ES2115269T3 - Empleo de depsipeptidos ciclicos con 12 atomos en el anillo para la lucha contra endoparasitos, nuevos depsipeptidos ciclicos con 12 atomos en el anillo y procedimiento para su obtencion. - Google Patents

Empleo de depsipeptidos ciclicos con 12 atomos en el anillo para la lucha contra endoparasitos, nuevos depsipeptidos ciclicos con 12 atomos en el anillo y procedimiento para su obtencion.

Info

Publication number
ES2115269T3
ES2115269T3 ES95100198T ES95100198T ES2115269T3 ES 2115269 T3 ES2115269 T3 ES 2115269T3 ES 95100198 T ES95100198 T ES 95100198T ES 95100198 T ES95100198 T ES 95100198T ES 2115269 T3 ES2115269 T3 ES 2115269T3
Authority
ES
Spain
Prior art keywords
atoms
depsipeptides
ring
fight against
against endoparasites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95100198T
Other languages
English (en)
Inventor
Jurgen Dr Scherkenbeck
Peter Dr Jeschke
Andrew Dr Plant
Achim Dr Harder
Norbert Dr Mencke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2115269T3 publication Critical patent/ES2115269T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LA UTILIZACION DE DEPSIPEPTIDOS CICLICOS CON 12 ATOMOS DE ANILLO DE LA FORMULA GENERAL (I) DONDE R1 Y R4 INDEPENDIENTE UNO DE OTRO SIGNIFICAN HIDROGENO, ALQUIL DE CADENA RECTA O RAMIFICADA, CICLOALQUIL, ARALQUIL, ARIL, HETEROARIL, HETEROARILALQUIL, QUE SON EVENTUALMENTE SUSTITUIDOS, R2, R3, R5 Y R6 INDEPENDIENTE UNO DE OTRO SIGNIFICAN HIDROGENO, ALQUIL DE CADENA RECTA O RAMIFICADA CON HASTA 8 ATOMOS DE CARBONO, HALOGENALQUIL, HIDROXIALQUIL, ALCANOHIDROXIALQUIL, ALCOXIALQUIL, ARILOXIALQUIL, MERCAPTOALQUIL, ALQUILTIOALQUIL, ALQUILSULFINILALQUIL, ALQUILSULFONIOALQUIL, CARBOXIALQUIL, ALCOXICARBONILALQUIL, ARILALCOXICARBONILALQUIL, CARBAMOILALQUIL, AMINOALQUIL, ALQUILAMINOALQUIL, DIALQUILAMINOALQUIL, GUANIDINOALQUIL, QUE EVENTUALMENTE PUEDE SER SUSTITUIDO POR UNO O DOS RESTO DE BENZILOXICARBONIL O A TRAVES DE 1, 2, 3 O 4 RESTOS ALQUIL, ALCOXICARBONILAMINOALQUIL, 9 - FLUORENILMETOXICARBONIL (FMOC)AMINOALQUIL, ALQUENIL, CICLOALQUIL, CICLOALQUILALQUIL ASI COMO ARILALQUIL EVENTUALMENTE SUSTITUIDO POR ARIL, HETEROARIL, HERTOARILALQUIL. ASI COMO SUS ISOMEROS OPTICOS Y RACEMATOS PARA LA LUCHA CONTRA ENDOPARASITOS EN LA MEDICINA Y EN VETERINARIA, NUEVO DEPSIPEPTIDO CON 12 ATOMOS DE ANILLO Y PROCESO PARA SU ELABORACION.
ES95100198T 1994-01-19 1995-01-09 Empleo de depsipeptidos ciclicos con 12 atomos en el anillo para la lucha contra endoparasitos, nuevos depsipeptidos ciclicos con 12 atomos en el anillo y procedimiento para su obtencion. Expired - Lifetime ES2115269T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4401389A DE4401389A1 (de) 1994-01-19 1994-01-19 Verwendung von cyclischen Depsipeptiden mit 12 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 12 Ringatomen und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ES2115269T3 true ES2115269T3 (es) 1998-06-16

Family

ID=6508201

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95100198T Expired - Lifetime ES2115269T3 (es) 1994-01-19 1995-01-09 Empleo de depsipeptidos ciclicos con 12 atomos en el anillo para la lucha contra endoparasitos, nuevos depsipeptidos ciclicos con 12 atomos en el anillo y procedimiento para su obtencion.

