ES2128043T3 - Uso de bis(amidinobencimidazoles) en la preparacion de un medicamento para inhibir la integrasa retroviral. - Google Patents
Uso de bis(amidinobencimidazoles) en la preparacion de un medicamento para inhibir la integrasa retroviral.Info
- Publication number
- ES2128043T3 ES2128043T3 ES95908504T ES95908504T ES2128043T3 ES 2128043 T3 ES2128043 T3 ES 2128043T3 ES 95908504 T ES95908504 T ES 95908504T ES 95908504 T ES95908504 T ES 95908504T ES 2128043 T3 ES2128043 T3 ES 2128043T3
- Authority
- ES
- Spain
- Prior art keywords
- bis
- amidinobencimidazoles
- preparation
- retroviral integrase
- medicinal product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102100034343 Integrase Human genes 0.000 abstract 2
- 108010061833 Integrases Proteins 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000001177 retroviral effect Effects 0.000 abstract 2
- QZKOOEFIMWKZPK-UHFFFAOYSA-N 2-[(6-carbamimidoyl-1h-benzimidazol-2-yl)methyl]-3h-benzimidazole-5-carboximidamide Chemical compound C1=C(C(N)=N)C=C2NC(CC3=NC4=CC=C(C=C4N3)C(=N)N)=NC2=C1 QZKOOEFIMWKZPK-UHFFFAOYSA-N 0.000 abstract 1
- DFFCDIMSXJYMTB-UHFFFAOYSA-N 2-[2-(6-carbamimidoyl-1h-benzimidazol-2-yl)ethenyl]-3h-benzimidazole-5-carboximidamide Chemical compound C1=C(C(N)=N)C=C2NC(C=CC3=NC4=CC=C(C=C4N3)C(=N)N)=NC2=C1 DFFCDIMSXJYMTB-UHFFFAOYSA-N 0.000 abstract 1
- KIYLEUCIWFUYOC-UHFFFAOYSA-N 2-[2-(6-carbamimidoyl-1h-benzimidazol-2-yl)ethyl]-3h-benzimidazole-5-carboximidamide Chemical compound C1=C(C(N)=N)C=C2NC(CCC3=NC4=CC=C(C=C4N3)C(=N)N)=NC2=C1 KIYLEUCIWFUYOC-UHFFFAOYSA-N 0.000 abstract 1
- 206010038997 Retroviral infections Diseases 0.000 abstract 1
- -1 bis-benzimidazole compound Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thin Film Transistor (AREA)
- Saccharide Compounds (AREA)
- Recrystallisation Techniques (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
Abstract
SE PRESENTA UN METODO PARA INHIBIR LA INTEGRASA RETROVIRAL EN UN SUJETO EN NECESIDAD DEL TRATAMIENTO. EL METODO COMPRENDE LA ADMINISTRACION AL SUJETO DE UNA CANTIDAD INHIBIDORA DE LA INTEGRASA RETROVIRAL DE UN COMPUESTO DE BIS-BENCIMIDAZOLA, TAL COMO BIS[5-AMIDINO-2-5-BENZIMIDAZOLIL]METANO, 1,2-BIS[5-AMIDINO2-BENZIMIDAZOLIL]ETANO, 1,2-BIS[5-AMIDINO-2-BENZIMIDAZOLIL]ETANO O UNA SAL FARMACOLOGICAMENTE ACEPTABLE DE LOS MISMOS. TAMBIEN SE PRESENTA UN METODO PARA COMBATIR LAS INFECCIONES RETROVIRALES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/185,079 US6815461B1 (en) | 1994-01-20 | 1994-01-20 | Method of inhibiting retroviral integrase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2128043T3 true ES2128043T3 (es) | 1999-05-01 |
Family
ID=22679488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95908504T Expired - Lifetime ES2128043T3 (es) | 1994-01-20 | 1995-01-18 | Uso de bis(amidinobencimidazoles) en la preparacion de un medicamento para inhibir la integrasa retroviral. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6815461B1 (es) |
| EP (1) | EP0739202B1 (es) |
| JP (1) | JP3306830B2 (es) |
| AT (1) | ATE174508T1 (es) |
| AU (1) | AU675386B2 (es) |
| BR (1) | BR9506552A (es) |
| CA (1) | CA2179015C (es) |
| DE (1) | DE69506686T2 (es) |
| ES (1) | ES2128043T3 (es) |
| NZ (2) | NZ279619A (es) |
| WO (1) | WO1995019772A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562854B2 (en) | 1994-12-14 | 2003-05-13 | Axys Pharmaceuticals, Inc. | Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders |
| US6255091B1 (en) | 1995-04-28 | 2001-07-03 | Axys Pharmaceuticals, Inc. | Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions |
| US5693515A (en) * | 1995-04-28 | 1997-12-02 | Arris Pharmaceutical Corporation | Metal complexed serine protease inhibitors |
| EP0963371B1 (en) | 1997-02-25 | 2003-05-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase |
| US5935982A (en) * | 1997-02-28 | 1999-08-10 | The University Of North Carolina At Chapel Hill | Methods of treating retroviral infection and compounds useful therefor |
