ES2128592T3 - Procedimiento para preparar terc-leucina y analogos de la misma en forma enantiomerica y productos intermedios. - Google Patents

Procedimiento para preparar terc-leucina y analogos de la misma en forma enantiomerica y productos intermedios.

Info

Publication number
ES2128592T3
ES2128592T3 ES94931136T ES94931136T ES2128592T3 ES 2128592 T3 ES2128592 T3 ES 2128592T3 ES 94931136 T ES94931136 T ES 94931136T ES 94931136 T ES94931136 T ES 94931136T ES 2128592 T3 ES2128592 T3 ES 2128592T3
Authority
ES
Spain
Prior art keywords
enantiomerical
leucine
analogs
preparing
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94931136T
Other languages
English (en)
Spanish (es)
Inventor
Nicholas Turner
James Winterman
Raymond Mccague
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chirotech Technology Ltd
Original Assignee
Chirotech Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chirotech Technology Ltd filed Critical Chirotech Technology Ltd
Application granted granted Critical
Publication of ES2128592T3 publication Critical patent/ES2128592T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/42—One oxygen atom attached in position 5
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
ES94931136T 1993-11-01 1994-11-01 Procedimiento para preparar terc-leucina y analogos de la misma en forma enantiomerica y productos intermedios. Expired - Lifetime ES2128592T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939322472A GB9322472D0 (en) 1993-11-01 1993-11-01 Chiral compounds and their preparation

Publications (1)

Publication Number Publication Date
ES2128592T3 true ES2128592T3 (es) 1999-05-16

Family

ID=10744442

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94931136T Expired - Lifetime ES2128592T3 (es) 1993-11-01 1994-11-01 Procedimiento para preparar terc-leucina y analogos de la misma en forma enantiomerica y productos intermedios.

Country Status (10)

Country Link
US (1) US6180374B1 (de)
EP (1) EP0726891B1 (de)
JP (1) JPH09504304A (de)
AT (1) ATE176461T1 (de)
AU (1) AU676786B2 (de)
CA (1) CA2173205A1 (de)
DE (1) DE69416424T2 (de)
ES (1) ES2128592T3 (de)
GB (1) GB9322472D0 (de)
WO (1) WO1995012573A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19529211C2 (de) * 1995-08-09 1999-01-14 Degussa Verfahren zur Herstellung von (R)-tertiär-Leucin
BR9708425B1 (pt) * 1996-04-02 2012-02-22 fenilcetoenóis substituìdos, processo para preparação e uso dos mesmos, bem como pesticidas ou herbicidas e método para controle de pragas e ervas daninhas.
GB9607458D0 (en) 1996-04-10 1996-06-12 Zeneca Ltd Enzymatic process for stereoselective preparation of therapeutic amides
US6130337A (en) * 1997-04-11 2000-10-10 Board Of Trustees Of Leland Stanford Junior University Enantiomerically enriched α,α-distributed amino acids and method
JP2000319241A (ja) * 1999-04-28 2000-11-21 Ihara Chem Ind Co Ltd フェニルアルカン酸アミド化合物の製造方法
WO2009063804A1 (ja) 2007-11-16 2009-05-22 Kaneka Corporation Ｎ－カルバモイル－ｔｅｒｔ－ロイシンの製造法
CN104651381A (zh) 2008-01-03 2015-05-27 巴斯夫酶有限责任公司 转移酶和氧化还原酶、编码它们的核酸以及其制备和应用方法
EP2423187A4 (de) 2009-04-24 2015-08-12 Kaneka Corp Verfahren zur herstellung von n-alkoxycarbonyl-tert.-leucinen
US8835676B2 (en) 2011-03-21 2014-09-16 Divi's Laboratories Ltd. Process for the preparation of enantiomerically pure tert-leucine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219731A (en) * 1991-11-01 1993-06-15 Wisconsin Alumni Research Foundation Method for preparing optically-active amino acid derivatives
US5541080A (en) 1991-11-01 1996-07-30 Wisconsin Alumni Research Fdn. Method for preparing L-alpha-amino acids

Also Published As

Publication number Publication date
US6180374B1 (en) 2001-01-30
AU676786B2 (en) 1997-03-20
JPH09504304A (ja) 1997-04-28
GB9322472D0 (en) 1993-12-22
DE69416424T2 (de) 1999-06-10
EP0726891B1 (de) 1999-02-03
EP0726891A1 (de) 1996-08-21
CA2173205A1 (en) 1995-05-11
WO1995012573A1 (en) 1995-05-11
DE69416424D1 (de) 1999-03-18
AU8001294A (en) 1995-05-23
ATE176461T1 (de) 1999-02-15

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