ES2127563T3 - Ensayo de bloqueo de plaquetas. - Google Patents

Ensayo de bloqueo de plaquetas.

Info

Publication number
ES2127563T3
ES2127563T3 ES95935026T ES95935026T ES2127563T3 ES 2127563 T3 ES2127563 T3 ES 2127563T3 ES 95935026 T ES95935026 T ES 95935026T ES 95935026 T ES95935026 T ES 95935026T ES 2127563 T3 ES2127563 T3 ES 2127563T3
Authority
ES
Spain
Prior art keywords
iib
iiia
beds
agglutination
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95935026T
Other languages
English (en)
Inventor
Barry S Coller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icahn School of Medicine at Mount Sinai
Original Assignee
Mount Sinai School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mount Sinai School of Medicine filed Critical Mount Sinai School of Medicine
Application granted granted Critical
Publication of ES2127563T3 publication Critical patent/ES2127563T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION ES UN ENSAYO PARA DETERMINAR UNA OBSTRUCCION DE RECEPTORES IIB/IIIA DE GLICOPROTEINA EN SANGRE ENTERA. LA AGLUTINACION DE CAMAS POLIMERICAS PEQUE¥AS REVESTIDAS CON UN LIGANTE IIB/IIIA DE GLICOPROTEINA COMO, POR EJEMPLO, FIBRINOGEN, SE OBTIENE CUANDO LAS CAMAS ESTAN CONECTADAS CON LA SANGRE ENTERA QUE CONTIENE PLAQUETAS CON RECEPTORES DE GLICOPROTEINA QUE NO ESTAN BLOQUEADOS. EL FALLO EN LA AGLUTINACION INDICA QUE LA OBSTRUCCION DE LOS RECEPTORES GPIIB/IIA SE HA ALCANZADO. EN EL MODELO PREFERIDO, LA ADICION DE UN ACTIVADOR DE UN RECEPTOR DE TROMBINA DA COMO RESULTADO UN ENSAYO QUE ES LO SUFICIENTEMENTE RAPIDO Y CONVENIENTE PARA SER LLEVADO A CABO A PARTE, Y DA COMO RESULTADO LA AGLUTINACION DE CAMAS POLIMERICAS PEQUE¥AS DENTRO DE UN PERIODO DE TIEMPO CONVENIENTE CONOCIDO SI LOS RECEPTORES IIB/IIIA DE GLICOPROTEINAS NO ESTAN BLOQUEADOS.
ES95935026T 1994-09-29 1995-09-20 Ensayo de bloqueo de plaquetas. Expired - Lifetime ES2127563T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/315,026 US5763199A (en) 1994-09-29 1994-09-29 Platelet blockade assay

Publications (1)

Publication Number Publication Date
ES2127563T3 true ES2127563T3 (es) 1999-04-16

Family

ID=23222552

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95935026T Expired - Lifetime ES2127563T3 (es) 1994-09-29 1995-09-20 Ensayo de bloqueo de plaquetas.

Country Status (12)

