ES2123149T3 - Derivados de perhidroisoindol como antagonistas de la substancia p. - Google Patents

Derivados de perhidroisoindol como antagonistas de la substancia p.

Info

Publication number
ES2123149T3
ES2123149T3 ES94923755T ES94923755T ES2123149T3 ES 2123149 T3 ES2123149 T3 ES 2123149T3 ES 94923755 T ES94923755 T ES 94923755T ES 94923755 T ES94923755 T ES 94923755T ES 2123149 T3 ES2123149 T3 ES 2123149T3
Authority
ES
Spain
Prior art keywords
sub
alcoil
perhydroisoindol
antagonists
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94923755T
Other languages
English (en)
Inventor
Daniel Achard
Serge Grisoni
Evelyne James-Surcouf
Jean-Luc Malleron
Anne Morgat
Jean-Francois Peyronel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9309400A external-priority patent/FR2709752B1/fr
Priority claimed from FR9311946A external-priority patent/FR2710913B1/fr
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2123149T3 publication Critical patent/ES2123149T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NUEVOS DERIVADOS DE PERHIDROISOINDOL DE FORMULA GENERAL (I) EN LA QUE R{SUB,1} ES FENILO EVENTUALMENTE SUTITUIDO, CICLOHEXADIENILO, NAFTILO, INDENILO O HETEROCICLILO QUE PUEDE SER SUSTITUIDO, R{SUB,2} ES H, HALOGENO, OH, ALCOILO, AMINOALCOILO, ALCOILAMINOALCOILO, DIALCOILAMINOALCOILO, ALCOILOCI, ALCOILTIO, ACILOXI, CARBOXI, ALCOILOXICARBONILO EVENTUALMENTE SUSTITUIDO, BENCILOXICARBONILO, DIALCOILAMINOALCOILO, R{SUB,3} ES UN RADICAL FENILO, EVENTUALMENTE SUSTITUIDO EN POSICION (2) POR ALCOILO O ALCOILOXI (1 0 2C) O POR UN ATOMO DE FLUOR, O DISTRIBUIDO POR TRIFLUORMETILO Y R{SUB,5} Y R''{SUB,5} SON IDENTICO O DIFERENTES Y REPRESENTAN UNO H U OH O ALCOILO Y EL OTRO H O ALCOILO, Y R{SUB,4} ES OH, O BIEN R{SUB,4} ES OH, O BIEN R{SUB,4} ES F SI LOS SIMBOLOS R{SUB,5} Y R''{SUB,5 SON H O ALCOILO, O BIEN R{SUB,4} FORMA CON R{SUB,5} UN ENLACE , Y R{SUB,6} ES H O ALCOILO, HIDROI O HIDROXIALCOILO, Y LOS SIMBOLOS R SON UNO H, ALCOILO, HIDROXI O HIDROXIALCOILO Y EL OTRO H, ALCOILO, FENILO O HIDROXIALCOILO,BAJOS SUS FORMAS ISOMERAS DE ESTRUCTURA (IA) O SUS MEZCLAS, EVENTUALMENTE SUS SALES CUANDO EXISTEN Y SUPREPARACION. LOS NUEVOS DERIVADOS SEGUN LA INVENCION SON PARTICULARMENTE INTERESANTERS COMO ANTAGONISTAS DE LA SUSTANCIA P.
ES94923755T 1993-07-30 1994-07-28 Derivados de perhidroisoindol como antagonistas de la substancia p. Expired - Lifetime ES2123149T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9309400A FR2709752B1 (fr) 1993-07-30 1993-07-30 Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR9311946A FR2710913B1 (fr) 1993-10-07 1993-10-07 Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2123149T3 true ES2123149T3 (es) 1999-01-01

Family

ID=26230522

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94923755T Expired - Lifetime ES2123149T3 (es) 1993-07-30 1994-07-28 Derivados de perhidroisoindol como antagonistas de la substancia p.

Country Status (19)

Country Link
US (1) US5624950A (es)
EP (1) EP0711280B1 (es)
JP (1) JPH09500893A (es)
KR (1) KR960703858A (es)
AT (1) ATE171445T1 (es)
AU (1) AU7386594A (es)
CA (1) CA2168233A1 (es)
CZ (1) CZ26396A3 (es)
DE (1) DE69413542T2 (es)
DK (1) DK0711280T3 (es)
ES (1) ES2123149T3 (es)
FI (1) FI960399A7 (es)
HU (1) HUT75304A (es)
IL (1) IL110494A0 (es)
NO (1) NO960365D0 (es)
PL (1) PL312739A1 (es)
SK (1) SK13096A3 (es)
TW (1) TW365603B (es)
WO (1) WO1995004040A1 (es)

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FR2727411B1 (fr) * 1994-11-30 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
DE19738339C2 (de) * 1997-09-02 2000-08-31 Siemens Ag Verfahren zum benutzergesteuerten Abbauen von drahtlosen Telekommunikationsverbindungen in drahtlosen Telekommunikationssystemen, insbesondere DECT-Systemen
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CA2386049A1 (en) 1999-10-15 2001-04-26 Daniel S. Gardner Bicyclic and tricyclic amines as modulators of chemokine receptor activity
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
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CA2415532C (en) 2000-07-11 2010-05-11 Albany Molecular Research, Inc. Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
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US8293900B2 (en) 2005-09-29 2012-10-23 Merck Sharp & Dohme Corp Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
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EP2698157B1 (en) 2006-09-22 2015-05-20 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2805945B1 (en) 2007-01-10 2019-04-03 MSD Italia S.r.l. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
US8399720B2 (en) 2007-03-23 2013-03-19 Ube Industries, Ltd. Methods for producing fluorinated phenylsulfur pentafluorides
EP2137144B1 (en) 2007-03-23 2013-07-31 UBE Industries, Ltd. Process for producing arylsulfur pentafluorides
US8106086B2 (en) 2007-04-02 2012-01-31 Msd K.K. Indoledione derivative
US8389553B2 (en) 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8030516B2 (en) 2007-10-19 2011-10-04 Ube Industries, Ltd. Methods for producing perfluoroalkanedi(sulfonyl chloride)
KR20100126467A (ko) 2008-03-03 2010-12-01 타이거 파마테크 티로신 키나아제 억제제
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
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CN103382173A (zh) 2008-09-22 2013-11-06 宇部兴产株式会社 制备多(五氟硫烷基)芳香化合物的方法
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Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654726B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone et leur preparation.
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676443B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole et leur preparation.
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, et leur preparation.
FR2689888B1 (fr) * 1992-04-10 1994-06-10 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
SK13096A3 (en) 1996-09-04
NO960365L (no) 1996-01-29
AU7386594A (en) 1995-02-28
DK0711280T3 (da) 1999-06-14
CZ26396A3 (en) 1996-05-15
PL312739A1 (en) 1996-05-13
WO1995004040A1 (fr) 1995-02-09
IL110494A0 (en) 1994-10-21
NO960365D0 (no) 1996-01-29
HU9503986D0 (en) 1996-03-28
JPH09500893A (ja) 1997-01-28
DE69413542D1 (de) 1998-10-29
DE69413542T2 (de) 1999-03-25
EP0711280B1 (fr) 1998-09-23
HUT75304A (en) 1997-05-28
TW365603B (en) 1999-08-01
CA2168233A1 (fr) 1995-02-09
EP0711280A1 (fr) 1996-05-15
US5624950A (en) 1997-04-29
FI960399A0 (fi) 1996-01-29
KR960703858A (ko) 1996-08-31
FI960399A7 (fi) 1996-01-29
ATE171445T1 (de) 1998-10-15

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