ES2123149T3 - Derivados de perhidroisoindol como antagonistas de la substancia p. - Google Patents
Derivados de perhidroisoindol como antagonistas de la substancia p.Info
- Publication number
- ES2123149T3 ES2123149T3 ES94923755T ES94923755T ES2123149T3 ES 2123149 T3 ES2123149 T3 ES 2123149T3 ES 94923755 T ES94923755 T ES 94923755T ES 94923755 T ES94923755 T ES 94923755T ES 2123149 T3 ES2123149 T3 ES 2123149T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- alcoil
- perhydroisoindol
- antagonists
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ODSNARDHJFFSRH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-isoindole Chemical class C1CCCC2CNCC21 ODSNARDHJFFSRH-UHFFFAOYSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- -1 INDENYL Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NUEVOS DERIVADOS DE PERHIDROISOINDOL DE FORMULA GENERAL (I) EN LA QUE R{SUB,1} ES FENILO EVENTUALMENTE SUTITUIDO, CICLOHEXADIENILO, NAFTILO, INDENILO O HETEROCICLILO QUE PUEDE SER SUSTITUIDO, R{SUB,2} ES H, HALOGENO, OH, ALCOILO, AMINOALCOILO, ALCOILAMINOALCOILO, DIALCOILAMINOALCOILO, ALCOILOCI, ALCOILTIO, ACILOXI, CARBOXI, ALCOILOXICARBONILO EVENTUALMENTE SUSTITUIDO, BENCILOXICARBONILO, DIALCOILAMINOALCOILO, R{SUB,3} ES UN RADICAL FENILO, EVENTUALMENTE SUSTITUIDO EN POSICION (2) POR ALCOILO O ALCOILOXI (1 0 2C) O POR UN ATOMO DE FLUOR, O DISTRIBUIDO POR TRIFLUORMETILO Y R{SUB,5} Y R''{SUB,5} SON IDENTICO O DIFERENTES Y REPRESENTAN UNO H U OH O ALCOILO Y EL OTRO H O ALCOILO, Y R{SUB,4} ES OH, O BIEN R{SUB,4} ES OH, O BIEN R{SUB,4} ES F SI LOS SIMBOLOS R{SUB,5} Y R''{SUB,5 SON H O ALCOILO, O BIEN R{SUB,4} FORMA CON R{SUB,5} UN ENLACE , Y R{SUB,6} ES H O ALCOILO, HIDROI O HIDROXIALCOILO, Y LOS SIMBOLOS R SON UNO H, ALCOILO, HIDROXI O HIDROXIALCOILO Y EL OTRO H, ALCOILO, FENILO O HIDROXIALCOILO,BAJOS SUS FORMAS ISOMERAS DE ESTRUCTURA (IA) O SUS MEZCLAS, EVENTUALMENTE SUS SALES CUANDO EXISTEN Y SUPREPARACION. LOS NUEVOS DERIVADOS SEGUN LA INVENCION SON PARTICULARMENTE INTERESANTERS COMO ANTAGONISTAS DE LA SUSTANCIA P.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9309400A FR2709752B1 (fr) | 1993-07-30 | 1993-07-30 | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR9311946A FR2710913B1 (fr) | 1993-10-07 | 1993-10-07 | Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2123149T3 true ES2123149T3 (es) | 1999-01-01 |
Family
ID=26230522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94923755T Expired - Lifetime ES2123149T3 (es) | 1993-07-30 | 1994-07-28 | Derivados de perhidroisoindol como antagonistas de la substancia p. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5624950A (es) |
| EP (1) | EP0711280B1 (es) |
| JP (1) | JPH09500893A (es) |
| KR (1) | KR960703858A (es) |
| AT (1) | ATE171445T1 (es) |
| AU (1) | AU7386594A (es) |
| CA (1) | CA2168233A1 (es) |
| CZ (1) | CZ26396A3 (es) |
| DE (1) | DE69413542T2 (es) |
| DK (1) | DK0711280T3 (es) |
| ES (1) | ES2123149T3 (es) |
| FI (1) | FI960399A0 (es) |
| HU (1) | HUT75304A (es) |
| IL (1) | IL110494A0 (es) |
| NO (1) | NO960365L (es) |
| PL (1) | PL312739A1 (es) |
| SK (1) | SK13096A3 (es) |
| TW (1) | TW365603B (es) |
| WO (1) | WO1995004040A1 (es) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2727411B1 (fr) * | 1994-11-30 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| DE19738339C2 (de) * | 1997-09-02 | 2000-08-31 | Siemens Ag | Verfahren zum benutzergesteuerten Abbauen von drahtlosen Telekommunikationsverbindungen in drahtlosen Telekommunikationssystemen, insbesondere DECT-Systemen |
