ES2127384T3 - Parche de sustancia activa para la administracion de estradiol por la piel. - Google Patents

Parche de sustancia activa para la administracion de estradiol por la piel.

Info

Publication number
ES2127384T3
ES2127384T3 ES94909117T ES94909117T ES2127384T3 ES 2127384 T3 ES2127384 T3 ES 2127384T3 ES 94909117 T ES94909117 T ES 94909117T ES 94909117 T ES94909117 T ES 94909117T ES 2127384 T3 ES2127384 T3 ES 2127384T3
Authority
ES
Spain
Prior art keywords
active substance
estradiol
sub
skin
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909117T
Other languages
English (en)
Inventor
Teresa Maria Murphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Application granted granted Critical
Publication of ES2127384T3 publication Critical patent/ES2127384T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN EMPLASTO DE SUSTANCIA ACTIVA DISEÑADO PARA LA LIBERACION DE ESTRADIOL EN LA PIEL, SIENDO CARACTERIZADO POR MEDIO DEL HECHO DE QUE CONSISTE EN UNA PELICULA DE ADHERENCIA, DISPONIENDO DE UNA RESERVA DE SUSTANCIA ACTIVA UNIDA. LA SUSTANCIA ACTIVA ES AL MENOS PARCIALMENTE SOLUBLE Y PROVISTA CON UN ADHESIVO SENSIBLE A LA PRESION, MAS UNA CAPA LIBERABLE DE FORMA PROTECTIVA QUE CUBRE LA PELICULA ADHESIVA. LA RESERVA DE SUSTANCIA ACTIVA ES UNA MATRIZ DE POLIMERO A LA QUE SE AÑADE UN ACELERADOR DE PENETRACION DE LA FORMULA GENERAL (I), EN DONDE R = - CH{SUB,2}OH O - CH{SUB,2} - O - CH{SUB,2} CHOH CH{SUB,2}OH, PARA MEJORAR LA BIODISPONIBILIDAD DEL ESTRADIOL.
ES94909117T 1993-03-26 1994-03-07 Parche de sustancia activa para la administracion de estradiol por la piel. Expired - Lifetime ES2127384T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4309830A DE4309830C1 (de) 1993-03-26 1993-03-26 Wirkstoffpflaster für die Abgabe von Estradiol an die Haut

Publications (1)

Publication Number Publication Date
ES2127384T3 true ES2127384T3 (es) 1999-04-16

Family

ID=6483909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909117T Expired - Lifetime ES2127384T3 (es) 1993-03-26 1994-03-07 Parche de sustancia activa para la administracion de estradiol por la piel.

Country Status (23)

