ES2123149T3 - PERHYDROISOINDOL DERIVATIVES AS ANTAGONISTS OF THE SUBSTANCE P. - Google Patents

PERHYDROISOINDOL DERIVATIVES AS ANTAGONISTS OF THE SUBSTANCE P.

Info

Publication number
ES2123149T3
ES2123149T3 ES94923755T ES94923755T ES2123149T3 ES 2123149 T3 ES2123149 T3 ES 2123149T3 ES 94923755 T ES94923755 T ES 94923755T ES 94923755 T ES94923755 T ES 94923755T ES 2123149 T3 ES2123149 T3 ES 2123149T3
Authority
ES
Spain
Prior art keywords
sub
alcoil
perhydroisoindol
antagonists
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94923755T
Other languages
Spanish (es)
Inventor
Daniel Achard
Serge Grisoni
Evelyne James-Surcouf
Jean-Luc Malleron
Anne Morgat
Jean-Francois Peyronel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9309400A external-priority patent/FR2709752B1/en
Priority claimed from FR9311946A external-priority patent/FR2710913B1/en
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2123149T3 publication Critical patent/ES2123149T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NUEVOS DERIVADOS DE PERHIDROISOINDOL DE FORMULA GENERAL (I) EN LA QUE R{SUB,1} ES FENILO EVENTUALMENTE SUTITUIDO, CICLOHEXADIENILO, NAFTILO, INDENILO O HETEROCICLILO QUE PUEDE SER SUSTITUIDO, R{SUB,2} ES H, HALOGENO, OH, ALCOILO, AMINOALCOILO, ALCOILAMINOALCOILO, DIALCOILAMINOALCOILO, ALCOILOCI, ALCOILTIO, ACILOXI, CARBOXI, ALCOILOXICARBONILO EVENTUALMENTE SUSTITUIDO, BENCILOXICARBONILO, DIALCOILAMINOALCOILO, R{SUB,3} ES UN RADICAL FENILO, EVENTUALMENTE SUSTITUIDO EN POSICION (2) POR ALCOILO O ALCOILOXI (1 0 2C) O POR UN ATOMO DE FLUOR, O DISTRIBUIDO POR TRIFLUORMETILO Y R{SUB,5} Y R''{SUB,5} SON IDENTICO O DIFERENTES Y REPRESENTAN UNO H U OH O ALCOILO Y EL OTRO H O ALCOILO, Y R{SUB,4} ES OH, O BIEN R{SUB,4} ES OH, O BIEN R{SUB,4} ES F SI LOS SIMBOLOS R{SUB,5} Y R''{SUB,5 SON H O ALCOILO, O BIEN R{SUB,4} FORMA CON R{SUB,5} UN ENLACE , Y R{SUB,6} ES H O ALCOILO, HIDROI O HIDROXIALCOILO, Y LOS SIMBOLOS R SON UNO H, ALCOILO, HIDROXI O HIDROXIALCOILO Y EL OTRO H, ALCOILO, FENILO O HIDROXIALCOILO,BAJOS SUS FORMAS ISOMERAS DE ESTRUCTURA (IA) O SUS MEZCLAS, EVENTUALMENTE SUS SALES CUANDO EXISTEN Y SUPREPARACION. LOS NUEVOS DERIVADOS SEGUN LA INVENCION SON PARTICULARMENTE INTERESANTERS COMO ANTAGONISTAS DE LA SUSTANCIA P.NEW DERIVATIVES OF PERHYDROISOINDOL FROM GENERAL FORMULA (I) IN WHICH R {SUB, 1} IS EVENTUALLY SUBSTITUTED PHENYL, CYCLLOHEXADIENYL, NAPHYTHL, INDENYL OR HETEROCICLYL THAT MAY BE REPLACED, R {SUB, 2} IS H, HALOGEN ,, AMINOALCOILO, ALCOILAMINOALCOILO, DIALCOILAMINOALCOILO, ALCOILOCI, ALCOILTIO, ACILOXI, CARBOXI, EVENTUALLY SUBSTITUTED, BENCILOXICARBONILO, DIALCOILAMINOALCOILO, DIALCOILAMINOALCOIL OR BY AN ATOM OF FLUORIDE, OR DISTRIBUTED BY TRIFLUORMETHYL YR {SUB, 5} AND R '' {SUB, 5} ARE IDENTIFIC OR DIFFERENT AND REPRESENT ONE HU OH OR ALCOIL AND THE OTHER HO ALCOIL, YR {SUB, 4} IS OH, OR R {SUB, 4} IS OH, OR R {SUB, 4} IS F IF THE SYMBOLS R {SUB, 5} AND R '' {SUB, 5 ARE HO ALCOIL, OR R {SUB, 4} FORM WITH R {SUB, 5} A LINK, YR {SUB, 6} IS HO ALCOIL, HIDROI OR HYDROXIALCOYL, AND THE SYMBOLS R ARE ONE H, ALCOIL, HYDROXYL OR HYDROXIALCOYL AND THE OTHER H, ALCOIL, PHENYL OR HYDROX LCOILO, UNDER ITS ISOMEROUS FORMS OF STRUCTURE (IA) OR ITS MIXTURES, EVENTUALLY ITS SALTS WHEN THERE ARE AND SUPREPARATION. THE NEW DERIVATIVES ACCORDING TO THE INVENTION ARE PARTICULARLY INTERESTING AS ANTAGONISTS OF THE SUBSTANCE P.

ES94923755T 1993-07-30 1994-07-28 PERHYDROISOINDOL DERIVATIVES AS ANTAGONISTS OF THE SUBSTANCE P. Expired - Lifetime ES2123149T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9309400A FR2709752B1 (en) 1993-07-30 1993-07-30 New perhydroisoindole derivatives, their preparation and the pharmaceutical compositions containing them.
FR9311946A FR2710913B1 (en) 1993-10-07 1993-10-07 New perhydroisoindole derivatives, their preparation and the pharmaceutical compositions containing them.

Publications (1)

Publication Number Publication Date
ES2123149T3 true ES2123149T3 (en) 1999-01-01

Family

ID=26230522

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94923755T Expired - Lifetime ES2123149T3 (en) 1993-07-30 1994-07-28 PERHYDROISOINDOL DERIVATIVES AS ANTAGONISTS OF THE SUBSTANCE P.

Country Status (19)

Country Link
US (1) US5624950A (en)
EP (1) EP0711280B1 (en)
JP (1) JPH09500893A (en)
KR (1) KR960703858A (en)
AT (1) ATE171445T1 (en)
AU (1) AU7386594A (en)
CA (1) CA2168233A1 (en)
CZ (1) CZ26396A3 (en)
DE (1) DE69413542T2 (en)
DK (1) DK0711280T3 (en)
ES (1) ES2123149T3 (en)
FI (1) FI960399A0 (en)
HU (1) HUT75304A (en)
IL (1) IL110494A0 (en)
NO (1) NO960365D0 (en)
PL (1) PL312739A1 (en)
SK (1) SK13096A3 (en)
TW (1) TW365603B (en)
WO (1) WO1995004040A1 (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2727411B1 (en) * 1994-11-30 1997-01-03 Rhone Poulenc Rorer Sa NOVEL PERHYDROISOINDOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE19738339C2 (en) * 1997-09-02 2000-08-31 Siemens Ag Method for the user-controlled clearing down of wireless telecommunication connections in wireless telecommunication systems, in particular DECT systems
US6061833A (en) * 1998-12-17 2000-05-16 Wdc Holdings, Inc. Protective glove with improved wrist strap
US6784200B2 (en) 2000-10-13 2004-08-31 Bristol-Myers Squibb Pharma Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
JP2003512355A (en) 1999-10-15 2003-04-02 デュポン ファーマシューティカルズ カンパニー Bicyclic and tricyclic amines as modulators of chemokine receptor activity
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
WO2001032625A1 (en) 1999-11-03 2001-05-10 Du Pont Pharmaceuticals Company Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
JP5132864B2 (en) 2000-07-11 2013-01-30 アルバニー モレキュラー リサーチ， インコーポレイテッド 4-Phenyl substituted tetrahydroisoquinolines and methods of use thereof
AU2005274927B2 (en) 2004-07-15 2011-11-03 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US8362075B2 (en) 2005-05-17 2013-01-29 Merck Sharp & Dohme Corp. Cyclohexyl sulphones for treatment of cancer
KR101594898B1 (en) 2005-07-15 2016-02-18 알바니 몰레큘라 리써치, 인크. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
KR20080048502A (en) 2005-09-29 2008-06-02 머크 앤드 캄파니 인코포레이티드 Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US7265247B1 (en) 2006-07-28 2007-09-04 Im&T Research, Inc. Substituted phenylsulfur trifluoride and other like fluorinating agents
US8173629B2 (en) 2006-09-22 2012-05-08 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EA016079B1 (en) 2007-01-10 2012-01-30 Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти Спа Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
JP5447957B2 (en) 2007-03-23 2014-03-19 宇部興産株式会社 Method for producing aryl sulfur pentafluoride
US8399720B2 (en) 2007-03-23 2013-03-19 Ube Industries, Ltd. Methods for producing fluorinated phenylsulfur pentafluorides
JP5319518B2 (en) 2007-04-02 2013-10-16 Ｍｓｄ株式会社 Indoledione derivative
AU2008269154B2 (en) 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8030516B2 (en) 2007-10-19 2011-10-04 Ube Industries, Ltd. Methods for producing perfluoroalkanedi(sulfonyl chloride)
CN102014631A (en) 2008-03-03 2011-04-13 泰格尔医药科技公司 Tyrosine kinase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (en) 2008-07-03 2014-04-25 Ньюрексон, Інк. Benzoxazines, benzothiazines, and related compounds having nos inhibitory activity
