ES2126061T3 - Piridopirimidinas substituidas como antihipertensores. - Google Patents
Piridopirimidinas substituidas como antihipertensores.Info
- Publication number
- ES2126061T3 ES2126061T3 ES94301881T ES94301881T ES2126061T3 ES 2126061 T3 ES2126061 T3 ES 2126061T3 ES 94301881 T ES94301881 T ES 94301881T ES 94301881 T ES94301881 T ES 94301881T ES 2126061 T3 ES2126061 T3 ES 2126061T3
- Authority
- ES
- Spain
- Prior art keywords
- alkilo
- carboxi
- hydroxy
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 4
- -1 CARBONYL GROUP Chemical group 0.000 abstract 3
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- WFUJPKYTFSXASN-UHFFFAOYSA-N stannyl Chemical class [SnH3] WFUJPKYTFSXASN-UHFFFAOYSA-N 0.000 abstract 1
- OHSJPLSEQNCRLW-UHFFFAOYSA-N triphenylmethyl radical Chemical class C1=CC=CC=C1[C](C=1C=CC=CC=1)C1=CC=CC=C1 OHSJPLSEQNCRLW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
ESTA INVENCION SE REFIERE A PIRIDOPIRIMIDINONAS SUSTITUIDAS DE LA FORMULA GENERAL (I): EN LA QUE N ES DE 0 A 3; R1 Y R2 SON, INDEPENDIENTEMENTE, H, ALKILO C1-C6, HIDROXI(ALKILO C1-C6), FORMILO, CARBONIL(ALKILO C1-C6), CARBOXI O CARBOXI(ALKILO C1-C6); R3 Y R4 SON, INDEPENDIENTEMENTE, H, ALKILO C1-C6 O HIDROXI; R3A Y R4A SON H, O UNO DE ENTRE -CR3R3A Y -CR4R4A ES UN GRUPO CARBONILO; AL MENOS UNO DE LOS GRUPOS R1 Y R2 DEBE SER HIDROXI(ALKILO C1-C6), FORMILO, CARBONIL(ALKILO C1-C6), CARBOXI O CARBOXI(ALKILO C1-C6); O UNO DE ENTRE R3 Y R4 DEBE SER HIDROXI; O UNO DE ENTRE -CR3R3A Y -CR4R4A DEBES SER UN GRUPO CARBONILO; AR1 ES EN DONDE W ES H, ALKILO C1-C6, HALOGENO, HIDROXI O ALCOXI C1-C6; AR2 ES EN DONDE X ES CO2H, CN O EN DONDE R5 ES H, CH3, TERC-BUTILO, TRI-N-BUTILESTANNILO O TRIFENILMETILO; O UN TAUTOMERO DE DICHO COMPUESTO O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE DICHO COMPUESTO O TAUTOMERO. LOS COMPUESTOS DE LA FORMULA I SON UTILES PARA EL TRATAMIENTO DE LA HIPERTENSION Y DEL COLAPSO CONGESTIVO. TAMBIEN SE PRESENTAN LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LOS COMPUESTOS DE LA FORMULA I Y UN SOPORTE FARMACEUTICAMENTE ACEPTABLE Y LOS METODOS PARA LA PRODUCCION DE LOS COMPUESTOS DE LA FORMULA I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3661593A | 1993-03-24 | 1993-03-24 | |
| US08/179,461 US5466692A (en) | 1993-03-24 | 1994-01-10 | Substituted pyridopyrimidines and antihypertensives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2126061T3 true ES2126061T3 (es) | 1999-03-16 |
Family
ID=26713326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94301881T Expired - Lifetime ES2126061T3 (es) | 1993-03-24 | 1994-03-16 | Piridopirimidinas substituidas como antihipertensores. |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP0618207B1 (es) |
| JP (1) | JPH06321945A (es) |
| AT (1) | ATE175413T1 (es) |
| AU (1) | AU669966B2 (es) |
| BR (1) | BR9401261A (es) |
| CA (1) | CA2119692A1 (es) |
| DE (1) | DE69415706T2 (es) |
| DK (1) | DK0618207T3 (es) |
| ES (1) | ES2126061T3 (es) |
| FI (1) | FI108135B (es) |
| GR (1) | GR3029879T3 (es) |
| HU (1) | HU222240B1 (es) |
| LV (1) | LV12261B (es) |
| NZ (1) | NZ260164A (es) |
| PH (1) | PH30373A (es) |
| SG (1) | SG47714A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0104634A3 (en) | 1998-07-06 | 2002-11-28 | Bristol Myers Squibb Co | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
| KR101530019B1 (ko) * | 2007-06-07 | 2015-06-18 | 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. | 혈관성형술 또는 동맥내막절제술 후 재협착 및 장기 섬유증으로 인한 질환의 치료에 유용한 5베타, 14베타-안드로스테인 유도체 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US521797A (en) * | 1894-06-26 | Half to john m | ||
| BG94957A (bg) * | 1990-08-10 | 1993-12-24 | Ciba - Geigy Ag | Пиримидинови производни и средство за борба срещу вредители по растенията |
| US5290780A (en) * | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
| IL100917A0 (en) * | 1991-02-16 | 1992-11-15 | Fisons Plc | Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them |
| IL101860A0 (en) * | 1991-05-31 | 1992-12-30 | Ici Plc | Heterocyclic derivatives |
| TW226375B (es) * | 1991-10-24 | 1994-07-11 | American Home Prod | |
| US5149699A (en) * | 1991-10-24 | 1992-09-22 | American Home Products Corporation | Substituted pyridopyrimidines useful as antgiotensin II antagonists |
| GB9125842D0 (en) * | 1991-12-04 | 1992-02-05 | Ici Plc | Heterocyclic derivatives |
