ES2115054T3 - Inhibicion de la hipotension y del shock septico, causados por oxido nitrico, mediante el uso de hemoproteina conteniendo hierro. - Google Patents

Inhibicion de la hipotension y del shock septico, causados por oxido nitrico, mediante el uso de hemoproteina conteniendo hierro.

Info

Publication number
ES2115054T3
ES2115054T3 ES93905917T ES93905917T ES2115054T3 ES 2115054 T3 ES2115054 T3 ES 2115054T3 ES 93905917 T ES93905917 T ES 93905917T ES 93905917 T ES93905917 T ES 93905917T ES 2115054 T3 ES2115054 T3 ES 2115054T3
Authority
ES
Spain
Prior art keywords
nitric oxide
septic shock
caused
hypotension
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93905917T
Other languages
English (en)
Inventor
Robert G Kilbourn
Angelo Joseph De
Joseph Bonaventura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apex Bioscience Inc
The University of Texas System
The University of Texas at Austin
Duke University
Original Assignee
Apex Bioscience Inc
The University of Texas System
The University of Texas at Austin
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apex Bioscience Inc, The University of Texas System, The University of Texas at Austin, Duke University filed Critical Apex Bioscience Inc
Application granted granted Critical
Publication of ES2115054T3 publication Critical patent/ES2115054T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A UN METODO PARA LA PROFILAXIS O TRATAMIENTO DE UN ANIMAL PARA EFECTOS FISIOLOGICOS DETERIORADOS TALES COMO HIPOTENSION SISTEMICA CAUSADA POR LA PRODUCCION DE OXIDO NITRICO INDUCIDO POR UN MODIFICADOR DE RESPUESTA BIOLOGICA. EJEMPLO DE TALES MODIFICADORES DE RESPUESTA BIOLOGICA COMPRENDEN PERO NO LIMITAN UNA CITOQUINA Y UNA ENDOTOXINA. LA INVENCION SE REFIERE TAMBIEN A UN METODO PARA EL TRATAMIENTO DEL ATAQUE SEPTICO.
ES93905917T 1992-02-19 1993-02-16 Inhibicion de la hipotension y del shock septico, causados por oxido nitrico, mediante el uso de hemoproteina conteniendo hierro. Expired - Lifetime ES2115054T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/838,603 US5296466A (en) 1992-02-19 1992-02-19 Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein

Publications (1)

Publication Number Publication Date
ES2115054T3 true ES2115054T3 (es) 1998-06-16

Family

ID=25277557

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93905917T Expired - Lifetime ES2115054T3 (es) 1992-02-19 1993-02-16 Inhibicion de la hipotension y del shock septico, causados por oxido nitrico, mediante el uso de hemoproteina conteniendo hierro.

Country Status (11)

