ES2120964T3 - Peptidos osteogenicos. - Google Patents

Peptidos osteogenicos.

Info

Publication number
ES2120964T3
ES2120964T3 ES91919612T ES91919612T ES2120964T3 ES 2120964 T3 ES2120964 T3 ES 2120964T3 ES 91919612 T ES91919612 T ES 91919612T ES 91919612 T ES91919612 T ES 91919612T ES 2120964 T3 ES2120964 T3 ES 2120964T3
Authority
ES
Spain
Prior art keywords
osteogenic
methods
proteins
polypeptide chains
osteogenic devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91919612T
Other languages
English (en)
Inventor
Hermann Oppermann
Engin Ozkaynak
David C Reuger
Thangavel Kuberasampath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stryker Corp filed Critical Stryker Corp
Application granted granted Critical
Publication of ES2120964T3 publication Critical patent/ES2120964T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE 1) EL CDNA Y SECUENCIAS DE ACIDO AMINO PARA NUEVAS CADENAS DE POLIPEPTIDO UTILES COMO SUBUNIDADES DE PROTEINAS OSTEOGENICAS DIMERICAS, 2) DISPOSITIVOS OSTEOGENICOS QUE COMPRENDEN ESTAS PROTEINAS EN ASOCIACION CON UNA MATRIZ PORTADORA APROPIADA, 3) METODOS DE PRODUCIR LAS CADENAS POLIPEPTIDAS EMPLEANDO TECNOLOGIA DE DNA RECOMBINANTE, Y 4) METODOS PARA USAR LOS DISPOSITIVOS OSTEOGENICOS PARA IMITAR EL CURSO NATURAL DE LA FORMACION OSEA ENDOCONDRAL EN MAMIFEROS.
ES91919612T 1990-10-18 1991-10-18 Peptidos osteogenicos. Expired - Lifetime ES2120964T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59954390A 1990-10-18 1990-10-18

Publications (1)

Publication Number Publication Date
ES2120964T3 true ES2120964T3 (es) 1998-11-16

Family

ID=24400058

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91919612T Expired - Lifetime ES2120964T3 (es) 1990-10-18 1991-10-18 Peptidos osteogenicos.

Country Status (9)

Country Link
EP (1) EP0643767B1 (es)
JP (2) JPH07500487A (es)
AT (1) ATE168719T1 (es)
AU (1) AU663689B2 (es)
CA (1) CA2094027C (es)
DE (1) DE69129865T2 (es)
DK (1) DK0643767T3 (es)
ES (1) ES2120964T3 (es)
WO (1) WO1992007073A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US7378392B1 (en) 1990-05-16 2008-05-27 Genetics Institute, Llc Bone and cartilage inductive proteins
JPH06500991A (ja) * 1990-05-16 1994-01-27 ジェネティックス・インスティテュート・インコーポレイテッド 骨および軟骨誘導蛋白質
US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5739107A (en) 1991-03-11 1998-04-14 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US6395883B1 (en) 1991-03-11 2002-05-28 Curis, Inc. Soluble morphogenic protein complex compositions of matter
US6194376B1 (en) 1991-03-11 2001-02-27 Creative Biomolecules, Inc. Method for modulating inflammatory response comprising administering morphogen
AU652472B2 (en) * 1991-06-25 1994-08-25 Genetics Institute, Llc BMP-9 compositions
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
ATE192931T1 (de) * 1991-08-30 2000-06-15 Creative Biomolecules Inc Morphogen-induzierte modulation von entzündlichen antworten
ATE287949T1 (de) * 1992-07-31 2005-02-15 Stryker Corp Löslicher komplex morphogener proteine und zusammensetzungen davon
JP3645258B2 (ja) * 1993-01-12 2005-05-11 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−５
EP0717633A4 (en) * 1993-07-09 1998-05-20 Univ Johns Hopkins Med GROWTH DIFFERENTIATION FACTOR-7
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
DE69434651T2 (de) 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
EP0845006A2 (en) * 1995-08-14 1998-06-03 Creative Biomolecules, Inc. Binding of osteogenic protein-i (op-1) and analogs thereof to the cell surface receptor alk-1 and analogs thereof
JP2000501744A (ja) * 1996-01-22 2000-02-15 クリエイティブ バイオモレキゥルズ，インコーポレーテッド モルホゲン類似体およびその製法
KR20000064752A (ko) 1996-03-22 2000-11-06 더 제네랄 호스피탈 코포레이션 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
PT1223990E (pt) 1999-10-15 2004-12-31 Fidia Advanced Biopolymers Srl Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
EP1266961A4 (en) * 2000-03-16 2004-12-08 Kyowa Hakko Kogyo Kk LIVER HEALING FACTOR
EP1399023B1 (en) 2001-06-01 2008-04-30 Wyeth COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENETIC PROTEINS& x9;
ATE303169T1 (de) 2001-11-19 2005-09-15 Scil Technology Gmbh Homogen beschichtete vorrichtung mit osteoinduktiven und osteokonduktiven eigenschaften
AU2003253049A1 (en) 2002-09-10 2004-04-30 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
US8372419B2 (en) 2004-03-10 2013-02-12 Scil Technology Gmbh Coated implants, their manufacturing and use thereof
EP3147296A1 (en) * 2005-11-14 2017-03-29 Merial, Inc. Gene therapy for renal failure
WO2023272658A1 (zh) * 2021-06-30 2023-01-05 北京泽勤生物医药有限公司 增强成骨细胞活性的多肽及其在治疗骨科疾病中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2522568B2 (ja) * 1988-04-08 1996-08-07 ストライカー・コーポレーション 骨形成デバイス
DE69031939T2 (de) * 1989-03-28 1998-09-10 Genetics Institute, Inc., Cambridge, Mass. Osteoinduktive zusammensetzungen

Also Published As

Publication number Publication date
CA2094027A1 (en) 1992-04-19
EP0643767B1 (en) 1998-07-22
DK0643767T3 (da) 1999-04-26
CA2094027C (en) 2001-12-25
JPH07500487A (ja) 1995-01-19
WO1992007073A1 (en) 1992-04-30
DE69129865D1 (de) 1998-08-27
EP0643767A1 (en) 1995-03-22
DE69129865T2 (de) 1999-03-04
JPH11262395A (ja) 1999-09-28
AU663689B2 (en) 1995-10-19
AU8900091A (en) 1992-05-20
ATE168719T1 (de) 1998-08-15

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