ES2112338T3 - Anticuerpos estabilizados. - Google Patents

Anticuerpos estabilizados.

Info

Publication number
ES2112338T3
ES2112338T3 ES92922609T ES92922609T ES2112338T3 ES 2112338 T3 ES2112338 T3 ES 2112338T3 ES 92922609 T ES92922609 T ES 92922609T ES 92922609 T ES92922609 T ES 92922609T ES 2112338 T3 ES2112338 T3 ES 2112338T3
Authority
ES
Spain
Prior art keywords
immunoglobulin
pct
copper ions
sec
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92922609T
Other languages
English (en)
Inventor
Marjorie Smith
Valentina Riveros-Rojas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10703637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2112338(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2112338T3 publication Critical patent/ES2112338T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

LA INVENCION SE REFIERE A UNA COMPOSICION DE INMUNOGLOBULINA ESTABILIZADA QUE CONTIENE AL MENOS UNA INMUNOGLOBULINA JUNTO CON UNA CANTIDAD ESTABILADORA DE UN AGENTE QUELANTE DE IONES DE COBRE TAL COMO EDTA O CITRATO. PREFERENTEMENTE, LA INMUNOGLOBULINA ES UN ANTICUERPO, POR EJEMPLO UN ANTICUERPO INJERTADO CON CDR RECOMBINANTE CONTRA EL ANTIGENO CDW52, Y MEJOR AUN CAMPATH UMENTAR LA ESTABILIDAD DE UNA INMUNOGLOBULINA QUE CONSISTE EN SOMETER A LA INMUNOGLOBULINA A UN PROCESO DE PURIFICACION CAPAZ DE SEPARAR LOS IONES DE COBRE DE LA MISMA. PREFERENTEMENTE SE HACE QUE LA INMUNOGLOBULINA NO TENGA SUSTANCIALMENTE IONES DE COBRE DETECTABLES, POR EJEMPLO MEDIANTE UNA ESPECTROSCOPIA DE ABSORCION ATOMICA.
ES92922609T 1991-10-28 1992-10-27 Anticuerpos estabilizados. Expired - Lifetime ES2112338T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919122820A GB9122820D0 (en) 1991-10-28 1991-10-28 Stabilised antibodies

Publications (1)

Publication Number Publication Date
ES2112338T3 true ES2112338T3 (es) 1998-04-01

Family

ID=10703637

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92922609T Expired - Lifetime ES2112338T3 (es) 1991-10-28 1992-10-27 Anticuerpos estabilizados.

Country Status (17)

Country Link
US (2) US5654403A (es)
EP (1) EP0612251B1 (es)
JP (1) JP2881499B2 (es)
AT (1) ATE161191T1 (es)
AU (1) AU674290B2 (es)
CA (1) CA2121257C (es)
DE (1) DE69223641T2 (es)
DK (1) DK0612251T3 (es)
ES (1) ES2112338T3 (es)
GB (1) GB9122820D0 (es)
GR (1) GR3025931T3 (es)
HK (1) HK1004325A1 (es)
IL (1) IL103560A (es)
MY (1) MY110207A (es)
SG (1) SG47905A1 (es)
WO (1) WO1993008837A1 (es)
ZA (1) ZA928296B (es)

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US20020035107A1 (en) * 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
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JP2013505938A (ja) * 2009-09-24 2013-02-21 エックスバイオテク，インコーポレイテッド 抗抗体応答を軽減する方法、組成物およびキット
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KR102167261B1 (ko) 2010-06-18 2020-10-20 엑스바이오테크, 인크. 관절염 치료
US10294296B2 (en) 2010-08-23 2019-05-21 Xbiotech, Inc. Treatment for neoplastic diseases
EP2444101A1 (en) 2010-10-21 2012-04-25 Universitätsklinikum Freiburg Selective targeting of the CD40L/Mac-1 interaction by small peptide inhibitors and its use for the treatment of inflammation and atherogenesis
SG190069A1 (en) 2010-11-11 2013-06-28 Abbvie Biotechnology Ltd IMPROVED HIGH CONCENTRATION ANTI-TNFa ANTIBODY LIQUID FORMULATIONS
US9724409B2 (en) 2011-04-01 2017-08-08 Xbiotech, Inc. Treatment of inflammatory skin disease
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Also Published As

Publication number Publication date
IL103560A (en) 1998-02-08
ATE161191T1 (de) 1998-01-15
GB9122820D0 (en) 1991-12-11
ZA928296B (en) 1994-04-28
AU2872992A (en) 1993-06-07
EP0612251B1 (en) 1997-12-17
US5654403A (en) 1997-08-05
AU674290B2 (en) 1996-12-19
DE69223641T2 (de) 1998-04-09
JPH07502497A (ja) 1995-03-16
CA2121257C (en) 1999-07-13
EP0612251A1 (en) 1994-08-31
IL103560A0 (en) 1993-03-15
JP2881499B2 (ja) 1999-04-12
US5792838A (en) 1998-08-11
HK1004325A1 (en) 1998-11-20
SG47905A1 (en) 1998-04-17
WO1993008837A1 (en) 1993-05-13
DE69223641D1 (de) 1998-01-29
CA2121257A1 (en) 1993-05-13
DK0612251T3 (da) 1998-04-27
MY110207A (en) 1998-02-28
GR3025931T3 (en) 1998-04-30

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