ATE490787T1 - Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion - Google Patents
Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktionInfo
- Publication number
- ATE490787T1 ATE490787T1 AT04747833T AT04747833T ATE490787T1 AT E490787 T1 ATE490787 T1 AT E490787T1 AT 04747833 T AT04747833 T AT 04747833T AT 04747833 T AT04747833 T AT 04747833T AT E490787 T1 ATE490787 T1 AT E490787T1
- Authority
- AT
- Austria
- Prior art keywords
- igm
- production
- quantifying
- transformed cells
- chain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48733303P | 2003-07-15 | 2003-07-15 | |
| PCT/JP2004/010444 WO2005005636A1 (ja) | 2003-07-15 | 2004-07-15 | 形質転換細胞によるIgMの産生とその定量方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490787T1 true ATE490787T1 (de) | 2010-12-15 |
Family
ID=34062150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04747833T ATE490787T1 (de) | 2003-07-15 | 2004-07-15 | Produktion von igm durch transformierte zellen und verfahren zur quantifizierung dieser igm- produktion |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7709615B2 (de) |
| EP (2) | EP2204190A1 (de) |
| JP (1) | JP5452835B2 (de) |
| AT (1) | ATE490787T1 (de) |
| AU (1) | AU2004256354B2 (de) |
| CA (1) | CA2532966C (de) |
| DE (1) | DE602004030451D1 (de) |
| TW (1) | TW200510532A (de) |
| WO (1) | WO2005005636A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200510532A (en) | 2003-07-15 | 2005-03-16 | Chugai Pharmaceutical Co Ltd | IgM production by transformed cell and method of quantifying the same |
| US7803914B2 (en) | 2003-10-09 | 2010-09-28 | Chugai Seiyaku Kabushiki Kaisha | Methods for stabilizing protein solutions |
| JP4762717B2 (ja) | 2003-10-09 | 2011-08-31 | 中外製薬株式会社 | IgM高濃度安定化溶液 |
| DK1835022T3 (en) | 2005-01-05 | 2015-02-23 | Chugai Pharmaceutical Co Ltd | CELL CULTIVATION PROCEDURE AND UTILIZATION OF THIS |
| WO2007002676A2 (en) * | 2005-06-27 | 2007-01-04 | Invitrogen Corporation | Liquid protein markers for native gel electrophoresis |
| FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| EP1977763A4 (de) | 2005-12-28 | 2010-06-02 | Chugai Pharmaceutical Co Ltd | Antikörper-enthaltende stabilisierende zubereitung |
| ES2409844T3 (es) * | 2006-01-30 | 2013-06-28 | Grifols Therapeutics Inc. | Metodo para el tratamiento y la profilaxis de enfermedades relacionadas con la deposicion de amiloide utilizando IgM |
| CL2007001665A1 (es) | 2006-06-08 | 2008-01-18 | Chugai Pharmaceutical Co Ltd | Anticuerpo o fragmento del mismo con actividad neutralizante de la proteina nr 10; agente que lo comprende; y su uso para prevenir o tratar una enfermedad inflamatoria. |
| HU0700534D0 (en) | 2006-11-24 | 2007-10-29 | Mezoegazdasagi Biotechnologiai | Transgenic animal with enhanced immune response and method for the preparation thereof |
| BRPI0818674B1 (pt) | 2007-10-15 | 2023-01-17 | Chugai Seiyaku Kabushiki Kaisha | Métodos para produção de um anticorpo inteiro ou de um fragmento do mesmo e para preparação de fármacos, bem como vetor recombinante |
| MY185647A (en) | 2007-12-05 | 2021-05-27 | Chugai Pharmaceutical Co Ltd | Therapeutic agent for pruritus |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| CN102164962B (zh) * | 2008-06-30 | 2014-05-28 | 诺福泰克公司 | 抗gd2抗体和方法及其相关应用 |
| JP5232241B2 (ja) * | 2008-10-31 | 2013-07-10 | 独立行政法人科学技術振興機構 | ヘルパーt細胞の選択的機能制御法 |
