ES2113860T3 - Peptidos con grupos tioles de cisteina protegidos, utiles en los ensayos inmunologicos. - Google Patents

Peptidos con grupos tioles de cisteina protegidos, utiles en los ensayos inmunologicos.

Info

Publication number
ES2113860T3
ES2113860T3 ES90911054T ES90911054T ES2113860T3 ES 2113860 T3 ES2113860 T3 ES 2113860T3 ES 90911054 T ES90911054 T ES 90911054T ES 90911054 T ES90911054 T ES 90911054T ES 2113860 T3 ES2113860 T3 ES 2113860T3
Authority
ES
Spain
Prior art keywords
peptides
protected
thyol
useful
immunological tests
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90911054T
Other languages
English (en)
Inventor
James Blake
Carol-Ann Cole
Patrick Coleman
Nobuo Monji
John P Montana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetic Systems Corp
Original Assignee
Genetic Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp
Application granted granted Critical
Publication of ES2113860T3 publication Critical patent/ES2113860T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PEPTIDOS INMUNOREACTIVOS CON ANTICUERPOS PARA LAS PROTEINAS NATIVAS, Y QUE POSEEN AL MENOS DOS RESIDUOS CISTEINAS QUE CONTRIBUYEN A MIMETIZAR UN EPITOPE DE LA PROTEINA, PREPARADOS CON LOS GRUPOS DE TIOL CISTEINA PROTEGIDOS. CUANDO SE DESPROTEGEN, LOS PEPTIDOS HAN AUMENTADO LA INMUNOREACTIVIDAD. LOS PEPTIDOS SON PARTICULARMENTE UTILES PARA DETECTAR ANTICUERPOS O ANTIGENOS ASOCIADOS CON RETROVIRUS, INCLUYENDO LOS RETROVIRUS LINFOTROPICOS CLINICAMENTE IMPORTANTES HIV-1, HIV-2, HTLV-I, Y HTLV-II.
ES90911054T 1989-06-02 1990-06-04 Peptidos con grupos tioles de cisteina protegidos, utiles en los ensayos inmunologicos. Expired - Lifetime ES2113860T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36051389A 1989-06-02 1989-06-02
PCT/US1990/003148 WO1990015071A1 (en) 1989-06-02 1990-06-04 Cysteine thiol-protected peptides for use in immunoassays

Publications (1)

Publication Number Publication Date
ES2113860T3 true ES2113860T3 (es) 1998-05-16

Family

ID=23418295

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90911054T Expired - Lifetime ES2113860T3 (es) 1989-06-02 1990-06-04 Peptidos con grupos tioles de cisteina protegidos, utiles en los ensayos inmunologicos.

Country Status (12)

Country Link
EP (1) EP0474789B1 (es)
JP (1) JP3404035B2 (es)
KR (1) KR960013600B1 (es)
AT (1) ATE162799T1 (es)
AU (1) AU652919B2 (es)
CA (1) CA2056381C (es)
DE (1) DE69032009T2 (es)
DK (1) DK0474789T3 (es)
ES (1) ES2113860T3 (es)
FI (1) FI102834B (es)
NO (1) NO304151B1 (es)
WO (1) WO1990015071A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083504A (en) * 1989-08-24 2000-07-04 Bioclonetics Incorporated Human monoclonal antibodies directed against the transmembrane glycoprotein (GP41) of human immunodeficiency virus-1 (HIV-1)
US5459060A (en) * 1989-08-24 1995-10-17 Bioclonetics Incorporated Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of human immunodeficiency virus-1 (HIV-1)
US6008044A (en) * 1989-08-24 1999-12-28 Bioclonetics Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of human immunodeficiency virus-1 (HIV-1) and detection of antibodies against epitope (GCSGKLIC)
DE69129207T2 (de) * 1990-01-16 1998-10-08 Orgenics Ltd Peptide, von Virus-HIV-Hüllen-Glycoproteinen abstammend, deren Verwendung zum Nachweis einer Infektion dieser Viren und für die Impfung gegen AIDS
BR0015170A (pt) * 1999-10-27 2002-06-25 Innogenetics Nv Proteìnas de hcv com oxirredução reversìvel e conformação similar à nativa
JP5182069B2 (ja) * 2008-12-24 2013-04-10 Ｊｎｃ株式会社 チオール基を有する刺激応答性磁性微粒子及びその利用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4111924A (en) * 1976-01-05 1978-09-05 Takeda Chemical Industries, Ltd. Method for removal of thiol-protecting groups
FR2525592B1 (es) * 1982-04-26 1984-09-14 Pasteur Institut
US4689398A (en) * 1984-06-20 1987-08-25 Ortho Diagnostic Systems Inc. HTLV test using synthetic peptides
JPS63502904A (ja) * 1986-03-24 1988-10-27 オ−ソ・フア−マシユ−チカル・コ−ポレ−シヨン 合成ｈｔｌｖ−３ペプチド、その組成物及び用途
EP0247557B1 (en) * 1986-05-27 1994-04-20 F. Hoffmann-La Roche Ag HTLV-III(LAV) Envelope peptides
GB8828097D0 (en) * 1988-12-01 1989-01-05 Wellcome Found Peptides

Also Published As

Publication number Publication date
JP3404035B2 (ja) 2003-05-06
NO304151B1 (no) 1998-11-02
NO914725L (no) 1992-01-29
FI102834B1 (fi) 1999-02-26
CA2056381A1 (en) 1990-12-03
WO1990015071A1 (en) 1990-12-13
DE69032009D1 (de) 1998-03-05
FI102834B (fi) 1999-02-26
EP0474789A1 (en) 1992-03-18
DK0474789T3 (da) 1998-09-28
AU6053290A (en) 1991-01-07
AU652919B2 (en) 1994-09-15
JPH04505623A (ja) 1992-10-01
KR920701236A (ko) 1992-08-11
FI915649A0 (fi) 1991-11-29
ATE162799T1 (de) 1998-02-15
KR960013600B1 (ko) 1996-10-09
NO914725D0 (no) 1991-11-29
EP0474789A4 (en) 1992-06-03
CA2056381C (en) 2000-08-22
DE69032009T2 (de) 1998-07-23
EP0474789B1 (en) 1998-01-28

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