1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung
EP0052905B1 (en) * 1980-11-24 1984-10-03 Janssen Pharmaceutica N.V. Novel (2-aryl-4-phenylthioalkyl-1,3-dioxolan-2-yl-methyl)azole derivatives
CA2117651C (en) * 1992-03-18 2006-01-03 Jan Heeres Itraconazole and saperconazole stereoisomers
US5208331A (en) * 1992-06-18 1993-05-04 Syntex (U.S.A.) Inc. Process for preparing 1,3-dioxolane derivatives
US5403937A (en) * 1993-04-30 1995-04-04 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents

Also Published As

Publication number Publication date
WO1996029325A1 (en) 1996-09-26
ES2112151A1 (es) 1998-03-16
AU5003996A (en) 1996-10-08

Similar Documents

Publication Publication Date Title
ES2186015T3 (es) Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol.
BR9302435A (pt) Composto de pirazol,processo para a preparacao do mesmo e composicao farmaceutica
ES2128791T3 (es) Derivados espirocetales, composiciones que los contienen y su uso como agentes terapeuticos.
ES2112151B1 (es) Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos.
ES2162061T3 (es) Derivados de piperidina como antagonistas de la neuroquinina.
ES2167377T3 (es) Derivados de piridina farmacologicamente activos y procedimientos para la preparacion de los mismos.
SV1999000016A (es) Derivados de 2-(purin-9-il-tetrahidrofuran-3,4-diol ref. pg3443/sv
ES2157424T3 (es) Esteres de acido 5-aminolevulinico como agentes fotosensibilizantes en fotoquimioterapia.
ES2115985T3 (es) Dihidropirazolopirroles.
MX9308042A (es) Pirazoles y pirazolopirimidinas.
AR003955A1 (es) Derivados de n-(indol-2-carbonil)-glicinamidas, procedimiento para su obtencion y composiciones que los contienen.
NO20075065L (no) Anvendelse av isoflavonforbindelser til a behandle hjertesykdom
SV1999000009A (es) Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol ref. pg3388/sv
CY1110019T1 (el) Συνδυασμενη θεραπεια με υποκατεστημενες οξαζολιδινονες
ES2131842T3 (es) Compuestos de triazol y su empleo como ligandos de dopamina-d3.
PA8432901A1 (es) Compuestos de piridilpirrol
ES2037013T3 (es) Procedimiento para preparar tieno-1,4-diazepinas.
CY1107199T1 (el) Καρβαμικες ενωσεις για χρηση στη προληψη ή τη θεραπευτικη αντιμετωπιση της διπολικης διαταραχης
ES2187518T3 (es) 3-(aminoalquilamino)-1-2-benzisoxazoles sustituidos y compuestos relacionados.
SE9702564D0 (sv) New compounds
ES2159734T3 (es) Derivados 2-heteroarilalquenilicos del acido ciclopentano-heptan(en)oico como agentes terapeuticos para el tratamiento de la hipertension ocular.
ES2134777T3 (es) Nuevos compuestos de sulfonilo.
ES2078749T3 (es) Procedimiento para preparar sertralina.
ES2064328T3 (es) Indolilpropanoles, procedimiento para su fabricacion y su uso, asi como preparaciones que contienen los compuestos.
ES2166830T3 (es) Derivados 2,7-sustituidos de octahidro-1h-pirido(1,2-a)pirazina.

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 19980316

Kind code of ref document: A1

Effective date: 19980316

FA2A Application withdrawn

Effective date: 20001102