ES2114948T3 - Compuestos disminuidores del colesterol y procedimiento para prepararlos. - Google Patents

Compuestos disminuidores del colesterol y procedimiento para prepararlos.

Info

Publication number
ES2114948T3
ES2114948T3 ES92921189T ES92921189T ES2114948T3 ES 2114948 T3 ES2114948 T3 ES 2114948T3 ES 92921189 T ES92921189 T ES 92921189T ES 92921189 T ES92921189 T ES 92921189T ES 2114948 T3 ES2114948 T3 ES 2114948T3
Authority
ES
Spain
Prior art keywords
preparing
hydroxymethylhexose
sterol
procedure
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921189T
Other languages
English (en)
Inventor
Adam Wieslaw Mazur
Stanislaw Pikul
Bruce Paul Daggy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of ES2114948T3 publication Critical patent/ES2114948T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE DESCRIBEN UNA NUEVAS SAPONIFICADORAS QUE CONTIENEN 5-CHIDROXIMETILHEXOSA Y UN ESTEROL O TRITERPENA. ESTOS MATERIALES, CUANDO SON CONSUMIDOS POR LOS HUMANOS Y ANIMALES, REDUCEN EL NIVEL DE COLESTEROL EN LA SANGRE. LOS COMPUESTOS SE PUEDEN ADMINISTRAR COMO PREPARACION FARMACEUTICA A LA DIETA, O INCORPORADOS EN COMPOSICIONES ALIMENTICIAS. LAS COMPOSICIONES ESTAN LISTAS AL PREPARARLAS Y LUEGO HACER REACCIONAR FLUOR O BROMO 5-C-HIDROXIMETILHEXOSA HEXAACILATADA CON EL ESTEROL. EN UN SEGUNDO METODO LA 5-C-HIDROXIMETILHEXOSA HEXAACILATADA REACCIONA CON UN ESTEROL EN PRESENCIA DE UN SULFONATO TRIFLUOROMETANO TRIMETILSILILO.
ES92921189T 1991-10-04 1992-09-29 Compuestos disminuidores del colesterol y procedimiento para prepararlos. Expired - Lifetime ES2114948T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77166891A 1991-10-04 1991-10-04
US77170991A 1991-10-04 1991-10-04

Publications (1)

Publication Number Publication Date
ES2114948T3 true ES2114948T3 (es) 1998-06-16

Family

ID=27118506

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921189T Expired - Lifetime ES2114948T3 (es) 1991-10-04 1992-09-29 Compuestos disminuidores del colesterol y procedimiento para prepararlos.

Country Status (9)

Country Link
EP (1) EP0607245B1 (es)
JP (1) JPH06511250A (es)
AT (1) ATE165367T1 (es)
AU (1) AU2753292A (es)
DE (1) DE69225233T2 (es)
ES (1) ES2114948T3 (es)
GR (1) GR3026698T3 (es)
PT (1) PT100922B (es)
WO (1) WO1993007167A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ331094A3 (en) * 1992-06-26 1995-09-13 Pfizer Steroidal glycosides and their use for treating hypercholesterolemia and atherosclerosis
EP0696292A1 (en) * 1993-04-28 1996-02-14 Pfizer Inc. Spirostanyl glycosidal crystalline monohydrate
US5502038A (en) * 1993-06-21 1996-03-26 Medical Research Foundation Of Oregon Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption
ES2074006B1 (es) * 1993-07-05 1996-03-16 Pfizer Glicosidos esteroidales para tratar hipercolesterolemia.
WO1996038466A1 (en) * 1995-05-29 1996-12-05 Pfizer Inc. Steroidal glycosides
US5756470A (en) * 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
WO2001032679A2 (en) * 1999-11-01 2001-05-10 Forbes Medi-Tech Inc. Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
PT1355644E (pt) 2001-01-26 2006-11-30 Schering Corp Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
RS20100015A (sr) 2001-01-26 2010-12-31 Schering Corporation Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
FI20010780A0 (fi) 2001-04-12 2001-04-12 Raisio Benecol Oy Parannetut koostumukset
EP1429756B1 (en) 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
JP2006508188A (ja) 2002-11-06 2006-03-09 シェーリング　コーポレイション 脱髄の処置のためのコレステロール吸収インヒビター
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
DE602004016123D1 (de) 2003-03-07 2008-10-09 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
NZ599945A (en) 2009-11-02 2014-05-30 Pfizer Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
KR102149572B1 (ko) 2014-05-19 2020-08-28 화이자 인코포레이티드 아시알로당단백질 수용체의 표적화제로서 치환된-6,8-다이옥사바이사이클로[3.2.1]옥탄-2,3-다이올 화합물
CN107531798B (zh) 2015-03-20 2022-02-18 奥胡斯大学 Pcsk9的抑制剂用于脂蛋白代谢病症的治疗
ES2871783T3 (es) * 2016-09-20 2021-11-02 Univ Aarhus Compuestos para el tratamiento de trastornos del metabolismo de las lipoproteínas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602005A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis
US5041541A (en) * 1988-05-05 1991-08-20 The Procter & Gamble Company Functional sugar substituted with reduced calories

Also Published As

Publication number Publication date
GR3026698T3 (en) 1998-07-31
EP0607245B1 (en) 1998-04-22
WO1993007167A1 (en) 1993-04-15
PT100922B (pt) 1999-08-31
DE69225233D1 (de) 1998-05-28
ATE165367T1 (de) 1998-05-15
AU2753292A (en) 1993-05-03
DE69225233T2 (de) 1998-11-19
EP0607245A1 (en) 1994-07-27
PT100922A (pt) 1993-10-29
JPH06511250A (ja) 1994-12-15

Similar Documents

Publication Publication Date Title
GR3026698T3 (en) Cholesterol lowering compounds and process for making them.
DK214790A (da) Naeringspraeparat og fremgangsmaade til fremstilling deraf
KR880010764A (ko) 과콜레스테롤혈중 치료용 혼합물
NO162741C (no) Belagt diettfiber og fremgangsmaate for fremstilling av enslik diettfiber.
PT71727B (en) Process for preparing a pharmaceutical composition particularly suitable for cancer treatment
DE69205192D1 (de) Gluciden enthaltend Zusammenstellungen zur Diät und Therapie und ihre Verwendungen.
DE2964963D1 (en) Medical food based on liver powder and process for its preparation
PT77898A (en) Process for the preparation of substituted 4-amino-methylenochromanes and 4-aminomethylenecromenes acting on the blood circulation and application thereof in the preparation of pharmaceutical compositions acting on the blood circulation
SE7906467L (sv) Hypo-beta-lipoproteinemiskt dietikum, forfarande for framstellning derav och anvendning derav
JPS57122085A (en) Circulatory disease extirpenter and use
DE3373675D1 (en) Process for the preparation of peroxydated fats by biological low energy transformation, products obtained by this process, mixtures of these products with additives and new medicines made up of these products
ZA861459B (en) Pharmaceutical and dietary compositions
ES2016917A6 (es) Producto alimenticio y procedimiento para preparar productos alimenticios con konjak anadido.
DE3068585D1 (en) Derivatives of 3,4,5-trihydroxypiperidine, processes for their preparation, and their use as medicines and in animal food
Bosaeus et al. Short-term effect of two cholesterol-lowering diets on sterol excretion in ileostomy patients
RU92016194A (ru) Способ приготовления майонеза
IL60323A0 (en) Pseudotrisaccharide compounds,their preparation and their medicinal use
JPS55122718A (en) Preparation of health drink
JPS54110210A (en) Preparation of oil for meat-roasting hot plate
ATE2746T1 (de) Piperidinderivate von 4,5-dialkyl-3-hydroxypyrrol-2-carbons[ureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
Zechmeister et al. Stereochemical configuration and provitamin A activity. X. A comparison of synthetic 15, 15′-monocis-β-carotene (central monocis-β-carotene) with all-trans-β-carotene in the rat and chick
JPS57198066A (en) Preparation of white sauce
Slavin et al. Determination and apparent digestibility of neutral detergent fiber monosaccharides in women
JPS5233903A (en) Preparation of refined natural food oil
JPS5590504A (en) Preparation of unsoluble chitin derivative

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 607245

Country of ref document: ES