UA27022C2 - Похідhі карбазолоhу як проміжhі сполуки для отримаhhя оhдаhсетроhу - Google Patents

Похідhі карбазолоhу як проміжhі сполуки для отримаhhя оhдаhсетроhу

Info

Publication number
UA27022C2
UA27022C2 UA99052847A UA99052847A UA27022C2 UA 27022 C2 UA27022 C2 UA 27022C2 UA 99052847 A UA99052847 A UA 99052847A UA 99052847 A UA99052847 A UA 99052847A UA 27022 C2 UA27022 C2 UA 27022C2
Authority
UA
Ukraine
Prior art keywords
carbasolon
intermediates
synthesis
derivatives
ondansetron
Prior art date
Application number
UA99052847A
Other languages
English (en)
Russian (ru)
Inventor
Петер БОД
Калман Харшаньі
Ференц ТРІШХЛЕР
Єва ФЕКЕЧ
Аттіла Чехі
Бела Хегедюш
Єва МЕРШІХ
Дьордьі САБО
Еріка Хорват
Original Assignee
Ріхтер Гедеон Ведьєсеті Дьяр Р.Т.
Рихтер Гедеон Ведьесети Дьяр Р.Т.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26318102&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA27022(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from HU9203222A external-priority patent/HU212934B/hu
Priority claimed from HU9203223A external-priority patent/HU212785B/hu
Application filed by Ріхтер Гедеон Ведьєсеті Дьяр Р.Т., Рихтер Гедеон Ведьесети Дьяр Р.Т. filed Critical Ріхтер Гедеон Ведьєсеті Дьяр Р.Т.
Publication of UA27022C2 publication Critical patent/UA27022C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

Винахід належить до галузі медицини, зокрема до лікарських препаратів. В основу винаходу поставлено завдання створення похідних карбазолону як проміжних продуктів для отримання чистого ондансетрону з 100%-ним виходом.
UA99052847A 1992-10-14 1999-05-24 Похідhі карбазолоhу як проміжhі сполуки для отримаhhя оhдаhсетроhу UA27022C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9203222A HU212934B (en) 1992-10-14 1992-10-14 Process for producing novel alkoxalylated carbazolone derivatives
HU9203223A HU212785B (en) 1992-10-14 1992-10-14 Process for producing of a carbazolone derivative

Publications (1)

Publication Number Publication Date
UA27022C2 true UA27022C2 (uk) 2000-02-28

Family

ID=26318102

Family Applications (2)

Application Number Title Priority Date Filing Date
UA93002172A UA26893C2 (uk) 1992-10-14 1993-10-11 Спосіб отримаhhя оhдасетроhу та його фармацевтичhо прийhятhих солей
UA99052847A UA27022C2 (uk) 1992-10-14 1999-05-24 Похідhі карбазолоhу як проміжhі сполуки для отримаhhя оhдаhсетроhу

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UA93002172A UA26893C2 (uk) 1992-10-14 1993-10-11 Спосіб отримаhhя оhдасетроhу та його фармацевтичhо прийhятhих солей

Country Status (20)