Country Link
US (6) US5296466A (es)
EP (1) EP0626859B1 (es)
JP (1) JPH07504193A (es)
AT (1) ATE162722T1 (es)
AU (1) AU657212B2 (es)
CA (1) CA2117380C (es)
DE (1) DE69316737T2 (es)
DK (1) DK0626859T3 (es)
ES (1) ES2115054T3 (es)
GR (1) GR3026750T3 (es)
WO (1) WO1993016721A1 (es)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854209A (en) 1995-03-23 1998-12-29 Biopure Corporation Method for oxygenating tissue having reduced red blood cell flow
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US6022849A (en) * 1987-05-16 2000-02-08 Baxter Biotech Technology Saarl Mutant recombinant hemoglobins containing heme pocket mutations
US6204009B1 (en) 1988-05-16 2001-03-20 BAXTER BIOTECH TECHNOLOGY SàRL Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
US5478806A (en) * 1989-11-22 1995-12-26 Enzon, Inc. Enhancement of antitumor therapy with hemoglobin-based conjugates
US5374651A (en) * 1991-09-27 1994-12-20 Board Of Regents, The University Of Texas System Methods and compositions for the treatment of hypotension with arginine free essential and essential amino acids and arginine derivatives
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5296466A (en) * 1992-02-19 1994-03-22 Board Of Regents, The University Of Texas System Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
US7063844B2 (en) 1992-12-10 2006-06-20 The Brigham And Women's Hospital, Inc. Presentation of hydrophobic antigens to T-cells by CD1 molecules
US6238676B1 (en) 1992-12-10 2001-05-29 Brigham And Women's Hospital Presentation of hydrophobic antigens to T-cells by CD1 molecules
GB9309387D0 (en) * 1993-05-06 1993-06-16 Wellcome Found Nitric oxide scavengers
US5686436A (en) * 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5424447A (en) * 1993-07-07 1995-06-13 The Medical College Of Wisconsin Research Foundation, Inc. Heme binding compounds and use thereof
ATE222100T1 (de) * 1993-10-21 2002-08-15 Searle & Co Amidino-derivate nützlich als no synthase-hemmer
AU688811B2 (en) * 1993-10-21 1998-03-19 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
US5364881A (en) * 1993-11-15 1994-11-15 The Medical College Of Wisconsin Research Foundation, Inc. S-alkyl-isothioureido-amino acids and use thereof
DE4338812A1 (de) * 1993-11-15 1995-05-18 Braun Melsungen Ag Verwendung von Lösungen von vernetztem Hämoglobin zur Bekämpfung des septischen und hämorrhagischen Schocks bei Säugetieren
ES2151055T3 (es) * 1994-03-10 2000-12-16 Searle & Co Derivados de l-n6-(1-iminoetil)lisina utiles como inhibidores de oxido nitrico sintasa.
US6245758B1 (en) 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
NZ285648A (en) * 1994-05-13 1999-08-30 Monsanto Co Use of a metal complex as a metal peroxynitrite decomposition catalyst to treat diseases which are affected by accelerated decomposition of peroxynitrite
US5767103A (en) * 1994-05-17 1998-06-16 Research Corporation Tech., Inc. Nitric oxide sequestrant
US5583101A (en) * 1994-07-15 1996-12-10 Harvard College Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction
AU685661B2 (en) * 1994-07-22 1998-01-22 Duke University Human serum albumin-porphyrin complexes with the ability to bind oxygen and therapeutic uses thereof
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
JPH09507867A (ja) * 1994-11-17 1997-08-12 バクスター、インターナショナル、インコーポレイテッド 血液透析におけるヘモグロビン療法
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
WO1996032130A1 (en) * 1995-04-10 1996-10-17 Baxter International Inc. The use of cross-linked hemoglobin in treating subarachnoid hemorrhage
ES2206571T3 (es) * 1995-04-20 2004-05-16 G.D. SEARLE & CO. Agentes de amidino ciclico utiles como inhibidores de la oxido nitrico sintasa.
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US6153186A (en) * 1995-09-15 2000-11-28 Duke University Medical Center Red blood cells loaded with S-nitrosothiol and uses therefor
US6916471B2 (en) * 1995-09-15 2005-07-12 Duke University Red blood cells loaded with S-nitrosothiol and uses therefor
US6855691B1 (en) 1995-09-15 2005-02-15 Duke University Methods for producing and using S-nitrosohemoglobins
