ES2129392T3 - Derivados de di-lisogangliosidos. - Google Patents

Derivados de di-lisogangliosidos.

Info

Publication number
ES2129392T3
ES2129392T3 ES90402141T ES90402141T ES2129392T3 ES 2129392 T3 ES2129392 T3 ES 2129392T3 ES 90402141 T ES90402141 T ES 90402141T ES 90402141 T ES90402141 T ES 90402141T ES 2129392 T3 ES2129392 T3 ES 2129392T3
Authority
ES
Spain
Prior art keywords
present
lisogangliosidos
derivatives
acil
lisogangliosid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90402141T
Other languages
English (en)
Inventor
Valle Francesco Della
Aurelio Romeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of ES2129392T3 publication Critical patent/ES2129392T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PRESENTAN N-ACIL-N,N''-DI-LISOGANGLIOSIDOS Y N,N''-DIACIL-N,N'' AN DE UN ACIDO ALIFATICO QUE TIENEN ENTRE 1 Y 24 ATOMOS DE CARBONO SUBSITUIDOS POR UNO O MAS GRUPOS POLARES. LOS ACIL LISOGANGLIOSIDOS DEL PRESENTE INVENTO EXHIBEN UNA ACCION INHIBIDORA SOBRE LA ACTIVACION DE LA PROTEINA KINASA C, Y DE ESTA FORMA, PUEDEN UTILIZARSE EN TERAPIAS PARA VARIAS PATOLOGIAS DEL SISTEMA NERVIOSO. TAMBIEN SE PRESENTAN COMPOSICIONES FARMACEUTICAS Y UTILIDADES TERAPEUTICAS PARA LOS DERIVADOS LISOGANGLIOSIDOS DEL PRESENTE INVENTO.
ES90402141T 1989-07-27 1990-07-25 Derivados de di-lisogangliosidos. Expired - Lifetime ES2129392T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8948247A IT1232176B (it) 1989-07-27 1989-07-27 Derivati di-lisogangliosidi

Publications (1)

Publication Number Publication Date
ES2129392T3 true ES2129392T3 (es) 1999-06-16

Family

ID=11265471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90402141T Expired - Lifetime ES2129392T3 (es) 1989-07-27 1990-07-25 Derivados de di-lisogangliosidos.

Country Status (16)

Country Link
US (1) US5523294A (es)
EP (1) EP0410883B1 (es)
JP (1) JPH03218391A (es)
KR (1) KR910002886A (es)
AT (1) ATE178334T1 (es)
AU (1) AU641173B2 (es)
CA (1) CA2022139A1 (es)
DE (1) DE69033027T2 (es)
ES (1) ES2129392T3 (es)
FI (1) FI903754A7 (es)
HU (1) HU208834B (es)
IL (1) IL95170A0 (es)
IT (1) IT1232176B (es)
NO (1) NO903334L (es)
NZ (1) NZ234650A (es)
PL (1) PL165347B1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi
GB2349822A (en) * 1999-03-25 2000-11-15 Benjamin Chang Splinting device
AU2002326805B2 (en) 2001-08-29 2009-01-22 Seneb Biosciences, Inc. Novel synthetic ganglioside derivatives and compositions thereof
WO2004080960A2 (en) 2003-03-06 2004-09-23 Neose Technologies Inc. Methods and compositions for the enzymatic synthesis of gangliosides
WO2010111530A1 (en) 2009-03-25 2010-09-30 Seneb Biosciences, Inc. Glycolipids as treatment for disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1046051B (it) 1975-08-13 1980-06-30 Fidia Spa Nuova applicazione terapeutica dei gangliosidi e procedimento per la loro estrazione
US4716223A (en) 1981-08-04 1987-12-29 Fidia, S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
US4593091A (en) 1981-08-04 1986-06-03 Fidia, S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
US4476119A (en) 1981-08-04 1984-10-09 Fidia S.P.A. Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
IT1199116B (it) 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
IT1212041B (it) * 1987-11-02 1989-11-08 Fidia Farmaceutici Gangliosidi esteri interni come agenti terapeutici capaci di eliminare il dolore nelle neuropatie periferiche
IT1235011B (it) * 1988-07-26 1992-06-16 Fidia Farmaceutici Sintesi di derivati di glicosfingolipidi ed in particolare di gangliosidi utilizzabili per la preparazione di immunoadsorbenti ed adsorbenti per affinita' impiegabili per la purificazione di anticorpi e di tossine specifiche, e per uso diagnostico
IT1235161B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisogangliosidi
IT1232175B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Analoghi semisintetici di gangliosidi
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.

Also Published As

Publication number Publication date
NZ234650A (en) 1992-01-29
IL95170A0 (en) 1991-06-10
AU641173B2 (en) 1993-09-16
KR910002886A (ko) 1991-02-26
HUT56576A (en) 1991-09-30
FI903754A7 (fi) 1991-01-28
EP0410883A3 (en) 1993-01-20
HU208834B (en) 1994-01-28
JPH03218391A (ja) 1991-09-25
IT8948247A0 (it) 1989-07-27
PL165347B1 (pl) 1994-12-30
AU5982790A (en) 1991-01-31
EP0410883B1 (en) 1999-03-31
DE69033027D1 (de) 1999-05-06
HU904641D0 (en) 1991-01-28
DE69033027T2 (de) 1999-11-25
NO903334L (no) 1991-01-28
US5523294A (en) 1996-06-04
NO903334D0 (no) 1990-07-26
PL286248A1 (en) 1991-08-26
FI903754A0 (fi) 1990-07-27
IT1232176B (it) 1992-01-25
ATE178334T1 (de) 1999-04-15
CA2022139A1 (en) 1991-01-28
EP0410883A2 (en) 1991-01-30

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