| TWI505838B (zh) | 2010-01-20 | 2015-11-01 | 中外製藥股份有限公司 | Stabilized antibody solution containing |
| WO2013012022A1 (ja) | 2011-07-19 | 2013-01-24 | 中外製薬株式会社 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
| CA2847302C (en) | 2011-09-01 | 2021-02-16 | Chugai Seiyaku Kabushiki Kaisha | Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration |
| ES2655077T3 (es) * | 2012-04-17 | 2018-02-16 | Mayo Foundation For Medical Education And Research | Anticuerpos humanos y secuencias de unión específicos del mismo para uso en accidente cerebrovascular e isquemia y condiciones isquémicas |
| CA2888652C (en) * | 2012-11-30 | 2020-09-22 | Katinger Gmbh | Recombinant human igm-antibody effective against cancer cells |
| US20140199319A1 (en) * | 2012-12-14 | 2014-07-17 | Abbvie, Inc. | Methods for increasing the efficiency of hybridoma generation |
| EP4671270A3 (de) | 2013-12-27 | 2026-03-18 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur reinigung eines antikörpers mit niedrigem isoelektrischen punkt |
| KR102380402B1 (ko) | 2014-04-03 | 2022-03-31 | 아이쥐엠 바이오사이언스 인코포레이티드 | 변형된 j-사슬 |
| EP3185004A4 (de) | 2014-08-20 | 2018-05-30 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur messung der viskosität einer proteinlösung |
| EP3750918A1 (de) | 2015-01-20 | 2020-12-16 | IGM Biosciences, Inc. | Tumornekrosefaktor-superfamilienrezeptorbindende moleküle und verwendungen davon |
| CN115093479A (zh) | 2015-03-04 | 2022-09-23 | Igm生物科学股份有限公司 | Cd20结合分子及其用途 |
| JP6882184B2 (ja) * | 2015-03-25 | 2021-06-02 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価b型肝炎ウイルス抗原結合分子およびその使用 |
| US11639389B2 (en) | 2015-09-30 | 2023-05-02 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
| DK3355913T3 (da) | 2015-09-30 | 2024-12-02 | Igm Biosciences Inc | Bindingsmolekyler med modificeret j-kæde |
| US10572893B2 (en) | 2016-06-16 | 2020-02-25 | International Business Machines Corporation | Discovering and interacting with proximate automobiles |
| CN112512480B (zh) | 2018-05-21 | 2024-10-01 | 中外制药株式会社 | 被封入玻璃容器的冷冻干燥制剂 |
| EP3805112A4 (de) | 2018-05-28 | 2022-03-09 | Chugai Seiyaku Kabushiki Kaisha | Fülldüse |
| EP4003333A4 (de) * | 2019-07-31 | 2023-11-01 | The Wistar Institute for Anatomy and Biology | Multivalente dna-antikörperkonstrukte und ihre verwendung |
| US20230212293A1 (en) * | 2020-04-22 | 2023-07-06 | Igm Biosciences, Inc. | Pd-1 agonist multimeric binding molecules |
| EP4297786A4 (de) * | 2021-02-23 | 2025-01-22 | Pandion Operations, Inc. | Pd-1-antikörper, polypeptide und verwendungen davon |
| WO2023244276A2 (en) * | 2021-10-13 | 2023-12-21 | The Wistar Institute Of Anatomy And Biology | DNA ENCODED ANTIBODIES WITH Fc MODIFICATIONS |
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| US5156840A (en) | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| ATE82136T1 (de) | 1987-08-10 | 1992-11-15 | Miles Inc | Gereinigtes igm. |
| US5157113A (en) | 1987-08-10 | 1992-10-20 | Miles Inc. | Removal of nucleic acids from monoclonal antibody preparations |
| GB8719963D0 (en) * | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
| CA1312030C (en) | 1987-11-18 | 1992-12-29 | Brian Maiorella | Method to increase antibody titer |
| US6238891B1 (en) | 1987-11-18 | 2001-05-29 | Cetus Oncology Corporation | Method of increasing product expression through solute stress |
