ES2123714T3 - Aislamiento y estructura de las esponjistatinas 5,7,8 y 9 y su empleo como agentes antitumorales. - Google Patents

Aislamiento y estructura de las esponjistatinas 5,7,8 y 9 y su empleo como agentes antitumorales.

Info

Publication number
ES2123714T3
ES2123714T3 ES94304809T ES94304809T ES2123714T3 ES 2123714 T3 ES2123714 T3 ES 2123714T3 ES 94304809 T ES94304809 T ES 94304809T ES 94304809 T ES94304809 T ES 94304809T ES 2123714 T3 ES2123714 T3 ES 2123714T3
Authority
ES
Spain
Prior art keywords
spongistatine
sponge
jacks
isolation
discovered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94304809T
Other languages
English (en)
Inventor
George R Pettit
Zbigniew A Cichacz
Cherry L Herald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Arizona
Arizona's Public Universities
Original Assignee
University of Arizona
Arizona's Public Universities
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Arizona, Arizona's Public Universities filed Critical University of Arizona
Application granted granted Critical
Publication of ES2123714T3 publication Critical patent/ES2123714T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE HA DESCUBIERTO QUE UNA ESPONJA MARINA DEL SUDOESTE DEL OCEANO INDICO, LA "SPIRASTRELLA SPINISPIRULIFERA" (DE COLORES ROJOS Y PURPURAS MUY BRILLANTES) CONTIENE ESPONGISTATINA 5, ESPONGISTATINA 7, ESPONGISTATINA 8 Y ESPONGISTATINA 6 INHIBIDORAS DEL CRECIMIENTO DE CELULAS (DE CANCER HUMANO) NUEVAS Y EXCEPCIONALMENTE ACTIVAS. ESTAS COMPOSICIONES ESTAN RELACIONADAS CON ESPONGISTANINA 1, QUE SE HA ENCONTRADO EN UNA "SPONGIA SP." NEGRA DE LA FAMILIA PORIFERA. TAMBIEN SE DESCUBRE UN METODO PARA TRATAR CELULAS CANCERIGENAS HUMANAS CON ESPONGISTATINA 5 Y ESPONGISTATINA 7.
ES94304809T 1993-07-02 1994-06-30 Aislamiento y estructura de las esponjistatinas 5,7,8 y 9 y su empleo como agentes antitumorales. Expired - Lifetime ES2123714T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/086,664 US5393897A (en) 1993-07-02 1993-07-02 Isolation and structure of spongistatins 5,7,8 and 9

Publications (1)

Publication Number Publication Date
ES2123714T3 true ES2123714T3 (es) 1999-01-16

Family

ID=22200068

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94304809T Expired - Lifetime ES2123714T3 (es) 1993-07-02 1994-06-30 Aislamiento y estructura de las esponjistatinas 5,7,8 y 9 y su empleo como agentes antitumorales.

Country Status (9)

Country Link
US (1) US5393897A (es)
EP (1) EP0634414B1 (es)
JP (1) JP3430322B2 (es)
AT (1) ATE169919T1 (es)
CA (1) CA2126910C (es)
DE (1) DE69412551T2 (es)
DK (1) DK0634414T3 (es)
ES (1) ES2123714T3 (es)
MX (1) MX9404999A (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883120A (en) * 1997-06-16 1999-03-16 Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University Antifungal activity of the spongistatins
WO1997048278A1 (en) * 1996-06-18 1997-12-24 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of The Arizona State University Antifungal activity of the spongistatins
US5952376A (en) * 1997-11-07 1999-09-14 The Trustees Of The University Of Pennsylvania Trienyl compounds
US6521661B1 (en) 2000-07-20 2003-02-18 Harbor Branch Oceanographic Institution, Inc. Cyclic peroxides as novel antifungal agents
ATE411019T1 (de) * 2001-05-02 2008-10-15 Brni Neurosciences Inst Kohlensäureanhydrase-aktivatoren zur verbesserung der lern- und gedächtnisleistung
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
TW201206425A (en) * 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
US20070054890A1 (en) * 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
CA2659242C (en) 2006-07-28 2015-08-11 Blanchette Rockefeller Neurosciences Institute Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory
EP2121001B1 (en) 2007-02-09 2014-12-17 Blanchette Rockefeller Neurosciences, Institute Therapeutic effects of bryostatins on ischemia/stroke-induced memory impairment and brain injury
KR20140049054A (ko) * 2007-02-09 2014-04-24 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 두부 외상으로 유발된 기억 장애 및 뇌 손상에 대한 브리오스타틴, 브리오로그 및 기타 관련 물질의 치료학적 효과
US9053844B2 (en) * 2009-09-09 2015-06-09 Littelfuse, Inc. Geometric configuration or alignment of protective material in a gap structure for electrical devices
US9107890B2 (en) 2010-07-08 2015-08-18 Blanchette Rockefeller Neurosciences Institute PKC activators and anticoagulant in regimen for treating stroke
CA2808660A1 (en) 2010-08-19 2012-02-23 Blanchette Rockefeller Neurosciences Institute Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators
JP6422778B2 (ja) 2011-11-13 2018-11-14 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート Ｐｋｃアクチベーターおよびその組合せ
WO2016130969A1 (en) 2015-02-13 2016-08-18 George Robert Pettit Silstatin compounds
JP2018521113A (ja) 2015-05-11 2018-08-02 アルコン、ダニエル・エル． ＡｐｏＥ４対立遺伝子の存在を決定した後のＰＫＣ活性化因子を使用した神経変性状態の治療
US11629167B2 (en) 2017-11-09 2023-04-18 Arizona Board Of Regents On Behalf Of Arizona State University Betulastatin compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164584A (en) * 1977-10-25 1979-08-14 Research Corporation Anti-leukemic trichothecene epoxides
US4560774A (en) * 1982-11-17 1985-12-24 Arizona State University Macrocyclic lactones
US4996229A (en) * 1985-06-06 1991-02-26 University Of Hawaii Scytophycins
DE3669515D1 (de) * 1985-09-13 1990-04-19 Biotechnolog Forschung Gmbh Makrozyklische antibiotika.
US4833257A (en) * 1986-07-28 1989-05-23 Arizona Board Of Regents Compositions of matter and methods of using same
US4940726A (en) * 1989-04-26 1990-07-10 Arizona Board Of Regents Cell growth inhibitory macrocyclic lactones denominated Combretastatin D-1 and Combretastatin D-2
US5436400A (en) * 1993-01-19 1995-07-25 Arizona Board Of Regents Isolation and structure of spongistatin 1
US5328929A (en) * 1993-07-02 1994-07-12 Arizona Board Of Regents Isolation and structure of spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6

Also Published As

Publication number Publication date
JPH07157428A (ja) 1995-06-20
ATE169919T1 (de) 1998-09-15
DE69412551T2 (de) 1999-02-04
DE69412551D1 (de) 1998-09-24
DK0634414T3 (da) 1999-05-25
EP0634414B1 (en) 1998-08-19
CA2126910A1 (en) 1995-01-03
US5393897A (en) 1995-02-28
CA2126910C (en) 2001-07-17
EP0634414A1 (en) 1995-01-18
MX9404999A (es) 1995-01-31
JP3430322B2 (ja) 2003-07-28

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