DK0678096T3 - Syntese af dimerblokke og deres anvendelse til aggregering af oligonukleotider - Google Patents

Syntese af dimerblokke og deres anvendelse til aggregering af oligonukleotider

Info

Publication number
DK0678096T3
DK0678096T3 DK94906568.4T DK94906568T DK0678096T3 DK 0678096 T3 DK0678096 T3 DK 0678096T3 DK 94906568 T DK94906568 T DK 94906568T DK 0678096 T3 DK0678096 T3 DK 0678096T3
Authority
DK
Denmark
Prior art keywords
oligonucleotides
dimer blocks
aggregating
synthesis
blocks
Prior art date
Application number
DK94906568.4T
Other languages
English (en)
Inventor
Sudhir Agrawal
Jin-Yan Tang
Patricia L Iadarola
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Application granted granted Critical
Publication of DK0678096T3 publication Critical patent/DK0678096T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK94906568.4T 1993-01-08 1994-01-07 Syntese af dimerblokke og deres anvendelse til aggregering af oligonukleotider DK0678096T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US282393A 1993-01-08 1993-01-08

Publications (1)

Publication Number Publication Date
DK0678096T3 true DK0678096T3 (da) 1997-08-18

Family

ID=21702683

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94906568.4T DK0678096T3 (da) 1993-01-08 1994-01-07 Syntese af dimerblokke og deres anvendelse til aggregering af oligonukleotider

Country Status (13)

Country Link
EP (1) EP0678096B1 (da)
JP (1) JPH08507752A (da)
KR (1) KR960700262A (da)
CN (1) CN1122137A (da)
AT (1) ATE150464T1 (da)
CA (1) CA2153505A1 (da)
DE (1) DE69402177T2 (da)
DK (1) DK0678096T3 (da)
ES (1) ES2100051T3 (da)
FI (1) FI953363A0 (da)
GR (1) GR3023123T3 (da)
NZ (1) NZ261480A (da)
WO (1) WO1994015946A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
WO1996029337A1 (en) * 1995-03-23 1996-09-26 Hybridon, Inc. Thiono triester modified antisense oligodeoxynucleotide phosphorothioates
US5856464A (en) * 1995-06-07 1999-01-05 Lajolla Pharmaceutical Company Selective capping solution phase oligonucleotide synthesis
US6172217B1 (en) * 1996-12-27 2001-01-09 Isis Pharmaceuticals Inc. Method of synthesizing phosphorothioate oligonucleotides
US5760209A (en) * 1997-03-03 1998-06-02 Isis Pharmaceuticals, Inc. Protecting group for synthesizing oligonucleotide analogs
US5902881A (en) * 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
US6380378B1 (en) 1998-12-24 2002-04-30 Toagosei Company, Ltd. Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
US6207819B1 (en) * 1999-02-12 2001-03-27 Isis Pharmaceuticals, Inc. Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
DK1196129T3 (da) 1999-06-25 2006-04-03 Az Univ Amsterdam Farmaceutiske og kosmetiske sammensætninger omfattende urocaninsyrederivater som radikalscavengers eller antioxidanter
CN102344477B (zh) * 2010-07-27 2015-04-08 苏州瑞博生物技术有限公司 一种核苷酸和/或寡核苷酸及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
DE3332068A1 (de) * 1983-09-06 1985-03-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
FR2596761B1 (fr) * 1986-04-08 1988-05-20 Commissariat Energie Atomique Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
US5194428A (en) * 1986-05-23 1993-03-16 Worcester Foundation For Experimental Biology Inhibition of influenza virus replication by oligonucleotide phosphorothioates
US5449769A (en) * 1989-03-06 1995-09-12 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
US5003097A (en) * 1989-10-02 1991-03-26 The United States Of America As Represented By The Department Of Health And Human Services Method for the sulfurization of phosphorous groups in compounds
DE69034150T2 (de) * 1989-10-24 2005-08-25 Isis Pharmaceuticals, Inc., Carlsbad 2'-Modifizierte Oligonukleotide
AU642673B2 (en) * 1990-09-04 1993-10-28 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
WO1992020967A1 (en) * 1991-05-10 1992-11-26 Scholer Incineration Co Pty Ltd Incinerator
KR930016437A (ko) * 1992-01-22 1993-08-26 귀틀라인, 슈미트 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도
ATE162198T1 (de) * 1992-07-27 1998-01-15 Hybridon Inc Oligonukleotid alkylphosphonothiate

Also Published As

Publication number Publication date
NZ261480A (en) 1997-05-26
KR960700262A (ko) 1996-01-19
DE69402177D1 (de) 1997-04-24
CA2153505A1 (en) 1994-07-21
JPH08507752A (ja) 1996-08-20
FI953363A7 (fi) 1995-07-07
EP0678096B1 (en) 1997-03-19
CN1122137A (zh) 1996-05-08
WO1994015946A1 (en) 1994-07-21
AU6024394A (en) 1994-08-15
FI953363L (fi) 1995-07-07
FI953363A0 (fi) 1995-07-07
GR3023123T3 (en) 1997-07-30
DE69402177T2 (de) 1997-06-26
ATE150464T1 (de) 1997-04-15
ES2100051T3 (es) 1997-06-01
EP0678096A1 (en) 1995-10-25
AU673051B2 (en) 1996-10-24

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