ES2123562T3 - Procedimiento para la preparacion de (s)-4-(3-(5-metil-2-fenil-4-oxazolil)-1-hidroxipropil)bromobenceno. - Google Patents

Procedimiento para la preparacion de (s)-4-(3-(5-metil-2-fenil-4-oxazolil)-1-hidroxipropil)bromobenceno.

Info

Publication number
ES2123562T3
ES2123562T3 ES92915192T ES92915192T ES2123562T3 ES 2123562 T3 ES2123562 T3 ES 2123562T3 ES 92915192 T ES92915192 T ES 92915192T ES 92915192 T ES92915192 T ES 92915192T ES 2123562 T3 ES2123562 T3 ES 2123562T3
Authority
ES
Spain
Prior art keywords
preparation
hydroxypropil
bromobenzene
oxazolyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92915192T
Other languages
English (en)
Inventor
George J Quallich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2123562T3 publication Critical patent/ES2123562T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTA UN PROCESO PARA LA PREPARACION ESTEROSELECTIVA DE PRODUCTOS INTERMEDIOS EN LA PREPARACION DE HIPOGLICEMICOS DE TIAZOLIDINA-2,4-DIONA DE QUIRAL, DE ACCION POTENTE.
ES92915192T 1991-07-22 1992-07-01 Procedimiento para la preparacion de (s)-4-(3-(5-metil-2-fenil-4-oxazolil)-1-hidroxipropil)bromobenceno. Expired - Lifetime ES2123562T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73356491A 1991-07-22 1991-07-22

Publications (1)

Publication Number Publication Date
ES2123562T3 true ES2123562T3 (es) 1999-01-16

Family

ID=24948157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92915192T Expired - Lifetime ES2123562T3 (es) 1991-07-22 1992-07-01 Procedimiento para la preparacion de (s)-4-(3-(5-metil-2-fenil-4-oxazolil)-1-hidroxipropil)bromobenceno.

Country Status (21)

Country Link
US (1) US5512689A (es)
EP (1) EP0595868B1 (es)
JP (1) JP2671962B2 (es)
AT (1) ATE173728T1 (es)
AU (1) AU660701B2 (es)
CA (1) CA2111445C (es)
DE (1) DE69227689T2 (es)
DK (1) DK0595868T3 (es)
ES (1) ES2123562T3 (es)
FI (1) FI940306A7 (es)
HU (1) HUT70412A (es)
IE (1) IE922359A1 (es)
IL (1) IL102574A (es)
MX (1) MX9204278A (es)
MY (1) MY131277A (es)
NO (1) NO940227D0 (es)
NZ (1) NZ243651A (es)
PT (1) PT100710B (es)
TW (1) TW199891B (es)
WO (1) WO1993002060A1 (es)
ZA (1) ZA925469B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0641331A1 (en) * 1991-07-22 1995-03-08 Pfizer Inc. Chiral intermediates for the preparation of antidiabetics thiazoles
FR2699172B1 (fr) * 1992-12-11 1995-01-20 Adir Nouveaux dérivés de 4-méthyl-1,3-oxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
TW416958B (en) * 1993-05-14 2001-01-01 Pfizer Enantioselective oxazaborolidine catalysts
BR0013671A (pt) 1999-08-31 2003-06-10 Maxia Pharmaceuticals Inc Derivados heterocìclicos para o tratamento do diabetes e outras doenças
WO2002072009A2 (en) 2001-03-07 2002-09-19 Maxia Pharmaceuticals, Inc. Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
JP2004523571A (ja) * 2001-03-08 2004-08-05 マキシア・ファーマシューティカルズ・インコーポレイテッド Ｒｘｒ活性化分子
CA2340824A1 (en) * 2001-03-14 2002-09-14 Ibm Canada Limited-Ibm Canada Limitee Method and system for application behavior analysis
JP2005500379A (ja) * 2001-08-17 2005-01-06 インサイト サンディエゴ インコーポレーテッド 異脂肪血症および高コレステロール血症を治療するオキシム誘導体
EP1456187A4 (en) * 2001-11-15 2005-02-09 Incyte San Diego Inc N-SUBSTITUTED HETEROCYCLES FOR THE TREATMENT OF HYPERCHOLESTERINEMIA, DYSLIPIDEMIA AND OTHER METABOLIC DISORDER, CANCER AND OTHER DISEASES
US7196108B2 (en) * 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US20050014767A1 (en) * 2003-01-29 2005-01-20 Magnus Pfahl Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
ZA200509355B (en) * 2003-04-18 2007-03-28 Incyte San Diego Inc Substituted isochroman compounds for the treatment of metabolic disorders, cancer and other diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
US5036079A (en) * 1989-12-07 1991-07-30 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
TW222626B (es) * 1991-07-22 1994-04-21 Pfizer

Also Published As

Publication number Publication date
HUT70412A (en) 1995-10-30
IL102574A0 (en) 1993-01-14
WO1993002060A1 (en) 1993-02-04
DE69227689T2 (de) 1999-04-22
FI940306A0 (fi) 1994-01-21
MY131277A (en) 2007-07-31
DK0595868T3 (da) 1999-08-09
NZ243651A (en) 1994-01-26
CA2111445C (en) 1997-02-18
ATE173728T1 (de) 1998-12-15
FI940306L (fi) 1994-01-21
JPH07502017A (ja) 1995-03-02
IL102574A (en) 1996-07-23
NO940227L (no) 1994-01-21
IE922359A1 (en) 1993-01-27
NO940227D0 (no) 1994-01-21
AU660701B2 (en) 1995-07-06
AU2306292A (en) 1993-02-23
EP0595868B1 (en) 1998-11-25
EP0595868A1 (en) 1994-05-11
CA2111445A1 (en) 1993-02-04
MX9204278A (es) 1994-03-31
FI940306A7 (fi) 1994-01-21
TW199891B (es) 1993-02-11
JP2671962B2 (ja) 1997-11-05
HU9400188D0 (en) 1994-05-30
US5512689A (en) 1996-04-30
PT100710A (pt) 1993-09-30
DE69227689D1 (de) 1999-01-07
PT100710B (pt) 1999-07-30
ZA925469B (en) 1994-01-21

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