ES2124231T3 - Procedimiento mejorado para sintesis de oligomeros. - Google Patents

Procedimiento mejorado para sintesis de oligomeros.

Info

Publication number
ES2124231T3
ES2124231T3 ES91919675T ES91919675T ES2124231T3 ES 2124231 T3 ES2124231 T3 ES 2124231T3 ES 91919675 T ES91919675 T ES 91919675T ES 91919675 T ES91919675 T ES 91919675T ES 2124231 T3 ES2124231 T3 ES 2124231T3
Authority
ES
Spain
Prior art keywords
oligomers
synthesis
improved procedure
methods
result
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91919675T
Other languages
English (en)
Inventor
Robert E Klem
William B Marvin
Timothy A Riley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genta Inc
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Application granted granted Critical
Publication of ES2124231T3 publication Critical patent/ES2124231T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PROPORCIONAN METODOS DE SINTETIZAR OLIGOMEROS USANDO REACTIVOS OXIDANTES CON POCA AGUA, LO CUAL RESULTA EN EFICIENCIAS DE ACOPLAMIENTO ELEVADO. ESTOS METODOS SON ADECUADOS PARA PREPARACIONES DE AMPLIA ESCALA DE OLIGOMEROS METILOFOSFATO.
ES91919675T 1990-10-26 1991-10-21 Procedimiento mejorado para sintesis de oligomeros. Expired - Lifetime ES2124231T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60579090A 1990-10-26 1990-10-26

Publications (1)

Publication Number Publication Date
ES2124231T3 true ES2124231T3 (es) 1999-02-01

Family

ID=24425218

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91919675T Expired - Lifetime ES2124231T3 (es) 1990-10-26 1991-10-21 Procedimiento mejorado para sintesis de oligomeros.

Country Status (14)

Country Link
US (1) US5726300A (es)
EP (1) EP0592434B1 (es)
JP (1) JPH06509542A (es)
AT (1) ATE171947T1 (es)
AU (1) AU669103B2 (es)
CA (1) CA2094803A1 (es)
DE (1) DE69130331T2 (es)
DK (1) DK0592434T3 (es)
ES (1) ES2124231T3 (es)
IE (1) IE913761A1 (es)
IL (1) IL99844A (es)
NZ (1) NZ240325A (es)
TW (1) TW216423B (es)
WO (1) WO1992007864A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012135A1 (en) 1991-12-12 1993-06-24 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
WO1994001446A2 (en) * 1992-07-09 1994-01-20 Beckman Instruments, Inc. Derivatized organic solid support for nucleic acid synthesis
FR2707296B1 (fr) * 1993-07-09 1995-09-29 Genset Sa Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé.
AU688364B2 (en) * 1993-07-19 1998-03-12 Gen-Probe Incorporated Oligonucleotides with activity against human immunodeficiency virus
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
JP3789471B2 (ja) * 1993-07-19 2006-06-21 ジェン−プローブ・インコーポレイテッド オリゴヌクレオチドスクリーニングアッセイ
US5733781A (en) 1994-07-19 1998-03-31 Gen-Probe Incorporated Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus
DK0805876T3 (da) * 1995-01-19 2000-11-06 Gen Probe Inc Nukleinsyreamplifikationsoligonukleotider og prober til Lyme-sygdom-associeret Borrelia
US5747470A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
US5674995A (en) * 1995-06-07 1997-10-07 Gen-Probe Incorporated Oligonucleotides specific for cytokine signal transducer gp130 mRNA
US5716846A (en) * 1995-06-07 1998-02-10 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6146833A (en) * 1997-02-11 2000-11-14 Beckman Coulter, Inc. Polymeric reagents for immobilizing biopolymers
US6932943B1 (en) 2001-01-26 2005-08-23 Third Wave Technologies Nucleic acid synthesizers
US7435390B2 (en) * 2001-01-26 2008-10-14 Third Wave Technologies, Inc. Nucleic acid synthesizers
US20030072689A1 (en) * 2001-08-15 2003-04-17 Third Wave Technologies, Inc. Polymer synthesizer
US9051601B2 (en) 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
WO2009124150A2 (en) 2008-04-01 2009-10-08 Biosearch Technologies, Inc. Stabilized nucleic acid dark quencher-fluorophore probes
US10913767B2 (en) * 2010-04-22 2021-02-09 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising acyclic and abasic nucleosides and analogs
CN104736551B (zh) * 2012-08-15 2017-07-28 Ionis制药公司 使用改进的封端方案制备寡聚化合物的方法
CN106536483B (zh) 2014-05-09 2020-02-07 生物检索技术股份有限公司 Cosmic猝灭剂
WO2016160646A1 (en) * 2015-04-02 2016-10-06 Merck Sharp & Dohme Corp. Process for making phosphoramidate protected nucleoside compounds
EP3283499B1 (en) 2015-04-15 2022-07-06 Biosearch Technologies, Inc. Dual quencher probes
CN110612354B (zh) 2017-05-11 2025-02-11 简·探针公司 用于分离靶核酸的组合物和方法
CN116287111A (zh) 2019-11-14 2023-06-23 简·探针公司 用于捕获靶核酸的组合物和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US4923901A (en) * 1987-09-04 1990-05-08 Millipore Corporation Membranes with bound oligonucleotides and peptides

Also Published As

Publication number Publication date
NZ240325A (en) 1993-06-25
EP0592434A4 (en) 1996-04-24
TW216423B (es) 1993-11-21
EP0592434B1 (en) 1998-10-07
ATE171947T1 (de) 1998-10-15
JPH06509542A (ja) 1994-10-27
WO1992007864A1 (en) 1992-05-14
EP0592434A1 (en) 1994-04-20
US5726300A (en) 1998-03-10
DK0592434T3 (da) 1999-06-21
DE69130331T2 (de) 1999-03-04
AU8875391A (en) 1992-05-26
CA2094803A1 (en) 1992-04-27
DE69130331D1 (de) 1998-11-12
IE913761A1 (en) 1992-05-22
AU669103B2 (en) 1996-05-30
IL99844A (en) 1995-07-31

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