-
1994
- 1994-03-16 DE DE69415706T patent/DE69415706T2/de not_active Expired - Fee Related
- 1994-03-16 ES ES94301881T patent/ES2126061T3/es not_active Expired - Lifetime
- 1994-03-16 SG SG1996004015A patent/SG47714A1/en unknown
- 1994-03-16 EP EP94301881A patent/EP0618207B1/en not_active Expired - Lifetime
- 1994-03-16 DK DK94301881T patent/DK0618207T3/da active
- 1994-03-16 AT AT94301881T patent/ATE175413T1/de not_active IP Right Cessation
- 1994-03-16 EP EP98105002A patent/EP0863143A1/en not_active Withdrawn
- 1994-03-21 FI FI941309A patent/FI108135B/fi active
- 1994-03-22 HU HU9400822A patent/HU222240B1/hu not_active IP Right Cessation
- 1994-03-23 CA CA002119692A patent/CA2119692A1/en not_active Abandoned
- 1994-03-23 JP JP6051645A patent/JPH06321945A/ja active Pending
- 1994-03-23 AU AU57997/94A patent/AU669966B2/en not_active Ceased
- 1994-03-23 BR BR9401261A patent/BR9401261A/pt not_active Application Discontinuation
- 1994-03-23 NZ NZ260164A patent/NZ260164A/en unknown
- 1994-03-23 PH PH47970A patent/PH30373A/en unknown
-
1999
- 1999-02-15 LV LVP-99-24A patent/LV12261B/en unknown
- 1999-04-05 GR GR990400968T patent/GR3029879T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3029879T3 (en) | 1999-07-30 |
| NZ260164A (en) | 1996-02-27 |
| AU669966B2 (en) | 1996-06-27 |
| LV12261B (en) | 1999-09-20 |
| HK1011358A1 (en) | 1999-07-09 |
| HU9400822D0 (en) | 1994-06-28 |
| EP0618207A1 (en) | 1994-10-05 |
| EP0618207B1 (en) | 1999-01-07 |
| FI941309A0 (fi) | 1994-03-21 |
| PH30373A (en) | 1997-04-02 |
| CA2119692A1 (en) | 1994-09-25 |
| LV12261A (lv) | 1999-04-20 |
| ATE175413T1 (de) | 1999-01-15 |
| DK0618207T3 (da) | 1999-08-30 |
| HUT66964A (en) | 1995-01-30 |
| DE69415706D1 (de) | 1999-02-18 |
| SG47714A1 (en) | 1998-04-17 |
| DE69415706T2 (de) | 1999-05-20 |
| FI108135B (fi) | 2001-11-30 |
| HU222240B1 (hu) | 2003-05-28 |
| FI941309L (fi) | 1994-09-25 |
| EP0863143A1 (en) | 1998-09-09 |
| JPH06321945A (ja) | 1994-11-22 |
| BR9401261A (pt) | 1994-11-22 |
| AU5799794A (en) | 1994-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ITMI921203A1 (it) | Derivati di s-triazina come agenti fotostabilizzanti | |
| AR029634A1 (es) | Compuestos derivados heterociclicos utiles como agentes anticancerosos, composicion farmaceutica y procedimiento de tratamiento | |
| LV12211A (lv) | Homoeritromicina-a atvasinajumi | |
| CO4230097A1 (es) | Piridopirimidinas sustituidas como antihipertensivos | |
| AR047076A1 (es) | Compuestos de pirrolotriazina como inhibidores de tirosina quinasas, composiciones farmaceuticas | |
| HUT61289A (en) | Process for producing pyrimidine derivatives of sulfonamides and pharmaceutical compositions comprising same | |
| AR011174A1 (es) | Compuestos de pirazina, composiciones farmaceuticas que los contienen, su uso en la peparacion de medicamentos y proceso para prepararlos | |
| PA8495101A1 (es) | Derivados de 13-metileritromicina | |
| CO4950563A1 (es) | Nuevos compuestos | |
| ES2051479T3 (es) | Uso de imidazoles substituidos en 4 para disminuir la presion intraocular. | |
| ES2106616T3 (es) | Derivados de 11,21-bisfenilo-19-nor-pregnanos. | |
| FR2695387B1 (fr) | Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| ES2084339T3 (es) | Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central. | |
| PT992509E (pt) | Novos derivados macrolidos | |
| AR007997A1 (es) | Un derivado de distamicina sustituida con acriloilo, sus utilizaciones, un procedimiento para producirlo y una composicion farmaceutica que lo comprende. | |
| ES2038074B1 (es) | Procedimiento para la preparacion de nuevos derivados de benzimidazol. | |
| AR018706A1 (es) | Uso de una composicion farmaceutica para tratamiento de infecciones virales | |
| CO4700291A1 (es) | Compuestos quimicos | |
| CO5011066A1 (es) | Compuestos de triazina | |
| KR910021374A (ko) | 헥사하이드로 벤즈[cd]인돌 | |
| SE9302333D0 (sv) | New compounds | |
| ES2126061T3 (es) | Piridopirimidinas substituidas como antihipertensores. | |
| ES2091283T3 (es) | Derivados de isocromano. | |
| FR2756826B1 (fr) | Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| ES2043515A1 (es) | Procedimiento para la preparacion de nuevos derivados de 1-difenilmetilpiperazina. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 618207 Country of ref document: ES |