US6911427B1 (en) 1995-09-15 2005-06-28 Duke University No-modified hemoglobins and uses therefore
US6197745B1 (en) 1995-09-15 2001-03-06 Duke University Methods for producing nitrosated hemoglobins and therapeutic uses therefor
US6627738B2 (en) 1995-09-15 2003-09-30 Duke University No-modified hemoglobins and uses therefor
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
ZA979540B (en) * 1996-11-12 1998-05-12 Baxter Int Prophylactic use of hemoglobin to prevent sepsis.
US5804551A (en) * 1996-11-12 1998-09-08 Baxter International Inc. Pretraumatic use of hemoglobin
US5970985A (en) * 1996-11-12 1999-10-26 Baxter International, Inc. Use of hemoglobin to treat systemic inflammatory response syndrome
US6054427A (en) * 1997-02-28 2000-04-25 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6645138B2 (en) * 1997-09-12 2003-11-11 Uromedica, Inc. Adjustable implantable genitourinary device
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
US5948609A (en) * 1997-12-03 1999-09-07 Carter; Daniel C. Oxygen-transporting albumin-based blood replacement composition and blood volume expander
CA2333691A1 (en) 1998-06-10 1999-12-16 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
US6448239B1 (en) 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
WO2002009723A2 (en) * 2000-08-01 2002-02-07 Gmp Companies, Inc. Ammonium salts of hemoglobin allosteric effectors, and uses thereof
WO2002010177A1 (en) 2000-08-01 2002-02-07 Gmp Companies, Inc. Ammonium salts of inositol hexaphosphate and uses thereof
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6518010B2 (en) * 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
CA2444590C (en) 2001-04-18 2009-12-01 Robert L. Mcginnis Stabilized hemoglobin solutions
FR2828206B1 (fr) * 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
WO2003015700A2 (en) * 2001-08-15 2003-02-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Novel vasoconstrictor cannabinoid analogs
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US7001715B2 (en) * 2002-02-28 2006-02-21 Biopure Corporation Purification of red blood cells by separation and diafiltration
WO2003092700A1 (en) * 2002-04-29 2003-11-13 Gmp Oxycell, Inc. Inositol pyrophosphates, and methods of use thereof
RU2321860C2 (ru) * 2002-06-21 2008-04-10 Хемофарм Концерн А.Д. Фармацеутско-Хемийска Индустрия Вршац Способ для определения уровня эндотоксина в растворе гемоглобина
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
US20070135389A1 (en) * 2004-07-06 2007-06-14 Claude Nicolau Tumor eradication by inositol-tripyrophosphate
US7745423B2 (en) * 2004-07-06 2010-06-29 NormOxys, Inc Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin
US20060258626A1 (en) * 2004-07-06 2006-11-16 Claude Nicolau Use of inositol-tripyrophosphate in treating tumors and diseases
US20060106000A1 (en) * 2004-07-06 2006-05-18 Claude Nicolau Use of inositol-tripyrophosphate in treating tumors and diseases
US9107917B2 (en) * 2005-05-13 2015-08-18 The Feinstein Institute For Medical Research Treatment of sepsis and inflammation with alpha2A adrenergic antagonists
US7710624B2 (en) * 2005-05-26 2010-05-04 Inphase Technologies, Inc. Controlling the transmission amplitude profile of a coherent light beam in a holographic memory system
EP1978802A2 (en) * 2006-01-24 2008-10-15 Northfield Laboratories, Inc. Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US20090082254A1 (en) * 2006-02-14 2009-03-26 Novo Nordisk A/S Coupling of Polypeptides at the C-Terminus
WO2008094222A2 (en) 2006-10-06 2008-08-07 Trustees Of Princeton Porphyrin catalysts and methods of use thereof
KR20090087900A (ko) * 2006-11-07 2009-08-18 더 제너럴 하스피탈 코포레이션 혈관작용성 산소운반체에 의해 유도되는 혈관수축의 감소
CA2688233A1 (en) * 2007-05-01 2008-11-06 Normoxys, Inc. Erythropoietin complementation or replacement
US20100086530A1 (en) * 2008-10-06 2010-04-08 Martinov Norman P Cancer-tumor necrosis by artery nutrient-oxygen blocking
JP6389125B2 (ja) 2011-11-07 2018-09-12 ザ ジェネラル ホスピタル コーポレイション 赤血球の処理法
DE102013014651A1 (de) * 2013-09-03 2015-03-05 Sanguibiotech Gmbh Zubereitungen zur verbesserten Gewebe-Oxygenierung durch peritoneale Beatmung