| US6061833A (en) * | 1998-12-17 | 2000-05-16 | Wdc Holdings, Inc. | Protective glove with improved wrist strap |
| US6586446B1 (en) | 1999-10-15 | 2003-07-01 | Bristol-Myers Squibb Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
| US6784200B2 (en) | 2000-10-13 | 2004-08-31 | Bristol-Myers Squibb Pharma Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
| DK1246806T3 (da) | 1999-11-03 | 2008-06-16 | Amr Technology Inc | Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin |
| US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
| MXPA03000275A (es) | 2000-07-11 | 2004-12-13 | Albany Molecular Res Inc | Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico. |
| UA91341C2 (ru) | 2004-07-15 | 2010-07-26 | Амр Текнолоджи, Інк. | Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина |
| ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
| US7956050B2 (en) | 2005-07-15 | 2011-06-07 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| KR20080048502A (ko) | 2005-09-29 | 2008-06-02 | 머크 앤드 캄파니 인코포레이티드 | 멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체 |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US7265247B1 (en) | 2006-07-28 | 2007-09-04 | Im&T Research, Inc. | Substituted phenylsulfur trifluoride and other like fluorinating agents |
| AU2007300627B2 (en) | 2006-09-22 | 2012-02-16 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| BRPI0806245B1 (pt) | 2007-01-10 | 2022-01-25 | Msd Italia S.R.L. | Compostos de fórmula i e seus usos |
| US8399720B2 (en) | 2007-03-23 | 2013-03-19 | Ube Industries, Ltd. | Methods for producing fluorinated phenylsulfur pentafluorides |
| CA2857831C (en) | 2007-03-23 | 2017-01-03 | Ube Industries, Ltd. | Process for producing arylsulfur pentafluorides |
| AU2008233662B2 (en) | 2007-04-02 | 2012-08-23 | Msd K.K. | Indoledione derivative |
| WO2009002495A1 (en) | 2007-06-27 | 2008-12-31 | Merck & Co., Inc. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| US8030516B2 (en) | 2007-10-19 | 2011-10-04 | Ube Industries, Ltd. | Methods for producing perfluoroalkanedi(sulfonyl chloride) |
| US8598184B2 (en) | 2008-03-03 | 2013-12-03 | Tiger Pharmatech | Protein kinase inhibitors |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| EP2334661B1 (en) | 2008-09-22 | 2017-08-30 | Ube Industries, Ltd. | Processes for preparing poly(pentafluorosulfanyl)aromatic compounds |
| WO2010081014A1 (en) | 2009-01-09 | 2010-07-15 | Im&T Research, Inc. | Novel 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods |
| EP2413932A4 (en) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | HAMMER OF ACT ACTIVITY |
| ES2446971T3 (es) | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
| JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用 |
| CN102595902B (zh) | 2009-05-12 | 2015-04-29 | 阿尔巴尼分子研究公司 | 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途 |
| CA2777043C (en) | 2009-10-14 | 2015-12-15 | Schering Corporation | Substituted piperidines that increase p53 activity and the uses thereof |
| EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
| CN103068980B (zh) | 2010-08-02 | 2017-04-05 | 瑟纳治疗公司 | 使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制 |
| RU2745848C2 (ru) | 2010-08-17 | 2021-04-01 | Сирна Терапьютикс, Инк. | ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) |
| US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
| EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
| US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
| WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
| WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| WO2012143879A1 (en) | 2011-04-21 | 2012-10-26 | Piramal Healthcare Limited | A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
| EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| EP3919620A1 (en) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| CA2882950A1 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| SMT201700595T1 (it) | 2012-11-28 | 2018-03-08 | Merck Sharp & Dohme | Composizioni e metodi per trattare il cancro |
| WO2014100065A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US10975084B2 (en) | 2016-10-12 | 2021-04-13 | Merck Sharp & Dohme Corp. | KDM5 inhibitors |
| WO2019094312A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| EP3706742B1 (en) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| CA3108388A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| EP3833667B1 (en) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2654726B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone et leur preparation. |
| FR2654725B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2676442B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2676443B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole et leur preparation. |
| FR2689889B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, et leur preparation. |
| FR2689888B1 (fr) * | 1992-04-10 | 1994-06-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
-
1994
- 1994-07-21 TW TW083106682A patent/TW365603B/zh active
- 1994-07-28 KR KR1019960700531A patent/KR960703858A/ko not_active Withdrawn
- 1994-07-28 JP JP7505618A patent/JPH09500893A/ja active Pending
- 1994-07-28 EP EP94923755A patent/EP0711280B1/fr not_active Expired - Lifetime
- 1994-07-28 PL PL94312739A patent/PL312739A1/xx unknown
- 1994-07-28 HU HU9503986A patent/HUT75304A/hu unknown
- 1994-07-28 AU AU73865/94A patent/AU7386594A/en not_active Abandoned
- 1994-07-28 DK DK94923755T patent/DK0711280T3/da active
- 1994-07-28 AT AT94923755T patent/ATE171445T1/de not_active IP Right Cessation
- 1994-07-28 DE DE69413542T patent/DE69413542T2/de not_active Expired - Fee Related
- 1994-07-28 US US08/586,708 patent/US5624950A/en not_active Expired - Fee Related
- 1994-07-28 SK SK130-96A patent/SK13096A3/sk unknown
- 1994-07-28 IL IL11049494A patent/IL110494A0/xx unknown
- 1994-07-28 WO PCT/FR1994/000952 patent/WO1995004040A1/fr not_active Ceased
- 1994-07-28 CA CA002168233A patent/CA2168233A1/fr not_active Abandoned
- 1994-07-28 CZ CZ96263A patent/CZ26396A3/cs unknown
- 1994-07-28 ES ES94923755T patent/ES2123149T3/es not_active Expired - Lifetime
-
1996
- 1996-01-29 NO NO960365A patent/NO960365L/no unknown
- 1996-01-29 FI FI960399A patent/FI960399A0/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0711280B1 (fr) | 1998-09-23 |
| US5624950A (en) | 1997-04-29 |
| DK0711280T3 (da) | 1999-06-14 |
| CZ26396A3 (en) | 1996-05-15 |
| NO960365D0 (no) | 1996-01-29 |
| KR960703858A (ko) | 1996-08-31 |
| HUT75304A (en) | 1997-05-28 |
| DE69413542T2 (de) | 1999-03-25 |
| WO1995004040A1 (fr) | 1995-02-09 |
| PL312739A1 (en) | 1996-05-13 |
| DE69413542D1 (de) | 1998-10-29 |
| ATE171445T1 (de) | 1998-10-15 |
| FI960399A7 (fi) | 1996-01-29 |
| SK13096A3 (en) | 1996-09-04 |
| TW365603B (en) | 1999-08-01 |
| NO960365L (no) | 1996-01-29 |
| AU7386594A (en) | 1995-02-28 |
| FI960399A0 (fi) | 1996-01-29 |
| HU9503986D0 (en) | 1996-03-28 |
| CA2168233A1 (fr) | 1995-02-09 |
| IL110494A0 (en) | 1994-10-21 |
| EP0711280A1 (fr) | 1996-05-15 |
| JPH09500893A (ja) | 1997-01-28 |
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