Country Link
US (2) US5416221A (uk)
EP (1) EP0595111B2 (uk)
JP (1) JP3378315B2 (uk)
KR (1) KR100289912B1 (uk)
CN (2) CN1052979C (uk)
AT (1) ATE157973T1 (uk)
CA (1) CA2106642C (uk)
CZ (1) CZ284223B6 (uk)
DE (1) DE69313771T3 (uk)
DK (1) DK0595111T4 (uk)
EE (1) EE03071B1 (uk)
ES (1) ES2106936T5 (uk)
GR (1) GR3025599T3 (uk)
HR (1) HRP931292B1 (uk)
PL (2) PL174526B1 (uk)
RO (1) RO115799B1 (uk)
RU (1) RU2119914C1 (uk)
SI (1) SI9300537B (uk)
SK (1) SK281243B6 (uk)
UA (2) UA26893C2 (uk)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226135B1 (en) * 2000-03-28 2008-05-28 Richter Gedeon Nyrt Intermediate of ondansetron and process for its production
KR100368895B1 (ko) * 2000-03-30 2003-01-24 하나제약 주식회사 1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카바졸-4-온의 제조방법
ES2204358T1 (es) * 2000-10-30 2004-05-01 Teva Pharmaceutical Industries Ltd. Nuevas formas de cristal y de disolvente de hidrocloruro de ondasetron y procedimientos para su preparacion.
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
RU2207340C2 (ru) * 2001-08-10 2003-06-27 Ципла Лтд. Способ получения 1,2,3,9-тетрагидро-9-метил-3-[(2-метил-1н-имидазол-1-ил)метил]-4н-карбазол -4-она или его фармацевтически приемлемых солей
MXPA04010846A (es) * 2002-04-29 2005-01-25 Biogal Gyogyszergyar Proceso para preparar 1, 2, 3, 9-tetrahidro -9- metil-3 -[(2-metil -1h-imidazol -1-il) metil]- 4h- carbazol -4- ona.
US20040019093A1 (en) * 2002-04-30 2004-01-29 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
EP1654228B1 (en) * 2003-06-10 2008-10-22 Smithkline Beecham Corporation Tetrahydrocarbazole derivatives and their pharmaceutical use
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
WO2006025069A2 (en) * 2004-07-12 2006-03-09 Cadila Healthcare Limited Tricyclic pyrazole derivatives as cannabinoid receptor modulators
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
US7547791B2 (en) * 2004-10-26 2009-06-16 Ipca Laboratories Ltd. One-pot process for the preparation of antiemetic agent, 1,2,3,9-tetrahydro-9-methyl-3[(2-methyl)-1H-imidazole-1-yl)methyl]-4H-carbazol-4-O
ES2369782T3 (es) * 2004-12-27 2011-12-05 Actelion Pharmaceuticals Ltd. Derivados de 2,3,4,9-tetrahidro-1h-carbazol como antagonistas del receptor crth2.
CN115677561B (zh) * 2022-11-01 2024-04-05 常州兰陵制药有限公司 一种1,2,3,4-四氢-9-甲基-4h-咔唑酮及其合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
HU193592B (en) * 1984-01-25 1987-11-30 Glaxo Group Ltd Process for producing tetrahydro-carbazolone derivatives
CN1011237B (zh) * 1984-01-25 1991-01-16 格拉克索公司 1，2，3，9-四氢-3-[(2-甲基-1h-咪唑-1-基)甲基]-4h-咔唑-4-酮类和其盐以及溶剂化物的制备
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
GB8628473D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Chemical compounds
JPH01258673A (ja) * 1987-10-22 1989-10-16 Glaxo Group Ltd ケトン誘導体

Also Published As

Publication number Publication date
US5478949A (en) 1995-12-26
PL300685A1 (en) 1994-04-18
US5416221A (en) 1995-05-16
CN1083430C (zh) 2002-04-24
EP0595111B1 (en) 1997-09-10
EP0595111B2 (en) 2001-08-16
PL174526B1 (pl) 1998-08-31
SK111093A3 (en) 1994-11-09
GR3025599T3 (en) 1998-03-31
CZ215693A3 (en) 1994-05-18
HRP931292B1 (en) 1999-08-31
DK0595111T4 (da) 2001-10-22
DK0595111T3 (da) 1998-04-14
SI9300537A (en) 1994-06-30
SI9300537B (sl) 2003-02-28
PL174173B1 (pl) 1998-06-30
CA2106642A1 (en) 1994-04-15
CN1089941A (zh) 1994-07-27
EE03071B1 (et) 1998-02-16
KR100289912B1 (ko) 2001-09-17
RU2119914C1 (ru) 1998-10-10
EP0595111A1 (en) 1994-05-04
DE69313771D1 (de) 1997-10-16
JP3378315B2 (ja) 2003-02-17
ES2106936T3 (es) 1997-11-16
ES2106936T5 (es) 2001-12-16
JPH06293734A (ja) 1994-10-21
SK281243B6 (sk) 2001-01-18
RO115799B1 (ro) 2000-06-30
DE69313771T2 (de) 1998-02-12
CA2106642C (en) 2005-08-16
UA26893C2 (uk) 1999-12-29
CZ284223B6 (cs) 1998-09-16
DE69313771T3 (de) 2002-04-18
KR940009152A (ko) 1994-05-20
CN1052979C (zh) 2000-05-31
HRP931292A2 (en) 1994-12-31
CN1235967A (zh) 1999-11-24
ATE157973T1 (de) 1997-09-15

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