ES2119190T3 - Procedimiento para producir un compuesto de lignano. - Google Patents

Procedimiento para producir un compuesto de lignano.

Info

Publication number
ES2119190T3
ES2119190T3 ES94912092T ES94912092T ES2119190T3 ES 2119190 T3 ES2119190 T3 ES 2119190T3 ES 94912092 T ES94912092 T ES 94912092T ES 94912092 T ES94912092 T ES 94912092T ES 2119190 T3 ES2119190 T3 ES 2119190T3
Authority
ES
Spain
Prior art keywords
compound
general formula
producing
lower alkyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94912092T
Other languages
English (en)
Inventor
Sachio Mori
Shozo Takechi
Shiro Kida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2119190T3 publication Critical patent/ES2119190T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

UN PROCESO PARA PRODUCIR REGIOSELECTIVAMENTE UN COMPUESTO DE LIGANDO DE FORMULA GENERAL (I) REACCIONADO UN COMPUESTO DE LACTONA DE FORMULA GENERAL (II) CON UN COMPUESTO DE LA FORMULA R7CL (SIENDO R7 UN GRUPO TRI(ALQUILO INFERIOR)SILILO) EN PRESENCIA DE UNA BASE, EFECTUANDO LA REACCION DE ADICION DE UN COMPUESTO DE ACETILENO DE FORMULA GENERAL (II) CON EL COMPUESTO RESULTANTE, Y REDUCIENDO EL PRODUCTO. EN DICHAS FORMULAS R1 REPRESENTA ALQUILO, CICLOALQUILO, CICLOALQUIL-ALQUILO INFERIOR, ARALQUILO, ETC.: R2 Y R3 CADA UNO REPRESENTA ALCOXI INFERIOR, ETC.; R4 REPRESENTA ALCOXI INFERIOR O HIDROGENO; Y R5 Y R6 REPRESENTAN CADA UNO ALQUILO INFERIOR.
ES94912092T 1993-04-16 1994-04-12 Procedimiento para producir un compuesto de lignano. Expired - Lifetime ES2119190T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8994493 1993-04-16

Publications (1)

Publication Number Publication Date
ES2119190T3 true ES2119190T3 (es) 1998-10-01

Family

ID=13984820

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94912092T Expired - Lifetime ES2119190T3 (es) 1993-04-16 1994-04-12 Procedimiento para producir un compuesto de lignano.

Country Status (13)

Country Link
US (1) US5488134A (es)
EP (1) EP0646570B1 (es)
JP (1) JP3411036B2 (es)
KR (1) KR100277242B1 (es)
CN (1) CN1046937C (es)
AT (1) ATE167662T1 (es)
AU (1) AU666819B2 (es)
CA (1) CA2138264C (es)
DE (1) DE69411243T2 (es)
DK (1) DK0646570T3 (es)
ES (1) ES2119190T3 (es)
TW (1) TW255886B (es)
WO (1) WO1994024087A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
KR100376281B1 (ko) * 1995-12-26 2003-09-26 에스케이케미칼주식회사 리그난의 제조방법
DK1026167T3 (da) 1997-09-29 2003-05-26 Meiji Seika Kaisha Tricykliske triazolobenzazepinderivater, fremgangsmåde til fremstilling af disse samt antiallergiske midler
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
DK1140189T3 (da) 1998-12-23 2003-09-15 Searle Llc Kombinationer af ileal galdesyre-transportinhibitorer og fibrinsyrederivater til cardiovaskulære indikationer
AU3103800A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications
AU2157500A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
BR9916486A (pt) 1998-12-23 2002-02-05 Searle Llc Combinações de inibidores do transporte de ácidos biliares no ìleo e inibidores da proteìna de transferência do ester colesteril para indicações cardiovasculares
EA004877B1 (ru) 1998-12-23 2004-08-26 Джи.Ди.Сирл Ллс Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и агентов, секвестрирующих желчные кислоты, для сердечно-сосудистых показаний
US6458850B1 (en) 1998-12-23 2002-10-01 G.D. Searle, Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
EP1286984A2 (en) 2000-03-10 2003-03-05 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
WO2001068096A2 (en) * 2000-03-10 2001-09-20 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
BR0213501A (pt) 2001-11-02 2004-08-24 Searle Llc Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato
MXPA04006255A (es) 2002-01-17 2004-09-27 Pharmacia Corp Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato.
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
EP4137137A1 (en) 2010-05-26 2023-02-22 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
JP6217938B2 (ja) 2011-10-28 2017-10-25 ルメナ ファーマシューティカルズ エルエルシー 小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤
EA038594B1 (ru) 2011-10-28 2021-09-21 Шайр Хьюман Дженетик Терапис, Инк. Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени
KR20160002773A (ko) 2013-03-15 2016-01-08 루메나 파마수티컬즈, 인코포레이티드 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제
AU2014229050A1 (en) 2013-03-15 2015-10-22 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease
EP4424363B1 (en) 2019-02-12 2026-04-29 Mirum Pharmaceuticals, Inc. Methods for increasing growth in pediatric subjects having cholestatic liver disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0372422A (ja) * 1989-05-16 1991-03-27 Tanabe Seiyaku Co Ltd 抗脂血剤
JPH03157351A (ja) * 1989-11-13 1991-07-05 Tanabe Seiyaku Co Ltd ナフタレン誘導体及びその製法
ATE139990T1 (de) * 1991-10-17 1996-07-15 Shionogi & Co Lignan-analoge, ihre herstellung und hypolipidemische arzneimittel

Also Published As

Publication number Publication date
CN1046937C (zh) 1999-12-01
CA2138264A1 (en) 1994-10-27
CA2138264C (en) 2004-04-06
KR950701902A (ko) 1995-05-17
CN1109685A (zh) 1995-10-04
EP0646570A1 (en) 1995-04-05
JP3411036B2 (ja) 2003-05-26
WO1994024087A1 (fr) 1994-10-27
DK0646570T3 (da) 1998-10-26
AU666819B2 (en) 1996-02-22
TW255886B (es) 1995-09-01
AU6437994A (en) 1994-11-08
ATE167662T1 (de) 1998-07-15
DE69411243T2 (de) 1998-11-19
EP0646570B1 (en) 1998-06-24
EP0646570A4 (en) 1995-08-09
KR100277242B1 (ko) 2001-02-01
DE69411243D1 (de) 1998-07-30
US5488134A (en) 1996-01-30

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