ES2114721T3 - Procedimiento para preparar intermedios derivados del acido benzoico y agentes farmaceuticos benzotiofenos. - Google Patents

Procedimiento para preparar intermedios derivados del acido benzoico y agentes farmaceuticos benzotiofenos.

Info

Publication number
ES2114721T3
ES2114721T3 ES95306050T ES95306050T ES2114721T3 ES 2114721 T3 ES2114721 T3 ES 2114721T3 ES 95306050 T ES95306050 T ES 95306050T ES 95306050 T ES95306050 T ES 95306050T ES 2114721 T3 ES2114721 T3 ES 2114721T3
Authority
ES
Spain
Prior art keywords
benzotiofen
procedure
benzoic acid
pharmaceutical agents
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95306050T
Other languages
English (en)
Inventor
Douglas Patton Kjell
Fred Mason Perry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2114721T3 publication Critical patent/ES2114721T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO PROCESO PARA PREPARAR NUEVOS COMPUESTOS DE LA FORMULA (I) EN LA QUE R1 Y R2 SON CADA UNA INDEPENDIENTEMENTE ALQUILO C{SUB, 1-4}, O SE COMBINAN PARA FORMAR PIPERIDINILO, PIRROLIDINILO, METILPIRROLIDINILO, DIMETILPIRROLIDINILO, MORFOLINO, DIMETILAMINO, DIALQUILAMINO O 1-HEXAMETILENOIMINO; Y N ES 2 O 3; TAMBIEN SE PRESENTA UNA SAL FARMACOLOGICAMENTE ACEPTABLE DEL MISMO, EL PROCESO COMPRENDE A) LA REACCION DE UN HALOALQUILAMINO CON UN COMPUESTO DE LA FORMULA (IV) EN LA PRESENCIA DE UN SOLVENTE DE ACETATO DE ALQUILO Y UNA BASE; B) LA EXTRACCION DEL PRODUCTO DE LA REACCION DEL PASO A) CON UN ACIDO ACUOSO; Y C) LA DIVISION DEL ESTER DEL PRODUCTO DE LA REACCION DEL PASO B) PARA FORMAR UN ACIDO. LA INVENCION SUMINISTRA ADEMAS UN NUEVO PROCESO PARA PREPARAR LOS COMPUESTOS DE LA FORMULA (V).
ES95306050T 1994-08-31 1995-08-30 Procedimiento para preparar intermedios derivados del acido benzoico y agentes farmaceuticos benzotiofenos. Expired - Lifetime ES2114721T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/298,636 US5631369A (en) 1994-08-31 1994-08-31 Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Publications (1)

Publication Number Publication Date
ES2114721T3 true ES2114721T3 (es) 1998-06-01

Family

ID=23151367

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95306050T Expired - Lifetime ES2114721T3 (es) 1994-08-31 1995-08-30 Procedimiento para preparar intermedios derivados del acido benzoico y agentes farmaceuticos benzotiofenos.

Country Status (17)

Country Link
US (2) US5631369A (es)
EP (1) EP0699672B1 (es)
JP (1) JPH08119964A (es)
KR (1) KR100359959B1 (es)
AT (1) ATE165355T1 (es)
BR (1) BR9503846A (es)
CA (1) CA2157236A1 (es)
CY (1) CY2092B1 (es)
DE (1) DE69502152T2 (es)
DK (1) DK0699672T3 (es)
ES (1) ES2114721T3 (es)
FI (1) FI114706B (es)
GR (1) GR3026742T3 (es)
HK (1) HK1006912A1 (es)
HU (2) HU222121B1 (es)
IL (1) IL115092A0 (es)
TW (1) TW427975B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002514174A (ja) * 1996-08-28 2002-05-14 イーライ・リリー・アンド・カンパニー 非晶質ベンゾチオフェン類、製造方法および使用方法
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
US7124425B1 (en) * 1999-03-08 2006-10-17 Immersion Entertainment, L.L.C. Audio/video system and method utilizing a head mounted apparatus with noise attenuation
WO2001023369A2 (en) * 1999-09-27 2001-04-05 Eli Lilly And Company Process for preparing benzoic acids
FR2817865B1 (fr) * 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
EP1832583A1 (en) 2002-09-30 2007-09-12 A/S GEA Farmaceutisk Fabrik Novel raloxifene sulphuric acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these
US7012153B2 (en) * 2003-12-22 2006-03-14 Eli Lilly And Company Process for preparing benzoic acids
JP5508003B2 (ja) 2006-06-30 2014-05-28 アイスイティカ ピーティーワイ リミテッド ナノ粒子状の形態における生物学的に活性な化合物の調製のための方法
NZ710384A (en) 2009-04-24 2017-03-31 Iceutica Pty Ltd A novel formulation of indomethacin
CA2759109A1 (en) 2009-04-24 2010-10-28 Iceutica Pty Ltd A solid dosage form of ciprofloxacin having small particle size and improved powder handling characteristics
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
KR102117214B1 (ko) 2020-03-26 2020-06-01 유지씨 주식회사 에어 리스 스프레이 건 용 도료 비산 방지 커버 하우징
KR102145873B1 (ko) 2020-06-10 2020-08-20 유지씨 주식회사 에어 리스 스프레이건 용 도료 비산 방지 커버 하우징 및 그 비산 방지 커버 하우징이 결합 된 고소작업대용 도색장치 및 그 비산 방지 커버 하우징이 결합 된 달비계용 도색 장치 및 그 비산 방지 커버 하우징이 결합 된 평면용 도색장치
KR102227020B1 (ko) 2020-12-18 2021-03-12 유지씨 주식회사 스프레이 건 용 도료 비산 방지 커버 하우징 결합체
KR102444617B1 (ko) 2021-05-28 2022-09-16 이다지 도장용 스프레이건의 비산방지장치
KR102607000B1 (ko) 2023-03-24 2023-11-29 이다지 도장용 스프레이 건의 비산방지장치

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
GB2097788B (en) * 1981-04-03 1985-04-24 Lilly Co Eli Benzothiophene compounds and process for preparing them
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US4656187A (en) * 1981-08-03 1987-04-07 Eli Lilly And Company Treatment of mammary cancer
CA2020887A1 (en) * 1989-07-28 1991-01-29 Michael Klaus Aromatic carboxylic amides

Also Published As

Publication number Publication date
FI954067A7 (fi) 1996-03-01
DK0699672T3 (da) 1998-10-07
HU9502537D0 (en) 1995-10-30
FI114706B (fi) 2004-12-15
GR3026742T3 (en) 1998-07-31
US5631369A (en) 1997-05-20
JPH08119964A (ja) 1996-05-14
CA2157236A1 (en) 1996-03-01
HK1006912A1 (en) 1999-03-19
KR960007543A (ko) 1996-03-22
IL115092A0 (en) 1995-12-08
US5750688A (en) 1998-05-12
TW427975B (en) 2001-04-01
CY2092B1 (en) 2002-04-05
ATE165355T1 (de) 1998-05-15
DE69502152T2 (de) 1998-09-17
KR100359959B1 (ko) 2003-01-14
FI954067A0 (fi) 1995-08-30
HUT73141A (en) 1996-06-28
HU222121B1 (hu) 2003-04-28
BR9503846A (pt) 1996-09-17
HU0003473D0 (es) 1995-08-30
DE69502152D1 (de) 1998-05-28
EP0699672B1 (en) 1998-04-22
EP0699672A1 (en) 1996-03-06

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