Country Link
US (1) US5686098A (es)
EP (1) EP0689458B1 (es)
JP (1) JPH08508266A (es)
KR (1) KR960700754A (es)
AT (1) ATE173636T1 (es)
AU (1) AU681383B2 (es)
CA (1) CA2156746A1 (es)
CZ (1) CZ287544B6 (es)
DE (2) DE4309830C1 (es)
DK (1) DK0689458T3 (es)
ES (1) ES2127384T3 (es)
FI (1) FI954497A7 (es)
GR (1) GR3029387T3 (es)
HR (1) HRP940213A2 (es)
HU (1) HU220861B1 (es)
IL (1) IL109084A (es)
NO (1) NO953792L (es)
NZ (1) NZ262418A (es)
PL (1) PL173547B1 (es)
SK (1) SK280246B6 (es)
WO (1) WO1994022481A1 (es)
YU (1) YU14394A (es)
ZA (1) ZA941987B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4429663C2 (de) * 1994-08-20 1997-09-11 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit Hydrolyseschutz
DE4429664C2 (de) * 1994-08-20 1997-09-11 Lohmann Therapie Syst Lts Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung
DE19526864A1 (de) * 1995-07-22 1997-01-23 Labtec Gmbh Hormonpflaster
FR2749586B1 (fr) * 1996-06-11 1998-08-07 Hoechst Marion Roussel Inc Nouveaux dispositifs destines a l'administration transdermique de la trimegestone, leur procede de preparation et leur application a titre de medicaments
DE19701949A1 (de) * 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermales therapeutisches System
DE19702314C2 (de) * 1997-01-23 2000-12-21 Lohmann Therapie Syst Lts Ablösbare Schutzfolie für wirkstoffhaltige, insbesondere selbstklebende Pflastersysteme
FR2776191B1 (fr) * 1998-03-23 2002-05-31 Theramex Composition hormonale topique a effet systemique
DE19828273B4 (de) * 1998-06-25 2005-02-24 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren
FR2789586A1 (fr) * 1999-02-16 2000-08-18 Synthelabo Composition pharmaceutique pour administration transmucosale balanique d'alfuzosine
DE10008128A1 (de) * 2000-02-22 2001-08-23 Bayer Ag Endoparasitizide Mittel
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
FR2869232B1 (fr) * 2004-04-21 2007-09-21 Gattefosse Sas Soc Par Actions Nouveaux excipients pharmaceutiques ou cosmetiques a base d'acetals cyliques
US20060134188A1 (en) * 2004-12-20 2006-06-22 Hans-Peter Podhaisky Transdermal pharmaceutical preparation with a progesterone A-specific ligand (PRASL) as active ingredient
DE102004062182B4 (de) * 2004-12-20 2007-06-06 Bayer Schering Pharma Ag Transdermales Pflaster mit Progesteron A-Spezifische Liganden (PRASL) als Wirkstoff
FR2912149B1 (fr) * 2007-02-05 2012-10-12 Rhodia Poliamida E Especialidades Ltda Utilisation de derives de dioxolane dans des systemes de revetement et formulation de systeme de revetement
JP5358574B2 (ja) * 2007-08-17 2013-12-04 アルション セラピューティクス， インコーポレイテッド 高濃度の局所麻酔薬調合物
DE102008059054A1 (de) * 2008-11-26 2010-05-27 Otto Bock Pur Life Science Gmbh Polyurethanpflaster für die transdermale Applikation von Wirkstoffen und Verfahren zu dessen Herstellung
JP5576523B2 (ja) * 2013-02-22 2014-08-20 ロディア・ポリアミダ・エ・エスペシアリダデス・リミターダ コーティング系におけるジオキソラン誘導体の使用及びコーティング系配合物
JP5639208B2 (ja) * 2013-02-22 2014-12-10 ロディア・ポリアミダ・エ・エスペシアリダデス・リミターダＲｈｏｄｉａ Ｐｏｌｉａｍｉｄａ Ｅ Ｅｓｐｅｃｉａｌｉｄａｄｅｓ Ｌｔｄａ コーティング系におけるジオキソラン誘導体の使用及びコーティング系配合物
JP7429795B2 (ja) * 2020-08-26 2024-02-08 中国塗料株式会社 低ｖｏｃ塗料組成物、塗膜および塗膜付き基材ならびにこれらの製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1385914A (en) * 1971-10-19 1975-03-05 Wigglesworth Ltd Compositions having bactericidal activity
BE795226A (fr) * 1972-02-11 1973-08-09 Syntex Corp Vehicule pour pommade contenant du dimethyl-2,2dioxolane-1,3 methanol-4
US4818540A (en) * 1985-02-25 1989-04-04 Rutgers, The State University Of New Jersey Transdermal fertility control system and process
US4906169A (en) * 1986-12-29 1990-03-06 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US5023084A (en) * 1986-12-29 1991-06-11 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
ES2062093T3 (es) * 1988-08-02 1994-12-16 Ciba Geigy Ag Emplasto de varias capas.
AU6712090A (en) * 1989-10-13 1991-05-16 Watson Laboratories, Inc. Drug delivery systems and matrix therefor
SE8904296D0 (sv) * 1989-12-21 1989-12-21 Pharmacia Ab Transdermal system

Also Published As

Publication number Publication date
AU6208394A (en) 1994-10-24
HU220861B1 (en) 2002-06-29
YU14394A (sh) 1997-01-08
EP0689458A1 (de) 1996-01-03
US5686098A (en) 1997-11-11
SK120695A3 (en) 1997-02-05
FI954497L (fi) 1995-09-22
PL310555A1 (en) 1995-12-27
NO953792D0 (no) 1995-09-25
ZA941987B (en) 1995-04-05
DE4309830C1 (de) 1994-05-05
ATE173636T1 (de) 1998-12-15
CZ248995A3 (en) 1996-03-13
KR960700754A (ko) 1996-02-24
PL173547B1 (pl) 1998-03-31
NO953792L (no) 1995-09-25
HUT73425A (en) 1996-07-29
DE59407345D1 (de) 1999-01-07
HU9502794D0 (en) 1995-11-28
AU681383B2 (en) 1997-08-28
GR3029387T3 (en) 1999-05-28
JPH08508266A (ja) 1996-09-03
CZ287544B6 (en) 2000-12-13
CA2156746A1 (en) 1994-10-13
IL109084A0 (en) 1994-06-24
WO1994022481A1 (de) 1994-10-13
DK0689458T3 (da) 1999-08-09
IL109084A (en) 1996-12-05
SK280246B6 (sk) 1999-10-08
NZ262418A (en) 1996-08-27
FI954497A0 (fi) 1995-09-22
FI954497A7 (fi) 1995-09-22
EP0689458B1 (de) 1998-11-25
HRP940213A2 (en) 1998-02-28

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