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4598064A (en) * 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
US5082642A (en) * 1984-09-10 1992-01-21 Duke University Method for catalyzing oxidation/reduction reactions of simple molecules
US4751068A (en) * 1984-09-10 1988-06-14 Duke University Method for catalyzing oxidation/reduction reactions of simple molecules
US4584130A (en) * 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
US4997812A (en) * 1988-09-12 1991-03-05 Motorola, Inc. Superconducting thick film
DE3838461A1 (de) * 1988-11-12 1990-05-23 Krebsoege Gmbh Sintermetall Pulvermetallurgischer werkstoff auf kupferbasis und dessen verwendung
US5216025A (en) * 1989-09-13 1993-06-01 Board Of Regents, The University Of Texas System Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5296466A (en) * 1992-02-19 1994-03-22 Board Of Regents, The University Of Texas System Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein

Also Published As

Publication number Publication date
DE69316737D1 (de) 1998-03-05
CA2117380A1 (en) 1993-09-02
US5674836A (en) 1997-10-07
EP0626859A1 (en) 1994-12-07
WO1993016721A1 (en) 1993-09-02
US5296466A (en) 1994-03-22
EP0626859B1 (en) 1998-01-28
US6350729B1 (en) 2002-02-26
CA2117380C (en) 2003-04-15
AU3665593A (en) 1993-09-13
AU657212B2 (en) 1995-03-02
US6103690A (en) 2000-08-15
DK0626859T3 (da) 1998-09-21
JPH07504193A (ja) 1995-05-11
US5900403A (en) 1999-05-04
ATE162722T1 (de) 1998-02-15
DE69316737T2 (de) 1998-09-17
GR3026750T3 (en) 1998-07-31
US5480866A (en) 1996-01-02

Similar Documents

Publication Publication Date Title
ATE162722T1 (de) Inhibierung von durch stickstoffmonoxid vermittelte hypotension und von septischem schock mit hämoprotein
ATE263157T1 (de) Nematizide trifluorbutene
DK0791571T3 (da) Benzoylderivater
AP9200410A0 (en) Retroviral protease inhibitors.
AR029288A1 (es) Derivados de 1-sulfonil-pirrolidina
DK0705100T3 (da) Terapeutiske substituerede guanidiner
BE1002196A3 (fr) Traitement bacterien visant a proteger la qualite du foin par addition de micro-organismes du genre bacillus.
DK1109817T3 (da) Phosphohalogenhydriner, deres fremstilling og anvendelse
FI924424A0 (fi) Hjaertskyddande tokoferolanaloger.
ES2114117T3 (es) Acidos fenilalcan(en)oicos con actividad antagonista del leucotrieno b4.
ES2079068T3 (es) 2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas.
NO903148D0 (no) Hemoreguleringspeptider.
EP0387802A3 (en) 5-substituted-1,4-dihydro-4-oxonaphthyridine-3-carboxylate antibacterial agents
ATE88190T1 (de) Zyklisches antikoagulierendes peptid.
ATE91490T1 (de) Zyklisches antikoagulierendes peptid.
DE69416518D1 (de) Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen
EP0577025A3 (de) Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen
FR2575466B1 (fr) Nouveaux complexes de silicium hexacoordines, leur procede de preparation et leur application
ES2133401T3 (es) Utilizacion de farmacos cardiotonicos e inhibidores de sintesis del oxido nitrico para mitigar la hipotension patologica.
ES2066096T3 (es) 4-bencil-5-fenil-2,4-dihidro-3h-1,2,4-triazol-3-onas y su uso como anticonvulsivos.
BG98238A (bg) Заместени бензотиазолови производни,получаванетоим и приложението им като хербициди
DK0571457T3 (da) Iloprost med virkning overfor cerebral malaria.
ES2018716B3 (es) Cemento hidraulico mejorado.
DE3888391D1 (de) Substituierte Silylalkylenamine.
ATE130304T1 (de) Neue alpha-glukosidaseinhibitoren.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 626859

Country of ref document: ES