JP5574280B2 (en) 2008-09-22 2014-08-20 宇部興産株式会社 Method for producing poly (pentafluorosulfanyl) aromatic compound
US8203003B2 (en) 2009-01-09 2012-06-19 Ube Industries, Ltd. 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
WO2010132487A1 (en) 2009-05-12 2010-11-18 Bristol-Myers Squibb Company CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
CN102458123A (en) 2009-05-12 2012-05-16 阿尔巴尼分子研究公司 Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
US8802696B2 (en) 2009-05-12 2014-08-12 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
JP5099731B1 (en) 2009-10-14 2012-12-19 メルク・シャープ・アンド・ドーム・コーポレーション Substituted piperidines that increase p53 activity and uses thereof
EP2584903B1 (en) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
AU2011285909B2 (en) 2010-08-02 2016-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
EP2606134B1 (en) 2010-08-17 2019-04-10 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
EP3766975A1 (en) 2010-10-29 2021-01-20 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
EP2699567A1 (en) 2011-04-21 2014-02-26 Merck Sharp & Dohme Corp. Insulin-like growth factor-1 receptor inhibitors
WO2013063214A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
EP3358013B1 (en) 2012-05-02 2020-06-24 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
KR20150060724A (en) 2012-09-28 2015-06-03 머크 샤프 앤드 돔 코포레이션 Novel compounds that are erk inhibitors
DK2925888T3 (en) 2012-11-28 2017-12-18 Merck Sharp & Dohme COMPOSITIONS AND METHODS OF CANCER TREATMENT
EP2935263B1 (en) 2012-12-20 2018-12-05 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
US9540377B2 (en) 2013-01-30 2017-01-10 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as HDM2 inhibitors
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
WO2018071283A1 (en) 2016-10-12 2018-04-19 Merck Sharp & Dohme Corp. Kdm5 inhibitors
US11098059B2 (en) 2017-11-08 2021-08-24 Merck Sharp & Dohme Corp. PRMT5 inhibitors
WO2019094311A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
BR112021002267A8 (en) 2018-08-07 2023-02-07 Merck Sharp & Dohme PRMT5 INHIBITORS
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors
EP3833668B1 (en) 2018-08-07 2025-03-19 Merck Sharp & Dohme LLC Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654725B1 (en) * 1989-11-23 1992-02-14 Rhone Poulenc Sante NEW ISOINDOLONE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2654726B1 (en) * 1989-11-23 1992-02-14 Rhone Poulenc Sante NEW ISOINDOLONE DERIVATIVES AND THEIR PREPARATION.
FR2676442B1 (en) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa NEW PERHYDROISOINDOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2676443B1 (en) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa NOVEL PERHYDROISOINDOLE DERIVATIVES AND THEIR PREPARATION.
FR2689889B1 (en) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa NOVEL PERHYDROISOINDOLE DERIVATIVES AND THEIR PREPARATION.
FR2689888B1 (en) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa NOVEL PERHYDROISOINDOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
FI960399A7 (en) 1996-01-29
EP0711280B1 (en) 1998-09-23
DE69413542D1 (en) 1998-10-29
FI960399A0 (en) 1996-01-29
HUT75304A (en) 1997-05-28
CZ26396A3 (en) 1996-05-15
NO960365L (en) 1996-01-29
DK0711280T3 (en) 1999-06-14
IL110494A0 (en) 1994-10-21
US5624950A (en) 1997-04-29
ATE171445T1 (en) 1998-10-15
TW365603B (en) 1999-08-01
SK13096A3 (en) 1996-09-04
HU9503986D0 (en) 1996-03-28
CA2168233A1 (en) 1995-02-09
JPH09500893A (en) 1997-01-28
AU7386594A (en) 1995-02-28
EP0711280A1 (en) 1996-05-15
DE69413542T2 (en) 1999-03-25
PL312739A1 (en) 1996-05-13
KR960703858A (en) 1996-08-31
NO960365D0 (en) 1996-01-29
WO1995004040A1 (en) 1995-02-09

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