ES2129430T3 - Analogos superactivos del factor liberador de la hormona del crecimiento. - Google Patents

Analogos superactivos del factor liberador de la hormona del crecimiento.

Info

Publication number
ES2129430T3
ES2129430T3 ES92303717T ES92303717T ES2129430T3 ES 2129430 T3 ES2129430 T3 ES 2129430T3 ES 92303717 T ES92303717 T ES 92303717T ES 92303717 T ES92303717 T ES 92303717T ES 2129430 T3 ES2129430 T3 ES 2129430T3
Authority
ES
Spain
Prior art keywords
grf
provides
growth hormone
analogs
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92303717T
Other languages
English (en)
Inventor
Richard Dennis Dimarchi
Mark Louis Heiman
James Edwin Shields
David Lee Smiley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2129430T3 publication Critical patent/ES2129430T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
  • Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Farming Of Fish And Shellfish (AREA)

Abstract

LA INVENCION SUMINISTRA UNA HORMONA DEL CRECIMIENTO MODIFICADA EN EL AMINO TERMINAL QUE LIBERA ANALOGOS (GRF) DE UNA POTENCIA Y ACTIVIDAD SUPERIORES CUANDO SE COMPARA CON EL GRF NATIVO O LOS ANALOGOS DEL GRF PREVIAMENTE DESCRITOS. LA INVENCION TAMBIEN SUMINISTRA ANALOGOS DEL GRF MODIFICADOS EN EL AMINO TERMINAL QUE COMPRENDE PEPTIDOS DEL GRF QUE INCORPORAN MODIFICACIONES DEL ACIDO AMINO SELECCIONADOS A PARTIR DE LAS FORMAS QUE SE PRODUCEN DE MODO NATURAL DE LOS PEPTIDOS DEL GRF. SE DESCRIBEN ANALOGOS SUPERIORES DE LAS ESPECIES BOBINA, PORCINA, HUMANA Y OTRAS ESPECIES. LA INVENCION TAMBIEN SUMINISTRA UN METODO PARA PROMOVER LA LIBERACION DE LA HORMONA DEL CRECIMIENTO USANDO LA HORMONA DE LA INVENCION. TAMBIEN SE SUMINISTRAN FORMULAS FARMACEUTICAS DE LOS COMPUESTOS DE LA INVENCION. LA INVENCION TAMBIEN SUMINISTRA METODOS DE TRATAMIENTOS PARA VARIAS ENFERMEDADES QUE RESULTAN DE NIVELES INSUFICIENTES DE LA HORMONA DEL CRECIMIENTO USANDO ESTOS COMPUESTOS. LA INVENCION TAMBIEN SUMINISTRA UN METODO PARA AUMENTAR LA MASA MUSCULAR EN MAMIFEROS MEDIANTE LA ADMINISTRACION DE ESTOS COMPUESTOS.
ES92303717T 1991-04-26 1992-04-24 Analogos superactivos del factor liberador de la hormona del crecimiento. Expired - Lifetime ES2129430T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69209091A 1991-04-26 1991-04-26

Publications (1)

Publication Number Publication Date
ES2129430T3 true ES2129430T3 (es) 1999-06-16

Family

ID=24779221

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92303717T Expired - Lifetime ES2129430T3 (es) 1991-04-26 1992-04-24 Analogos superactivos del factor liberador de la hormona del crecimiento.

Country Status (24)

Country Link
EP (1) EP0511003B1 (es)
JP (1) JPH05279388A (es)
KR (1) KR100233804B1 (es)
CN (1) CN1068123A (es)
AT (1) ATE178073T1 (es)
AU (1) AU1513292A (es)
BR (1) BR9201512A (es)
CA (1) CA2067304A1 (es)
CZ (1) CZ285567B6 (es)
DE (1) DE69228717T2 (es)
DK (1) DK0511003T3 (es)
ES (1) ES2129430T3 (es)
FI (1) FI921855L (es)
GR (1) GR3030459T3 (es)
HU (1) HUT64589A (es)
IE (1) IE921338A1 (es)
IL (1) IL101620A (es)
MX (1) MX9201878A (es)
NO (1) NO921595L (es)
NZ (1) NZ242459A (es)
SG (1) SG46364A1 (es)
TW (1) TW360661B (es)
YU (1) YU44292A (es)
ZA (1) ZA922746B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453418A (en) * 1988-03-07 1995-09-26 Eli Lilly And Company Ractopamine and growth hormone combinations
AU673190B2 (en) * 1992-07-13 1996-10-31 Bionebraska, Inc. Method for modification of recombinant polypeptides
JP3576170B2 (ja) * 1995-05-26 2004-10-13 セラテクノロジーズ・インコーポレーテッド 生物学的活性が増加したキメラ脂肪体プロgrf類似体
EP0766966A3 (en) * 1995-09-08 2001-02-28 Eli Lilly And Company Method of treating insulin resistance

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4628043A (en) * 1983-04-26 1986-12-09 The Salk Institute For Biological Studies Hypothalamic GRF agonists
US4626523A (en) * 1983-09-13 1986-12-02 The Salk Institute For Biological Studies GRF analogs II
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
CA1271600A (en) * 1985-01-07 1990-07-10 David Howard Coy Growth hormone-releasing peptides and method of treating mammals therewith

Also Published As

Publication number Publication date
TW360661B (en) 1999-06-11
FI921855A7 (fi) 1992-10-27
CN1068123A (zh) 1993-01-20
IL101620A (en) 1996-08-04
CA2067304A1 (en) 1992-10-27
DE69228717D1 (de) 1999-04-29
NZ242459A (en) 1993-12-23
ZA922746B (en) 1992-12-30
FI921855A0 (fi) 1992-04-24
AU690264B2 (en) 1998-04-23
HUT64589A (en) 1994-01-28
HU9201399D0 (en) 1992-08-28
EP0511003B1 (en) 1999-03-24
MX9201878A (es) 1992-10-01
AU1513292A (en) 1992-10-29
FI921855L (fi) 1992-10-27
EP0511003A1 (en) 1992-10-28
SG46364A1 (en) 1998-02-20
DK0511003T3 (da) 1999-05-25
KR100233804B1 (ko) 1999-12-01
IE921338A1 (en) 1992-11-04
CS121192A3 (en) 1992-11-18
IL101620A0 (en) 1992-12-30
JPH05279388A (ja) 1993-10-26
BR9201512A (pt) 1992-12-01
ATE178073T1 (de) 1999-04-15
YU44292A (sh) 1994-06-24
KR920019817A (ko) 1992-11-20
CZ285567B6 (cs) 1999-09-15
NO921595D0 (no) 1992-04-24
GR3030459T3 (en) 1999-10-29
NO921595L (no) 1992-10-27
AU2333495A (en) 1995-09-14
DE69228717T2 (de) 1999-08-19

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