| JP2501116B2 (ja) | 1988-03-05 | 1996-05-29 | 日本電信電話株式会社 | 巡回制御形回線交換方法 |
| DE3825429C2 (de) | 1988-07-27 | 1994-02-10 | Biotest Pharma Gmbh | Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt |
| GB9010944D0 (en) | 1990-05-16 | 1990-07-04 | Central Blood Lab Authority | Chemical compounds |
| US5419904A (en) * | 1990-11-05 | 1995-05-30 | The Regents Of The University Of California | Human B-lymphoblastoid cell line secreting anti-ganglioside antibody |
| EP0492409A1 (de) * | 1990-12-18 | 1992-07-01 | Ishihara Sangyo Kaisha, Ltd. | Menschlicher monoklonaler Antikörper |
| JPH05192181A (ja) | 1990-12-18 | 1993-08-03 | Ishihara Sangyo Kaisha Ltd | ヒトモノクローナル抗体 |
| JPH0565233A (ja) | 1991-03-08 | 1993-03-19 | Mitsui Toatsu Chem Inc | モノクローナル抗体含有凍結乾燥製剤 |
| AU660981B2 (en) * | 1991-03-12 | 1995-07-13 | Astellas Us Llc | CD2-binding domain of lymphocyte function associated antigen 3 |
| ES2134212T3 (es) | 1991-04-25 | 1999-10-01 | Chugai Pharmaceutical Co Ltd | Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano. |
| JPH04360696A (ja) * | 1991-06-06 | 1992-12-14 | Sumitomo Chem Co Ltd | 新規なヒトbリンパ細胞株を宿主として産生された組み換えヒト抗体 |
| GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
| JP3565572B2 (ja) | 1992-09-07 | 2004-09-15 | 協和醗酵工業株式会社 | ヒト化抗体 |
| AU669379B2 (en) * | 1992-09-07 | 1996-06-06 | Kyowa Hakko Kirin Co., Ltd. | Humanized antibodies |
| JPH06178689A (ja) * | 1992-12-11 | 1994-06-28 | Mitsui Toatsu Chem Inc | I型緑膿菌を抗原とするヒト抗体をコードする遺伝子 |
| JPH06189781A (ja) | 1992-12-25 | 1994-07-12 | Mitsui Toatsu Chem Inc | 培養液中の生理活性タンパク質の安定化方法 |
| JPH09127112A (ja) | 1995-10-30 | 1997-05-16 | Dainabotsuto Kk | 修飾IgM免疫学的測定試薬 |
| JPH09127114A (ja) | 1995-11-01 | 1997-05-16 | Dainabotsuto Kk | 免疫学的測定用安定化IgM試薬 |
| AU730457B2 (en) | 1996-08-16 | 2001-03-08 | President And Fellows Of Harvard College | Soluble monovalent and multivalent MHC class II fusion proteins, and uses therefor |
| EP0835880A1 (de) | 1996-10-14 | 1998-04-15 | Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk | Verfahren zur Herstellung eines IgM Präparates für die intravenöse Applikation |
| JPH10324699A (ja) * | 1997-03-21 | 1998-12-08 | Sankyo Co Ltd | 抗ヒトFasヒト化抗体 |
| MY131805A (en) | 1997-09-18 | 2007-09-28 | Biogen Idec Inc | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis. |
| EP1047457A2 (de) | 1998-01-16 | 2000-11-02 | MCA Development B.V. | Radiomarkierte monoklones igm zür therapie von krebs und autoimmunkrankheit |
| WO1999037329A1 (en) | 1998-01-22 | 1999-07-29 | Astrazeneca Ab | Pharmaceutical formulation comprising an antibody and a citrate buffer |
| JP2002504342A (ja) * | 1998-02-19 | 2002-02-12 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 一価mhc結合ドメイン融合タンパク質および接合体、多価mhc結合ドメイン融合タンパク質および接合体、ならびに多量体mhc結合ドメイン融合タンパク質および接合体、そしてそれらのための使用 |
| JP2000154149A (ja) * | 1998-09-18 | 2000-06-06 | Sankyo Co Ltd | 抗ヒトFasヒト化抗体含有抗リウマチ剤 |
| EE05111B1 (et) * | 1998-10-16 | 2008-12-15 | Biogen, Incorporated | Interferoon-beetaga sulandatud valgud ja nende kasutamine |
| EP1176195B1 (de) | 1999-04-09 | 2013-05-22 | Kyowa Hakko Kirin Co., Ltd. | Verfahren zur kontrolle der aktivität von immunologisch funktionellem molekül |
| CA2371427A1 (en) | 1999-04-28 | 2000-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Parenteral pharmaceutical composition containing humanized monoclonal antibody fragment and stabilizing method thereof |
| AU7449200A (en) | 1999-09-30 | 2001-04-30 | Kyowa Hakko Kogyo Co. Ltd. | Derivatives of antibody against ganglioside gm2 |
| EP1226752A4 (de) | 1999-11-05 | 2004-05-06 | Kyowa Hakko Kogyo Kk | Transgene nicht-humane tiere zur überwachung einer veränderung der kalzium-ionenkonzentration in zellen |
| ES2637801T3 (es) * | 2000-04-11 | 2017-10-17 | Genentech, Inc. | Anticuerpos multivalentes y usos de los mismos |
| US6586785B2 (en) | 2000-06-29 | 2003-07-01 | California Institute Of Technology | Aerosol silicon nanoparticles for use in semiconductor device fabrication |
| US20040081972A1 (en) | 2000-08-01 | 2004-04-29 | Mitsuo Satoh | Novel physiologically active peptide and use thereof |
| GB0113179D0 (en) | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| JP2003128576A (ja) * | 2001-10-25 | 2003-05-08 | Taisho Pharmaceut Co Ltd | エンドトキシン誘発性疾患治療薬 |
| AU2002356749A1 (en) | 2001-11-28 | 2003-06-10 | Hermann Katinger | Process for the production of polypeptides in mammalian cell cultures |
| DE10328295B4 (de) | 2003-06-23 | 2007-11-22 | Endress + Hauser Gmbh + Co. Kg | Verfahren und entsprechende Vorrichtung zum Schweißen von Bauteilen eines Feldgerätes |
| WO2005003557A1 (en) | 2003-06-25 | 2005-01-13 | Design Net Engineering, Llc | Laser propulsion thruster |
| TW200510532A (en) | 2003-07-15 | 2005-03-16 | Chugai Pharmaceutical Co Ltd | IgM production by transformed cell and method of quantifying the same |
| JP4762717B2 (ja) | 2003-10-09 | 2011-08-31 | 中外製薬株式会社 | IgM高濃度安定化溶液 |
| US7803914B2 (en) | 2003-10-09 | 2010-09-28 | Chugai Seiyaku Kabushiki Kaisha | Methods for stabilizing protein solutions |
-
2004
- 2004-07-15 TW TW093121127A patent/TW200510532A/zh not_active IP Right Cessation
- 2004-07-15 WO PCT/JP2004/010444 patent/WO2005005636A1/ja not_active Ceased
- 2004-07-15 EP EP10150954A patent/EP2204190A1/de not_active Withdrawn
- 2004-07-15 DE DE602004030451T patent/DE602004030451D1/de not_active Expired - Lifetime
- 2004-07-15 AU AU2004256354A patent/AU2004256354B2/en not_active Expired
- 2004-07-15 AT AT04747833T patent/ATE490787T1/de not_active IP Right Cessation
- 2004-07-15 EP EP04747833A patent/EP1652925B1/de not_active Expired - Lifetime
- 2004-07-15 CA CA2532966A patent/CA2532966C/en not_active Expired - Lifetime
- 2004-07-15 US US10/564,665 patent/US7709615B2/en not_active Expired - Lifetime
- 2004-07-15 JP JP2005511621A patent/JP5452835B2/ja not_active Expired - Lifetime
-
2010
- 2010-03-18 US US12/727,162 patent/US8257703B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TWI342336B (de) | 2011-05-21 |
| AU2004256354B2 (en) | 2011-07-07 |
| EP1652925A1 (de) | 2006-05-03 |
| AU2004256354A1 (en) | 2005-01-20 |
| EP1652925A4 (de) | 2007-07-04 |
| US20100172899A1 (en) | 2010-07-08 |
| WO2005005636A1 (ja) | 2005-01-20 |
| DE602004030451D1 (de) | 2011-01-20 |
| TW200510532A (en) | 2005-03-16 |
| JP5452835B2 (ja) | 2014-03-26 |
| US8257703B2 (en) | 2012-09-04 |
| CA2532966C (en) | 2012-12-04 |
| US20070154469A1 (en) | 2007-07-05 |
| EP1652925B1 (de) | 2010-12-08 |
| CA2532966A1 (en) | 2005-01-20 |
| EP2204190A1 (de) | 2010-07-07 |
| JPWO2005005636A1 (ja) | 2006-08-24 |
| US7709615B2 (en) | 2010-05-04 |
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