ES2115977T3 - Derivados de antraceno utilizados como agentes anticancerigenos o tintes. - Google Patents

Derivados de antraceno utilizados como agentes anticancerigenos o tintes.

Info

Publication number
ES2115977T3
ES2115977T3 ES94927754T ES94927754T ES2115977T3 ES 2115977 T3 ES2115977 T3 ES 2115977T3 ES 94927754 T ES94927754 T ES 94927754T ES 94927754 T ES94927754 T ES 94927754T ES 2115977 T3 ES2115977 T3 ES 2115977T3
Authority
ES
Spain
Prior art keywords
pct
group
hydrogen
dyes
cancer agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94927754T
Other languages
English (en)
Inventor
David John Mincher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Napier University Ventures Ltd
Edinburgh Napier University
Original Assignee
Napier University Ventures Ltd
Edinburgh Napier University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napier University Ventures Ltd, Edinburgh Napier University filed Critical Napier University Ventures Ltd
Application granted granted Critical
Publication of ES2115977T3 publication Critical patent/ES2115977T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/32—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of condensed quinone ring systems formed by at least three rings
    • C07C225/34—Amino anthraquinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN COMPUESTO CON UNA FORMULA ESTRUCTURAL (I), DONDE R SUP,1} Y R{SUP,2} SON INDEPENDIENTEMENTE HIDROGENO Y OXIHIDRILO, R{SUP,2} Y R{SUP,3} SON INDEPENDIENTEMENTE OXO O HIDROGENO, UNO DE R{SUP,5} Y R{SUP,6} ES A-B Y EL OTRO ES HIDROGENO, OXIHIDRILO, O UN GRUPO A, DONDE CADA A ES INDEPENDIENTEMENTE UN GRUPO ESPACIADOR QUE PROPORCIONA -NH- O -CO- EN EL ENLACE CON B (SI ESTA PRESENTE), LA MENOS UN GRUPO A NO PROPORCIONA EL RESIDUO DE UN ACIDO {AL}-AMINO ADYACENTE AL NUCLEO DE ANTRAQUINONA Y LA A DE CUALQUIER GRUPO A-B SE UNE AL NUCLEO DE ANTRAQUINONA MEDIANTE UN ENLACE -NH-, Y CADA B ES UN GRUPO PEPTIDO; O UN DERIVADO FISIOLOGICAMENTE ACEPTABLE DEL MISMO. LOS COMPUESTOS SON UTILES COMO TINTES O COMPUESTOS ANTI-TUMORALES. LOS COMPUESTOS SON UTILES COMO MEDICAMENTOS ANTI-CANCERIGENOS Y TINTES.
ES94927754T 1993-09-30 1994-09-30 Derivados de antraceno utilizados como agentes anticancerigenos o tintes. Expired - Lifetime ES2115977T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939320191A GB9320191D0 (en) 1993-09-30 1993-09-30 Compounds

Publications (1)

Publication Number Publication Date
ES2115977T3 true ES2115977T3 (es) 1998-07-01

Family

ID=10742784

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94927754T Expired - Lifetime ES2115977T3 (es) 1993-09-30 1994-09-30 Derivados de antraceno utilizados como agentes anticancerigenos o tintes.

Country Status (10)

