ES2113376T3 - Conjugados de anticuerpos para tratamiento de enfermedades neoplasticas. - Google Patents

Conjugados de anticuerpos para tratamiento de enfermedades neoplasticas.

Info

Publication number
ES2113376T3
ES2113376T3 ES91909732T ES91909732T ES2113376T3 ES 2113376 T3 ES2113376 T3 ES 2113376T3 ES 91909732 T ES91909732 T ES 91909732T ES 91909732 T ES91909732 T ES 91909732T ES 2113376 T3 ES2113376 T3 ES 2113376T3
Authority
ES
Spain
Prior art keywords
treatment
antibody conjugates
neoplastic diseases
diseases
zme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91909732T
Other languages
English (en)
Inventor
Michael G Rosenblum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Development Foundation
Original Assignee
Research Development Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Development Foundation filed Critical Research Development Foundation
Application granted granted Critical
Publication of ES2113376T3 publication Critical patent/ES2113376T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6865—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6821—Plant heterodimeric toxins, e.g. abrin or modeccin
    • A61K47/6823—Double chain ricin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE PRESENTAN INMUNOCONJUGADOS DE UN ANTICUERPO PARA UN ANTIGENO ASOCIADO CON EL TUMOR MELANOMA 240 KD. INMUNOCONJUGADOS CITOTOXICOS TALES COMO EL CONJUGADO DEL ANTICUERPO ZME-018 SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES DE CELULAS PROLIFERATIVAS TALES COMO EL MELANOMA ASI COMO OTROS TUMORES QUE SOPORTAN EL ANTIGENO ZME-018. TAMBIEN SE PRESENTAN COMPUETOS DETECTABLEMENTE ETIQUETADOS PARA LA DIAGNOSIS DE TALES ENFERMEDADES.
ES91909732T 1990-04-19 1991-04-19 Conjugados de anticuerpos para tratamiento de enfermedades neoplasticas. Expired - Lifetime ES2113376T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51092390A 1990-04-19 1990-04-19

Publications (1)

Publication Number Publication Date
ES2113376T3 true ES2113376T3 (es) 1998-05-01

Family

ID=24032743

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91909732T Expired - Lifetime ES2113376T3 (es) 1990-04-19 1991-04-19 Conjugados de anticuerpos para tratamiento de enfermedades neoplasticas.

Country Status (23)

Country Link
US (1) US20050214307A1 (es)
EP (1) EP0525119B1 (es)
JP (1) JP3340127B2 (es)
KR (1) KR100212372B1 (es)
CN (1) CN1071579C (es)
AT (1) ATE164078T1 (es)
AU (1) AU650267B2 (es)
CA (1) CA2079902C (es)
DE (1) DE69129109T2 (es)
DK (1) DK0525119T3 (es)
ES (1) ES2113376T3 (es)
FI (1) FI104234B1 (es)
HK (1) HK1008418A1 (es)
IE (1) IE62496B1 (es)
IL (1) IL97776A (es)
NO (1) NO317485B1 (es)
NZ (1) NZ237688A (es)
PT (1) PT97423B (es)
RU (1) RU2119352C1 (es)
SA (1) SA91120208B1 (es)
TW (1) TW211573B (es)
WO (1) WO1991016071A1 (es)
ZA (1) ZA912490B (es)

