ATE176461T1 - Verfahren zur herstellung von tert-leucin und analoge in enantiemerer form und zwischenprodukte - Google Patents
Verfahren zur herstellung von tert-leucin und analoge in enantiemerer form und zwischenprodukteInfo
- Publication number
- ATE176461T1 ATE176461T1 AT94931136T AT94931136T ATE176461T1 AT E176461 T1 ATE176461 T1 AT E176461T1 AT 94931136 T AT94931136 T AT 94931136T AT 94931136 T AT94931136 T AT 94931136T AT E176461 T1 ATE176461 T1 AT E176461T1
- Authority
- AT
- Austria
- Prior art keywords
- enantiemeric
- analogues
- leucine
- amino acid
- intermediate products
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- IEJPPSMHUUQABK-UHFFFAOYSA-N 2,4-diphenyl-4h-1,3-oxazol-5-one Chemical compound O=C1OC(C=2C=CC=CC=2)=NC1C1=CC=CC=C1 IEJPPSMHUUQABK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000036983 biotransformation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/42—One oxygen atom attached in position 5
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939322472A GB9322472D0 (en) | 1993-11-01 | 1993-11-01 | Chiral compounds and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE176461T1 true ATE176461T1 (de) | 1999-02-15 |
Family
ID=10744442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94931136T ATE176461T1 (de) | 1993-11-01 | 1994-11-01 | Verfahren zur herstellung von tert-leucin und analoge in enantiemerer form und zwischenprodukte |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6180374B1 (de) |
| EP (1) | EP0726891B1 (de) |
| JP (1) | JPH09504304A (de) |
| AT (1) | ATE176461T1 (de) |
| AU (1) | AU676786B2 (de) |
| CA (1) | CA2173205A1 (de) |
| DE (1) | DE69416424T2 (de) |
| ES (1) | ES2128592T3 (de) |
| GB (1) | GB9322472D0 (de) |
| WO (1) | WO1995012573A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19529211C2 (de) * | 1995-08-09 | 1999-01-14 | Degussa | Verfahren zur Herstellung von (R)-tertiär-Leucin |
| CA2250417A1 (en) * | 1996-04-02 | 1997-10-09 | Bayer Aktiengesellschaft | Substituted phenyl keto enols as pesticides and herbicides |
| GB9607458D0 (en) * | 1996-04-10 | 1996-06-12 | Zeneca Ltd | Enzymatic process for stereoselective preparation of therapeutic amides |
| US6130337A (en) * | 1997-04-11 | 2000-10-10 | Board Of Trustees Of Leland Stanford Junior University | Enantiomerically enriched α,α-distributed amino acids and method |
| JP2000319241A (ja) * | 1999-04-28 | 2000-11-21 | Ihara Chem Ind Co Ltd | フェニルアルカン酸アミド化合物の製造方法 |
| WO2009063804A1 (ja) | 2007-11-16 | 2009-05-22 | Kaneka Corporation | Ｎ－カルバモイル－ｔｅｒｔ－ロイシンの製造法 |
| EP2238242B9 (de) | 2008-01-03 | 2015-06-10 | BASF Enzymes LLC | Transferasen und oxidoreduktasen, dafür kodierende nukleinsäuren sowie verfahren zu ihrer herstellung und verwendung |
| KR20120026024A (ko) | 2009-04-24 | 2012-03-16 | 가부시키가이샤 가네카 | Ｎ-알콕시카르보닐-ｔｅｒｔ-류신의 제조법 |
| US8835676B2 (en) | 2011-03-21 | 2014-09-16 | Divi's Laboratories Ltd. | Process for the preparation of enantiomerically pure tert-leucine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541080A (en) | 1991-11-01 | 1996-07-30 | Wisconsin Alumni Research Fdn. | Method for preparing L-alpha-amino acids |
| US5219731A (en) * | 1991-11-01 | 1993-06-15 | Wisconsin Alumni Research Foundation | Method for preparing optically-active amino acid derivatives |
-
1993
- 1993-11-01 GB GB939322472A patent/GB9322472D0/en active Pending
-
1994
- 1994-11-01 AT AT94931136T patent/ATE176461T1/de not_active IP Right Cessation
- 1994-11-01 ES ES94931136T patent/ES2128592T3/es not_active Expired - Lifetime
- 1994-11-01 JP JP7513079A patent/JPH09504304A/ja active Pending
- 1994-11-01 WO PCT/GB1994/002392 patent/WO1995012573A1/en not_active Ceased
- 1994-11-01 EP EP94931136A patent/EP0726891B1/de not_active Expired - Lifetime
- 1994-11-01 CA CA002173205A patent/CA2173205A1/en not_active Abandoned
- 1994-11-01 AU AU80012/94A patent/AU676786B2/en not_active Ceased
- 1994-11-01 DE DE69416424T patent/DE69416424T2/de not_active Expired - Fee Related
-
1998
- 1998-08-10 US US09/131,466 patent/US6180374B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU676786B2 (en) | 1997-03-20 |
| DE69416424D1 (de) | 1999-03-18 |
| ES2128592T3 (es) | 1999-05-16 |
| GB9322472D0 (en) | 1993-12-22 |
| CA2173205A1 (en) | 1995-05-11 |
| EP0726891A1 (de) | 1996-08-21 |
| EP0726891B1 (de) | 1999-02-03 |
| JPH09504304A (ja) | 1997-04-28 |
| DE69416424T2 (de) | 1999-06-10 |
| WO1995012573A1 (en) | 1995-05-11 |
| US6180374B1 (en) | 2001-01-30 |
| AU8001294A (en) | 1995-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |