ES2120647T3 - Procedimiento para la preparacion de compuestos de carbapenem. - Google Patents

Procedimiento para la preparacion de compuestos de carbapenem.

Info

Publication number
ES2120647T3
ES2120647T3 ES95104559T ES95104559T ES2120647T3 ES 2120647 T3 ES2120647 T3 ES 2120647T3 ES 95104559 T ES95104559 T ES 95104559T ES 95104559 T ES95104559 T ES 95104559T ES 2120647 T3 ES2120647 T3 ES 2120647T3
Authority
ES
Spain
Prior art keywords
sub
compound
substituted
iii
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95104559T
Other languages
English (en)
Inventor
Makoto Sunagawa
Haruki Matsumura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of ES2120647T3 publication Critical patent/ES2120647T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NUEVO Y EFECTIVO PROCESO PARA PREPARAR UN COMPUESTO DE CARBAPENEMO DE LA FORMULA (III): DONDE R{SUB,1} Y R{SUB,2} SON CADA UNO H O ALKILO BAJO, R{SUB,3} ES ALKILO BAJO, R{SUB,4} ES UN GRUPO DE PROTECCION, L ES ARILSULFONILOXI SUSTITUIDO O NO SUSTITUIDO, ALCANESULFONILOXI BAJO, ALCANESULFONILOXI DE HALOGENO BAJO, DI-ALKILFOSFORILOXI BAJO, ETC., Y X ES H O HIDROXI PROTEGIDO, EL CUAL COMPRENDE UN COMPUESTO {BE}LACTAMA DE REACCION (I) CON UN DERIVADO ESTER DE ACIDO ACETICO (II), EN LA PRESENCIA DE BASE, SEGUIDO DEL TRATAMIENTO DEL PRODUCTO CON UN AGENTE ESTERIFICANTE ACTIVO PARA UN GRUPO HIDROXI, DICHO COMPUESTO (III) SIENDO UTIL COMO INTERMEDIARIO PARA UN COMPUESTO 1{BE}A-ALKILCARBAPENEMO QUE TIENE ACTIVIDAD ANTIBACTERIANA.
ES95104559T 1994-03-29 1995-03-28 Procedimiento para la preparacion de compuestos de carbapenem. Expired - Lifetime ES2120647T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8392894 1994-03-29

Publications (1)

Publication Number Publication Date
ES2120647T3 true ES2120647T3 (es) 1998-11-01

Family

ID=13816267

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95104559T Expired - Lifetime ES2120647T3 (es) 1994-03-29 1995-03-28 Procedimiento para la preparacion de compuestos de carbapenem.

Country Status (5)

Country Link
US (1) US5578722A (es)
EP (1) EP0679652B1 (es)
CA (1) CA2145800A1 (es)
DE (1) DE69504125T2 (es)
ES (1) ES2120647T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0977567A4 (en) * 1996-09-13 2000-02-09 Merck & Co Inc Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
JPWO2004043961A1 (ja) * 2002-11-13 2006-03-09 株式会社カネカ 経口投与用カルバペネム化合物の製造方法
DK2326648T3 (da) * 2008-07-30 2012-10-15 Ranbaxy Lab Ltd Fremgangsmåde til fremstillingen af carbapenemforbindelser
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
CN103012471A (zh) * 2012-12-17 2013-04-03 凯莱英医药集团（天津）股份有限公司 一种制备β-甲基碳青霉素烯类抗生素关键中间体的方法
WO2017132321A1 (en) 2016-01-29 2017-08-03 The Johns Hopkins University Novel inhibitors of bacterial growth
CN107098371A (zh) * 2016-02-23 2017-08-29 达州励志环保科技有限公司 一种利用氟化铝生产废水制备钾冰晶石的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
US5310897A (en) * 1984-12-27 1994-05-10 Sumitomo Pharmaceuticals Co., Ltd. Beta-lactams and their production
NZ214691A (en) * 1984-12-27 1988-08-30 Sumitomo Pharma The preparation of carbapenem derivatives and beta-lactam intermediates

Also Published As

Publication number Publication date
US5578722A (en) 1996-11-26
CA2145800A1 (en) 1995-09-30
DE69504125T2 (de) 1999-04-22
EP0679652A1 (en) 1995-11-02
DE69504125D1 (de) 1998-09-24
EP0679652B1 (en) 1998-08-19

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