Country Status (5)

Country Link
US (1) US5663140A (es)
EP (1) EP0664297B1 (es)
JP (1) JP3626233B2 (es)
DE (2) DE4401389A1 (es)
ES (1) ES2115269T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19520275A1 (de) * 1995-06-02 1996-12-05 Bayer Ag Endoparasitizide Mittel
CA2282504A1 (en) * 1997-02-25 1998-08-27 Jun-Ping Xu Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18
DE19713626A1 (de) 1997-04-02 1998-10-08 Bayer Ag Neue Thiodepsipeptide zur Bekämpfung von Endoparasiten und ein einfaches Verfahren zu ihrer Herstellung
DE19962145A1 (de) * 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel/Depsipeptide
DE19962147A1 (de) * 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel / PF 1022-221
DE10031044A1 (de) * 2000-06-26 2002-01-03 Bayer Ag Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere
DE10359798A1 (de) * 2003-12-19 2005-07-21 Bayer Healthcare Ag Cyclohexadepsipeptide zur Bekämpfung von Endoparasiten und ein Verfahren zu ihrer Herstellung
DE102004055316A1 (de) * 2004-11-16 2006-05-18 Bayer Healthcare Ag Verhinderung vertikaler Endoparasiten-Infektionen
DE102008022520A1 (de) * 2008-05-07 2009-11-12 Bayer Animal Health Gmbh Feste Arzneimittelformulierung mit verzögerter Freisetzung
DE102008030764A1 (de) * 2008-06-28 2009-12-31 Bayer Animal Health Gmbh Kombination von Amidin-Derivaten mit cyclischen Depsipeptiden
DE102008031284A1 (de) * 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit der Giardiose
DE102008031283A1 (de) 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit von durch Trichomonadida hervorgerufenen Krankheiten
DE102009012423A1 (de) 2009-03-10 2010-09-16 Bayer Animal Health Gmbh Zubereitung auf Ölbasis
DE102010064245A1 (de) 2010-12-28 2012-06-28 Bayer Animal Health Gmbh Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO176766C (no) * 1989-02-07 1995-05-24 Meiji Seika Kaisha Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
DE4317458A1 (de) * 1992-06-11 1993-12-16 Bayer Ag Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
US5663140A (en) 1997-09-02
DE4401389A1 (de) 1995-07-20
JP3626233B2 (ja) 2005-03-02
DE59501795D1 (de) 1998-05-14
EP0664297A1 (de) 1995-07-26
EP0664297B1 (de) 1998-04-08
JPH07206897A (ja) 1995-08-08

Similar Documents

Publication Publication Date Title
ES2096262T3 (es) Nuevas cyclosporins modificadas en la posicion 1.
ES2114620T3 (es) Composiciones antitumorales que contienen derivados del taxano.
ES2144179T3 (es) Inhibidores de adhesion ciclicos.
PA8442001A1 (es) Derivados de pirimidina biciclica condensada
HN1999000080A (es) Derivados de isotiazol utiles como agentes anticancerosos.
ES2042520T3 (es) Composiciones farmaceuticas que contienen el ester metilico de levodopa, preparacion y aplicaciones terapeuticas del mismo.
GT200000014A (es) Derivados de quinolin - 2 - ona sustituidos con heteroarilo utiles como agentes anticancerigenos.
ATE184598T1 (de) Enniatine und enniatinderivate zur bekämpfung von endoparasiten
ES2187575T3 (es) Hexapeptidos ciclicos dotados de actividad antibiotica.
BR0017026A (pt) Lipeptìdeos como agentes antibacterianos
ECSP055684A (es) Antagonistas del receptor opiode
BR0016467A (pt) Lipopeptìdeos como agentes antibacterianos
ES2181766T3 (es) Analogos de delda 12,13-isotaxol, uso antineoplasico y composiciones farmaceuticas que los contienen.
CO4790174A1 (es) Analogos del peptido lh-rh, sus usos y composiciones farmaceuticas que los contienen
ES2149305T3 (es) Compuestos de dibenzoxazepina sustituidos, composiciones farmaceuticas y procedimientos de uso.
BRPI0017528B8 (pt) uso de uma composição contendo sal de cetotifeno
ES2065929T3 (es) Nuevos derivados de estilbeno, fabricacion y uso de los mismos como medicamentos.
MY199821A (en) Modified lipidated relaxin b chain peptides and their therapeutic use
FR2591485B1 (fr) Compositions stabilisees contenant l'activateur du plasminogene du tissu humain.
AR013079A1 (es) Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios
ES2179996T3 (es) Cefalosporinas de vinil-pirrolidinona con sustituyentes basicos.
ES2115904T3 (es) Derivados amino ramificados del tiazol, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen.
IL169316A (en) Small molecules modulate hepatocyte growth factor (dispersion factor)
ES2106531T3 (es) Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso.
CR7195A (es) Nuevos derivados de oxazolidinonas como antibacterianos

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 664297

Country of ref document: ES