Country Link
US (2) US5763199A (es)
EP (1) EP0783696B1 (es)
JP (1) JPH10506988A (es)
AT (1) ATE174122T1 (es)
AU (1) AU3720095A (es)
CA (1) CA2201283C (es)
DE (1) DE69506434T2 (es)
DK (1) DK0783696T3 (es)
ES (1) ES2127563T3 (es)
GR (1) GR3029470T3 (es)
IL (1) IL115431A (es)
WO (1) WO1996010749A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19620443C2 (de) 1996-05-21 1998-09-17 Rhein Biotech Proz & Prod Gmbh Verfahren zum automatischen Durchführen von Bluttests
US5922551A (en) * 1997-03-20 1999-07-13 Accumetrics, Inc. Agglutrimetric platelet binding assays in blood
EP0983509B1 (en) * 1997-05-14 2005-08-17 Biosite Diagnostics Inc. Rapid evaluation of the ratio of biological molecules
FR2764388B1 (fr) * 1997-06-06 1999-08-27 Biocytex Nouvelle methode d'analyse des recepteurs plaquettaires gpiib/iiia
DE19836559A1 (de) * 1998-08-12 2000-03-23 Antigen Gmbh Gefäß zur Entnahme von Blut
AU1218900A (en) * 1998-10-23 2000-05-15 Accumetrics, Inc. Method for determining platelet count
DE69941031D1 (de) * 1998-11-12 2009-08-06 Novolytics Inc Zusammensetzungen und verfahren zur erzeugung von gefässeokklusion
AU5044400A (en) * 1999-05-28 2000-12-18 Sendx Medical, Inc. Control for methods for determining platelet count and platelet function
US20040001826A1 (en) * 1999-06-30 2004-01-01 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US6245527B1 (en) 1999-06-30 2001-06-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US6586259B1 (en) * 1999-11-15 2003-07-01 Pharmanetics Incorporated Platelet/leukocyte interaction assay and reagent therefor
US6699677B1 (en) 1999-12-20 2004-03-02 Chemocentryx, Inc. Tethered ligands and methods of use
JP4643783B2 (ja) * 1999-12-24 2011-03-02 一般財団法人化学及血清療法研究所 フォンヴィルブランド因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物
DE10013377A1 (de) * 2000-03-17 2001-09-20 Dade Behring Marburg Gmbh Induzierte Aggregation und Agglutination von Plättchen
CN1317394C (zh) * 2000-06-12 2007-05-23 希森美康株式会社 免疫测定方法和免疫测定装置
DE10038900A1 (de) * 2000-08-09 2002-03-07 Haemosys Gmbh Einfache Methode zum drug monitoring von GPIIb/IIIa-Rezeptor-Antagonisten
EP1370874A2 (en) * 2001-01-24 2003-12-17 Accumetrics, Inc. Methods for determining platelet activity with antiplatelet compositions
US6746872B2 (en) * 2002-01-16 2004-06-08 Lifescan, Inc. Control compositions and methods of use for coagulation tests
US20040131500A1 (en) * 2002-01-18 2004-07-08 Chow Herbert S. Device and method for evaluating platelets
ATE491945T1 (de) * 2003-05-12 2011-01-15 Ulrich Pachmann Verfahren zur bestimmung des vorhandenseins von thrombozyteninhibitoren in einer blutprobe
ATE536889T1 (de) 2003-07-08 2011-12-15 Accumetrics Inc Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten
US20070243632A1 (en) * 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
JP2008512098A (ja) 2004-09-07 2008-04-24 アーケミックス コーポレイション フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用
JP2008512097A (ja) 2004-09-07 2008-04-24 アーケミックス コーポレイション アプタマー医薬品化学
US7566701B2 (en) 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
US7595169B2 (en) * 2005-04-27 2009-09-29 Accumetrics, Inc. Method for determining percent platelet aggregation
US7205115B2 (en) * 2005-04-28 2007-04-17 Accumetrics, Inc. Method and system for stabilization of arachidonic acid for use in platelet function assay
US8066961B2 (en) * 2005-07-20 2011-11-29 Corning Incorporated Kinematic wellplate mounting method
CA2636265C (en) 2006-01-03 2016-07-12 Rallybio Ipa, Llc Preparation useful for, and method for treatment of neonatal alloimmune thrombocytopenia (nait)