Country Link
US (1) US5733880A (es)
EP (1) EP0721447B1 (es)
JP (1) JPH09506862A (es)
AT (1) ATE163404T1 (es)
AU (1) AU7705294A (es)
CA (1) CA2172958A1 (es)
DE (1) DE69408683T2 (es)
ES (1) ES2115977T3 (es)
GB (1) GB9320191D0 (es)
WO (1) WO1995009149A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
GB9812937D0 (en) * 1998-06-16 1998-08-12 Btg Int Ltd Compounds
FR2786484B1 (fr) * 1998-11-30 2001-01-05 Oreal Aminoanthraquinones cationiques, leur utilisation pour la teinture des fibres keratiniques, compositions tinctoriales les renfermant et procedes de teinture
GB9903548D0 (en) * 1999-02-16 1999-04-07 Novartis Ag Organic compounds
GB9929801D0 (en) * 1999-12-16 2000-02-09 Btg Int Ltd Anti-cancer agents iii
US6306435B1 (en) 2000-06-26 2001-10-23 Yung Shin Pharmaceutical Industrial Co. Ltd. Oral pharmaceutical preparation embedded in an oily matrix and methods of making the same
US6800615B2 (en) * 2002-04-15 2004-10-05 Board Of Trustees Of Michigan State University Antihelminthic anthraquinones and method of use thereof
US20060099712A1 (en) * 2004-11-08 2006-05-11 Eastman Kodak Company Correlation of anti-cancer activity of dyes with redox potentials
EP1905801A1 (en) * 2006-09-27 2008-04-02 Universität Heidelberg Near infrared fluorophore for the selective labelling of membranes in cells
WO2012138805A2 (en) * 2011-04-04 2012-10-11 Biotium, Inc. Substituted anthraquinone dyes for cellular stains and enzyme detection
US9040567B2 (en) 2011-08-19 2015-05-26 Emory University BAX agonist, compositions, and methods related thereto
US9980936B2 (en) 2014-05-05 2018-05-29 Emory University BH4 antagonists and methods related thereto
KR102100729B1 (ko) * 2018-10-30 2020-04-14 계명대학교 산학협력단 안트라퀴논계 화합물 및 이를 유효성분으로 함유하는 암질환 예방 또는 치료용 조성물
JP2024515964A (ja) * 2021-04-26 2024-04-11 オハイオ ステート イノベーション ファウンデーション 脂質ナノ材料及びその使用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57141456A (en) * 1981-02-27 1982-09-01 Toyo Ink Mfg Co Ltd Pigment composition
US4894451A (en) * 1985-04-01 1990-01-16 The University Of Vermont Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones and derivatives
US4732970A (en) * 1986-06-13 1988-03-22 American Cyanamid Company Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones
US4847359A (en) * 1986-06-30 1989-07-11 Ciba-Geigy Corporation Diamino-9,10-dihydroanthracenes and polyamide acid (esters) and polyimides derived therefrom
US4855084A (en) * 1987-07-01 1989-08-08 Ciba-Geigy Corporation Anthraquinoylcarboxylic acid hydrazides, curable compositions and use thereof
GB8715436D0 (en) * 1987-07-01 1987-08-05 Ciba Geigy Ag Substituted anthraquinones
EP0298031B1 (de) * 1987-07-01 1991-04-10 Ciba-Geigy Ag Substituierte Anthrachinone und härtbare Zusammensetzung
DE4032607A1 (de) * 1990-10-15 1992-05-07 Wella Ag Mittel zum faerben von haaren mit einem gehalt an 1,4-bis((dihydroxyalkyl)amino)-anthrachinon sowie neue 1,4-bis-((dihydroxyalkyl)amino)- anthrachinone
KR920703513A (ko) * 1990-11-02 1992-12-18 클레이턴 아이. 턴칸 단백질 활성효소 c(protein kinase c)를 방해하는 비스-(하이드록시알킬아미노)-안트라퀴논
EP0489220A1 (en) * 1990-12-02 1992-06-10 American Cyanamid Company Cytotoxic N,N'-bis (succinyl-peptide-) derivatives of 1,4-bis (aminoalkyl)-5,8-dihydroxyanthraquinones and antibody conjugates thereof
GB9205859D0 (en) * 1992-03-18 1992-04-29 Imp Cancer Res Tech Compounds

Also Published As

Publication number Publication date
GB9320191D0 (en) 1993-11-17
US5733880A (en) 1998-03-31
EP0721447A1 (en) 1996-07-17
DE69408683D1 (de) 1998-04-02
WO1995009149A1 (en) 1995-04-06
ATE163404T1 (de) 1998-03-15
EP0721447B1 (en) 1998-02-25
CA2172958A1 (en) 1995-04-06
JPH09506862A (ja) 1997-07-08
AU7705294A (en) 1995-04-18
DE69408683T2 (de) 1998-10-01

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