ES2118575T3 - 2-heteroaril-5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepinas y su uso en la prevencion o tratamiento de la infeccion con hiv. - Google Patents

2-heteroaril-5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepinas y su uso en la prevencion o tratamiento de la infeccion con hiv.

Info

Publication number
ES2118575T3
ES2118575T3 ES95910286T ES95910286T ES2118575T3 ES 2118575 T3 ES2118575 T3 ES 2118575T3 ES 95910286 T ES95910286 T ES 95910286T ES 95910286 T ES95910286 T ES 95910286T ES 2118575 T3 ES2118575 T3 ES 2118575T3
Authority
ES
Spain
Prior art keywords
diazepines
prevention
treatment
hiv
dipirido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95910286T
Other languages
English (en)
Inventor
Karl D Hargrave
Terence A Kelly
Suresh R Kapadia
John R Proudfoot
Daniel W Mcneil
Usha R Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2118575T3 publication Critical patent/ES2118575T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SON DESCUBIERTOS NUEVAS 2-HETEROARIL-5,11-DIHIDRO-6HDIPIRIDO[3,2-B:2`,3`][1,4]DIAZEPINAS DE FORMULA (I) EN DONDE Z ES UN ATOMO OXIGENO O AZUFRE, =NCN O UN GRUPO DE LA FORMULA =NOR{SUP,1O} EN DONDE R{SUP,10} ES ALQUILO DE 1 A 3 ATOMOS DE CARBONO, AR ES UN GRUPO DE FORMULAS (I,II,III,IV O V). ESTOS COMPUESTOS SON UTILES EN LA PREVENCION O EL TRATAMIENTO DE LAS INFECCIONES DE VIH.
ES95910286T 1994-02-18 1995-02-17 2-heteroaril-5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepinas y su uso en la prevencion o tratamiento de la infeccion con hiv. Expired - Lifetime ES2118575T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19824294A 1994-02-18 1994-02-18
US35641594A 1994-12-14 1994-12-14

Publications (1)

Publication Number Publication Date
ES2118575T3 true ES2118575T3 (es) 1998-09-16

Family

ID=26893601

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95910286T Expired - Lifetime ES2118575T3 (es) 1994-02-18 1995-02-17 2-heteroaril-5,11-dihidro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepinas y su uso en la prevencion o tratamiento de la infeccion con hiv.

Country Status (15)

Country Link
EP (1) EP0745083B1 (es)
JP (1) JPH09509179A (es)
KR (1) KR970701190A (es)
CN (1) CN1043347C (es)
AT (1) ATE166353T1 (es)
AU (1) AU690646B2 (es)
CA (1) CA2183571A1 (es)
CO (1) CO4340691A1 (es)
DE (1) DE69502587T2 (es)
DK (1) DK0745083T3 (es)
ES (1) ES2118575T3 (es)
PL (1) PL181323B1 (es)
RU (1) RU2142464C1 (es)
TW (1) TW327171B (es)
WO (1) WO1995022545A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705499A (en) * 1995-10-06 1998-01-06 Boehringer Ingelheim Pharmaceuticals, Inc. 8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection
US5747488A (en) * 1996-01-30 1998-05-05 Boehringer Ingelheim Pharmaceuticals, Inc. 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
EP1019394A1 (en) 1997-05-22 2000-07-19 G.D. Searle & Co. PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
US6716836B2 (en) * 2001-03-22 2004-04-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
AU2005233642A1 (en) * 2004-04-13 2005-10-27 Astellas Pharma Inc. Polycyclic pyridines as potassium ion channel modulators
KR20070034049A (ko) 2004-06-09 2007-03-27 글락소 그룹 리미티드 피롤로피리딘 유도체
WO2007059219A1 (en) 2005-11-15 2007-05-24 Vertex Pharmaceuticals Incorporated Azaindazoles useful as inhibitors of kinases
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
JP2016503395A (ja) 2012-10-31 2016-02-04 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 病害生物防除剤としての複素環化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3122670A1 (de) * 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
EP0410148B1 (en) * 1989-06-28 1994-04-06 Boehringer Ingelheim Pharmaceuticals Inc. Novel 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones and thiones and their use in the prevention or treatment of AIDS
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
DK0498290T3 (es) * 1991-02-07 1997-02-10 Boehringer Ingelheim Pharma

Also Published As

Publication number Publication date
RU2142464C1 (ru) 1999-12-10
CO4340691A1 (es) 1996-07-30
WO1995022545A1 (en) 1995-08-24
ATE166353T1 (de) 1998-06-15
KR970701190A (ko) 1997-03-17
CN1043347C (zh) 1999-05-12
MX9603359A (es) 1998-07-31
JPH09509179A (ja) 1997-09-16
PL181323B1 (pl) 2001-07-31
DE69502587T2 (de) 1998-11-26
AU1845795A (en) 1995-09-04
CN1138861A (zh) 1996-12-25
CA2183571A1 (en) 1995-08-24
PL316006A1 (en) 1996-12-23
AU690646B2 (en) 1998-04-30
EP0745083B1 (en) 1998-05-20
DE69502587D1 (de) 1998-06-25
TW327171B (en) 1998-02-21
EP0745083A1 (en) 1996-12-04
DK0745083T3 (da) 1999-01-25

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