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CA2072249C (en) * 1991-06-28 2003-06-17 Saiko Hosokawa Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
ZA932522B (en) * 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
US5632982A (en) * 1994-06-07 1997-05-27 The Board Of Trustees Of The Leland Stanford Junior University Cytotoxic enhancement of TNF with copper
PT706799E (pt) * 1994-09-16 2002-05-31 Merck Patent Gmbh Imunoconjugados ii
RU2196823C2 (ru) * 2000-12-26 2003-01-20 Институт прикладной механики РАН Способ иммобилизации биологически активных веществ на матрицах пористых носителей
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
CA2454048C (en) 2001-07-17 2011-05-03 Research Development Foundation Therapeutic agents comprising pro-apoptotic proteins
JP2006506964A (ja) * 2002-06-12 2006-03-02 リサーチ　ディベロップメント　ファンデーション 治療剤としての免疫毒素及びその利用
JP4989850B2 (ja) * 2002-10-25 2012-08-01 アメリカ合衆国 ＴＧＦ−βの遮断により腫瘍再発を防ぐ方法
JP2008528633A (ja) * 2005-02-01 2008-07-31 リサーチ ディベロップメント ファウンデーション Ｂｌｙｓレセプターを標的化するためのｂｌｙｓ融合タンパク質およびｂ細胞増殖性疾患の処置方法
US20080267964A1 (en) * 2005-02-17 2008-10-30 Masaki Terabe Synergistic Effect of Tgf-Beta Blockade and Immunogenic Agents on Tumors
EP1956899B1 (en) * 2005-11-02 2015-09-09 Oplon, Pure Science Ltd Compositions and methods for cell killing
KR20090013752A (ko) * 2006-03-16 2009-02-05 헬스 리서치 인코포레이티드 유방암 줄기세포 성장 및 전이 억제
KR20150006000A (ko) 2012-05-01 2015-01-15 제넨테크, 인크. 항-pmel17 항체 및 면역접합체
CN110251683A (zh) * 2013-06-24 2019-09-20 Abl生物公司 具有改进的稳定性的抗体-药物缀合物及其用途
EP3261678B8 (en) 2015-01-23 2021-03-17 Helix Biopharma Corp. Antibody-urease conjugates for therapeutic purposes
US11458172B2 (en) 2017-09-08 2022-10-04 New Portal Limited Nucleic acid systems that enable bacteria to specifically target solid tumors via glucose-dependent viability
CN110455903A (zh) * 2018-05-07 2019-11-15 天士力生物医药股份有限公司 一种注射用重组人尿激酶原杂质分析的梯度电泳检测方法
WO2022006748A1 (en) 2020-07-07 2022-01-13 New Portal Limited Genetically engineered live bacteria and methods of constructing the same

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FR2504010B1 (fr) * 1981-04-15 1985-10-25 Sanofi Sa Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
US4522918A (en) * 1981-12-15 1985-06-11 Jeffery Schlom Process for producing monoclonal antibodies reactive with human breast cancer
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
FR2546756B1 (fr) * 1983-06-03 1985-11-29 Centre Nat Rech Scient Nouveaux derives immunostimulants, leur preparation et leur application comme medicament
US4753894A (en) * 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
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JP2006506964A (ja) * 2002-06-12 2006-03-02 リサーチ　ディベロップメント　ファンデーション 治療剤としての免疫毒素及びその利用

Also Published As

Publication number Publication date
IL97776A0 (en) 1992-06-21
EP0525119A4 (en) 1993-09-15
PT97423B (pt) 1998-10-30
EP0525119A1 (en) 1993-02-03
KR100212372B1 (ko) 1999-08-02
JP3340127B2 (ja) 2002-11-05
KR930700140A (ko) 1993-03-13
CA2079902C (en) 2001-08-28
RU2119352C1 (ru) 1998-09-27
SA91120208B1 (ar) 2006-03-01
US20050214307A1 (en) 2005-09-29
NO924025L (no) 1992-10-16
DK0525119T3 (da) 1998-11-23
IL97776A (en) 2000-10-31
CA2079902A1 (en) 1991-10-20
FI924605L (fi) 1992-10-12
WO1991016071A1 (en) 1991-10-31
FI104234B (fi) 1999-12-15
ATE164078T1 (de) 1998-04-15
NZ237688A (en) 1993-01-27
AU7892291A (en) 1991-11-11
FI924605A0 (fi) 1992-10-12
TW211573B (es) 1993-08-21
IE62496B1 (en) 1995-02-08
AU650267B2 (en) 1994-06-16
EP0525119B1 (en) 1998-03-18
DE69129109T2 (de) 1998-07-02
JPH06502617A (ja) 1994-03-24
NO317485B1 (no) 2004-11-08
CN1055879A (zh) 1991-11-06
ZA912490B (en) 1992-12-30
DE69129109D1 (de) 1998-04-23
PT97423A (pt) 1992-01-31
HK1008418A1 (en) 1999-05-07
FI104234B1 (fi) 1999-12-15
CN1071579C (zh) 2001-09-26
NO924025D0 (no) 1992-10-16
IE911122A1 (en) 1991-10-23

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