CA2686816A1 (en) 2007-01-16 2008-07-24 The Johns Hopkins University Use of various glutamate receptor antagonists for delaying or preventing platelet activity or for treating or preventing a thrombotic disease or disorder
KR20100017576A (ko) * 2007-05-03 2010-02-16 아큐메트릭스, 인크. 트롬빈 수용체 길항제에 의한 혈소판 응집 억제의 측정 방법
WO2009152094A2 (en) * 2008-06-09 2009-12-17 Accumetrics, Inc. Hubbed dual cannula device for closed container sampling systems
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
US20110165595A1 (en) * 2009-07-13 2011-07-07 Catanzaro Brian E Apparatus and methods for processing a whole blood sample
US10816559B2 (en) 2014-09-29 2020-10-27 Ca Casyso Ag Blood testing system and method
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
CN105717263B (zh) * 2016-03-04 2018-01-26 北京乐普医疗科技有限责任公司 一种检测噻吩并吡啶类抗血小板药物疗效的试剂卡及其使用方法和应用
ES2862434T3 (es) * 2017-08-02 2021-10-07 Siemens Healthcare Diagnostics Products Gmbh Prueba de unión para el diagnóstico de trombocitopenia inducida por heparina
CN114599973B (zh) * 2019-10-17 2026-02-13 诺尔生物医药有限公司 凝血测定装置及其方法
US12543980B2 (en) 2021-06-21 2026-02-10 Instrumentation Laboratory Company Determining a platelet aggregation value
CN114720705A (zh) * 2022-04-20 2022-07-08 中国科学院苏州生物医学工程技术研究所 基于微球的血小板聚集功能检测质控品及质控方法
CN119291207B (zh) * 2024-08-30 2026-04-17 北京睿瑧生物技术有限公司 一种用于测定血小板数量的组合物、装置及检测方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717654A (en) * 1984-06-19 1988-01-05 Akzo N.V. Process for solid phase platelet antibody assay
US5275812A (en) * 1985-06-07 1994-01-04 The General Hospital Corporation Method of treatment for myocardial infarction
US5114842A (en) * 1987-07-08 1992-05-19 The Scripps Research Institute Peptides and antibodies that inhibit platelet adhesion
ATE119170T1 (de) * 1988-11-23 1995-03-15 Cytec Tech Corp Poröse oberflächen-hydratisierte substrate aus polyacrylnitril, wie perlderivate, verfahren zu deren herstellung und verfahren zur verwendung.
CA2016061A1 (en) * 1989-05-08 1990-11-08 Laurence Wu-Kwang Chang Surface modified polyacrylonitrile substrates
US5246832A (en) * 1990-06-20 1993-09-21 University Of Massachusetts Medical Center Platelet analysis in whole blood
US5196309A (en) * 1990-11-15 1993-03-23 The Scripps Research Institute Characterization of platelet aggregation disorders
US5266462A (en) * 1992-06-03 1993-11-30 Baxter Diagnostics Inc. Measurement of platelet activities
US5427913A (en) * 1992-12-03 1995-06-27 Alberta Cancer Board Methods for determining platelet function
GB9306053D0 (en) * 1993-03-24 1993-05-12 Nycomed Pharma As Method and assay
US5455228A (en) * 1993-07-02 1995-10-03 The Research Foundation Of State University Of New York Peptidase resistant thrombin receptor peptide ligand
IL106330A (en) * 1993-07-14 1998-01-04 Univ Ramot Method and instrument for determining the activity of their plaques in the initial coagulation system
US5455288A (en) * 1994-01-26 1995-10-03 Needham; Donald G. Dustless color concentrate granules
WO1995027209A1 (en) * 1994-03-31 1995-10-12 The Trustees Of The University Of Pennsylvania Method and kit for detection of thrombin receptor activation of platelets and other cells

Also Published As

Publication number Publication date
DE69506434T2 (de) 1999-06-10
DK0783696T3 (da) 1999-08-16
CA2201283A1 (en) 1996-04-11
EP0783696B1 (en) 1998-12-02
CA2201283C (en) 2004-05-18
US5854005A (en) 1998-12-29
JPH10506988A (ja) 1998-07-07
ATE174122T1 (de) 1998-12-15
EP0783696A1 (en) 1997-07-16
GR3029470T3 (en) 1999-05-28
IL115431A0 (en) 1996-01-31
AU3720095A (en) 1996-04-26
IL115431A (en) 1999-10-28
US5763199A (en) 1998-06-09
DE69506434D1 (de) 1999-01-14
WO1996010749A1 (en) 1996-04-11

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