| JP2001519806A (ja) * | 1997-04-07 | 2001-10-23 | アクシス ファーマシューティカルズ，インコーポレイティド | セリンプロテアーゼ活性、特にトリプターゼ活性に関連する疾病を処理するための化合物及び組成物 |
| FR2766822B1 (fr) * | 1997-07-30 | 2001-02-23 | Adir | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6150379A (en) * | 1997-11-26 | 2000-11-21 | Axys Pharmaceuticals, Inc. | Compounds and compositions as anticoagulants |
| AU1608399A (en) * | 1997-11-26 | 1999-06-15 | Axys Pharmaceuticals, Inc. | Substituted amidinoaryl derivatives and their use as anticoagulants |
| PL343424A1 (en) | 1998-04-10 | 2001-08-13 | Japan Tobacco Inc | Amidine compounds |
| JP4562290B2 (ja) | 1999-05-13 | 2010-10-13 | 独立行政法人科学技術振興機構 | インテグラーゼｎ−末端領域を標的としたウイルス感染阻害剤 |
| DE60007310D1 (de) * | 1999-06-04 | 2004-01-29 | Elan Pharma Int Ltd | Zusammensetzungen und methoden zur verhinderung des zelltods |
| WO2001032159A2 (en) * | 1999-11-01 | 2001-05-10 | The University Of North Carolina At Chapel Hill | Methods and formulations for the treatment of infectious bursal disease in avian subjects |
| US6774144B1 (en) | 1999-11-01 | 2004-08-10 | The University Of North Carolina At Chapel Hill | Methods and formulations for the treatment of infectious bursal disease in avian subjects |
| US7262223B2 (en) | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| EP2120952A4 (en) * | 2007-01-15 | 2011-09-21 | Us Of America As Represented By The Secretary Of The Army On Behalf Of The U S Army Res Inst Of Infe | ANTIVIRAL COMPOUNDS AND METHODS OF USE |
| RU2010120686A (ru) * | 2007-10-24 | 2011-11-27 | Фанкшенл Дженетикс,Инк. (Us) | Способы ингибирования вирусной инфекции |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA708089B (en) * | 1969-12-29 | 1971-08-25 | Abbott Lab | Bis-benzimidazole derivatives |
| US4619942A (en) * | 1982-04-08 | 1986-10-28 | University Of North Carolina | Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds |
| US4933347A (en) | 1988-10-25 | 1990-06-12 | University Of North Carolina At Chapel Hill | Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia |
| US4963589A (en) | 1988-10-25 | 1990-10-16 | The University Of North Carolina At Chapel Hill | Methods for treating Giardia lamblia |
| US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
| JPH09506335A (ja) | 1993-09-22 | 1997-06-24 | ザ、ウェルカム、ファンデーション、リミテッド | 抗ウイルス剤としてのビス（アミノベンズイミダゾリル）アルカン |
-
1994
- 1994-01-20 US US08/185,079 patent/US6815461B1/en not_active Expired - Fee Related
-
1995
- 1995-01-18 NZ NZ279619A patent/NZ279619A/en unknown
- 1995-01-18 NZ NZ335226A patent/NZ335226A/xx unknown
- 1995-01-18 EP EP95908504A patent/EP0739202B1/en not_active Expired - Lifetime
- 1995-01-18 AU AU16798/95A patent/AU675386B2/en not_active Ceased
- 1995-01-18 DE DE69506686T patent/DE69506686T2/de not_active Expired - Fee Related
- 1995-01-18 JP JP51960295A patent/JP3306830B2/ja not_active Expired - Fee Related
- 1995-01-18 ES ES95908504T patent/ES2128043T3/es not_active Expired - Lifetime
- 1995-01-18 BR BR9506552A patent/BR9506552A/pt not_active Application Discontinuation
- 1995-01-18 AT AT95908504T patent/ATE174508T1/de not_active IP Right Cessation
- 1995-01-18 WO PCT/US1995/000504 patent/WO1995019772A1/en not_active Ceased
- 1995-01-18 CA CA002179015A patent/CA2179015C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0739202B1 (en) | 1998-12-16 |
| AU1679895A (en) | 1995-08-08 |
| WO1995019772A1 (en) | 1995-07-27 |
| AU675386B2 (en) | 1997-01-30 |
| DE69506686T2 (de) | 1999-07-22 |
| NZ279619A (en) | 1999-09-29 |
| CA2179015C (en) | 2003-06-24 |
| JP3306830B2 (ja) | 2002-07-24 |
| ATE174508T1 (de) | 1999-01-15 |
| EP0739202A1 (en) | 1996-10-30 |
| DE69506686D1 (de) | 1999-01-28 |
| NZ335226A (en) | 2000-11-24 |
| JPH09508369A (ja) | 1997-08-26 |
| CA2179015A1 (en) | 1995-07-27 |
| US6815461B1 (en) | 2004-11-09 |
| BR9506552A (pt) | 1997-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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