ES2121993T3 - Derivados de 4-oxo-2-tioxoimidazolidina como sustancias inhibidoras de la agregacion de plaquetas sanguineas. - Google Patents

Derivados de 4-oxo-2-tioxoimidazolidina como sustancias inhibidoras de la agregacion de plaquetas sanguineas.

Info

Publication number
ES2121993T3
ES2121993T3 ES93904010T ES93904010T ES2121993T3 ES 2121993 T3 ES2121993 T3 ES 2121993T3 ES 93904010 T ES93904010 T ES 93904010T ES 93904010 T ES93904010 T ES 93904010T ES 2121993 T3 ES2121993 T3 ES 2121993T3
Authority
ES
Spain
Prior art keywords
thioxoimidazolidine
derivatives
oxo
inhibiting substances
blood plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93904010T
Other languages
English (en)
Inventor
Gerhard Zoller
Bernd Jablonka
Jochen Knolle
Melitta Just
Wolfgang Konig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2121993T3 publication Critical patent/ES2121993T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • External Artificial Organs (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A DERIVADOS 4 TIOXOIMIDAZOLIDINA DE LA FORMULA GENERAL (I), DONDE R1 HASTA R4, ASI COMO Y, ESTAN DEFINIDOS COMO EN LA DESCRIPCION, PROCESO PARA SU ELABORACION Y SU UTILIZACION COMO SUSTANCIAS INHIBIDORAS DE AGREGACION DE TROMBOCITOS DE LA METASTASIS DE CELULAS DE CARCINOMA ASI COMO LA FORMACION DE OSTEOCLASTAS EN LA SUPERFICIE DE LOS HUESOS.
ES93904010T 1992-03-07 1993-02-24 Derivados de 4-oxo-2-tioxoimidazolidina como sustancias inhibidoras de la agregacion de plaquetas sanguineas. Expired - Lifetime ES2121993T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4207254A DE4207254A1 (de) 1992-03-07 1992-03-07 4-oxo-2-thioxoimidazolidin-derivate

Publications (1)

Publication Number Publication Date
ES2121993T3 true ES2121993T3 (es) 1998-12-16

Family

ID=6453475

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93904010T Expired - Lifetime ES2121993T3 (es) 1992-03-07 1993-02-24 Derivados de 4-oxo-2-tioxoimidazolidina como sustancias inhibidoras de la agregacion de plaquetas sanguineas.

Country Status (16)

Country Link
EP (1) EP0629211B1 (es)
JP (1) JP3495369B2 (es)
KR (1) KR100278532B1 (es)
AT (1) ATE169634T1 (es)
AU (1) AU665617B2 (es)
CA (1) CA2130174C (es)
CZ (1) CZ286327B6 (es)
DE (2) DE4207254A1 (es)
DK (1) DK0629211T3 (es)
ES (1) ES2121993T3 (es)
HU (1) HU217430B (es)
IL (1) IL104960A (es)
SK (1) SK281822B6 (es)
TW (1) TW255888B (es)
WO (1) WO1993018057A1 (es)
ZA (1) ZA931537B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228717A1 (de) * 1992-08-28 1994-03-03 Cassella Ag Imidazolidin-Derivate
DE4427979A1 (de) * 1993-11-15 1996-02-15 Cassella Ag Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
US5599829A (en) * 1995-11-28 1997-02-04 American Home Products Corporation 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives for increasing HDL cholesterol levels
US5821372A (en) * 1995-11-28 1998-10-13 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
TW418195B (en) * 1995-11-28 2001-01-11 American Home Prod 2-thioxo-imidazolidin-4-one derivatives
US5554607A (en) * 1995-11-28 1996-09-10 American Home Products Corporation Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of atherosclerosis
ATE212990T1 (de) 1996-03-20 2002-02-15 Hoechst Ag Inhibitoren der knochenresorption und vitronectinrezeptor-antagonisten
ZA972381B (en) * 1996-03-20 1998-12-21 Hoechst Ag Novel inhibitors of bone reabsorption and antagonists of vitronectin receptors
DE19629817A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19629816A1 (de) 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
US5861517A (en) * 1996-11-21 1999-01-19 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
US5663363A (en) * 1996-11-21 1997-09-02 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19922462A1 (de) 1999-05-17 2000-11-23 Aventis Pharma Gmbh Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10111877A1 (de) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
TWI339093B (en) 2007-08-24 2011-03-11 Asustek Comp Inc Cellular phone with shiftless motion function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970225A (en) 1990-02-13 1990-11-13 Bristol-Myers Squibb Company Imidazolidine carboxylic acids and esters as blood platelet aggregation inhibitors
DE4009506A1 (de) * 1990-03-24 1991-09-26 Hoechst Ag Hydantoinderivate

Also Published As

Publication number Publication date
HUT69716A (en) 1995-09-28
WO1993018057A1 (de) 1993-09-16
EP0629211B1 (de) 1998-08-12
EP0629211A1 (de) 1994-12-21
IL104960A (en) 1996-12-05
CZ216694A3 (en) 1995-04-12
TW255888B (es) 1995-09-01
CA2130174A1 (en) 1993-09-16
ATE169634T1 (de) 1998-08-15
DE4207254A1 (de) 1993-09-09
DE59308872D1 (de) 1998-09-17
KR950700321A (ko) 1995-01-16
JP3495369B2 (ja) 2004-02-09
AU665617B2 (en) 1996-01-11
AU3498893A (en) 1993-10-05
HU217430B (hu) 2000-01-28
CA2130174C (en) 2003-09-09
KR100278532B1 (ko) 2001-01-15
SK107294A3 (en) 1995-04-12
CZ286327B6 (cs) 2000-03-15
SK281822B6 (sk) 2001-08-06
HU9402564D0 (en) 1994-11-28
ZA931537B (en) 1993-09-27
IL104960A0 (en) 1993-07-08
JPH07506567A (ja) 1995-07-20
DK0629211T3 (da) 1999-05-17

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