ES2129668T3 - Suministro iontoforetico de un farmaco antimigraña. - Google Patents
Suministro iontoforetico de un farmaco antimigraña.Info
- Publication number
- ES2129668T3 ES2129668T3 ES94926855T ES94926855T ES2129668T3 ES 2129668 T3 ES2129668 T3 ES 2129668T3 ES 94926855 T ES94926855 T ES 94926855T ES 94926855 T ES94926855 T ES 94926855T ES 2129668 T3 ES2129668 T3 ES 2129668T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- formula
- alkyl
- supply
- bivalent radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Electrotherapy Devices (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
LA INVENCION SE REFIERE AL SUMINISTRO IONTOFORETICO A UN PACIENTE, MAS PARTICULAR A UN PACIENTE DE MIGRAÑA, DE UN COMPUESTO DE LA FORMULA (I) SEGUN SE MUESTRA. LA INVENCION TAMBIEN SE REFIERE A UN DISPOSITIVO PARA EL SUMINISTRO IONTOFORETICO DE UN COMPUESTO DE LA FORMULA (I) ASI COMO A UNA COMPOSICION QUE CONTIENE UN COMPUESTO DE LA FORMULA (I), QUE PUEDE APLICARSE EN UN DISPOSITIVO PARA EL SUMINISTRO IONTOFORETICO. LOS COMPUESTOS SON GUANIDINAS SUSTITUIDAS CON BENZOPIRANALQUILAMINOALQUILO QUE TIENEN LA FORMULA (I), LAS SALES DE ADICION ACIDA FARMACOLOGICAMENTE ACEPTABLE DE LOS MISMOS, Y LAS FORMAS ESTEREOQUIMICAMENTE ISOMERICAS DE LOS MISMOS, EN DONDE R1 ES HIDROGENO O ALQUILO C{SUB,1-6}, R2 ES HIDROGENO, ALQUILO C{SUB,1-6}, ALQUENILO C{SUB,3-6} O ALQUINILO C{SUB,3-6}, R3 ES HIDROGENO O ALQUILO C{SUB,1-6}; O R2 Y R3 TOMADAS JUNTAS FORMAN UN RADICAL BIVALENTE DE LA FORMULA -(CH{SUB,2}){SUB,M}- EN DONDE M ES 4 O 5; O R1 Y R2 TOMADAS JUNTAS FORMAN UN RADICAL BIVALENTE DE LA FORMULA -CH=CH- ODE LA FORMULA -(CH{SUB,2}){SUB,N}-, EN DONDE N ES 2, 3 O 4; O R3 PUEDE REPRESENTAR UN ENLACE CUANDO R1 Y R2 TOMDAS JUNTAS FORMAN UN RADICAL BIVALENTE DE LA FORMULA CH=CH-CH=; R4 Y R5 SON CADA UNA INDEPENDIENTEMENTE HIDROGENO O ALQUIL C{SUB,1-6}; ALQUIL1 ES UN RADICAL BIVALENTE DE ALCANEDIILO C{SUB,1-3}; ALQUIL2 ES UN RADICAL BIVALENTE DE ALCANEDIILO C{SUB,2-15}; Y R6 Y R7 ES CADA UNA INDEPENDIENTEMENTE HIDROGENO, HALO, ALQUILO C{SUB,1-6}, ALQUENILO C{3-6}, ALQUINILO C{SUB,3-6}, HIDROXIDO, ALQUILOXIDO C{SUB,1-6} O CIANO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93202523 | 1993-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2129668T3 true ES2129668T3 (es) | 1999-06-16 |
Family
ID=8214068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94926855T Expired - Lifetime ES2129668T3 (es) | 1993-08-27 | 1994-08-19 | Suministro iontoforetico de un farmaco antimigraña. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5674871A (es) |
| EP (1) | EP0719138B1 (es) |
| JP (1) | JP2921987B2 (es) |
| KR (1) | KR100187632B1 (es) |
| CN (1) | CN1096857C (es) |
| AT (1) | ATE176591T1 (es) |
| AU (1) | AU687876B2 (es) |
| BR (1) | BR9407522A (es) |
| CA (1) | CA2168449A1 (es) |
| CZ (1) | CZ290473B6 (es) |
| DE (1) | DE69416522T2 (es) |
| DK (1) | DK0719138T3 (es) |
| ES (1) | ES2129668T3 (es) |
| FI (1) | FI960887A0 (es) |
| GR (1) | GR3029920T3 (es) |
| HR (1) | HRP940481A2 (es) |
| HU (1) | HUT75062A (es) |
| IL (1) | IL110784A (es) |
| MY (1) | MY111022A (es) |
| NO (1) | NO317628B1 (es) |
| NZ (1) | NZ273304A (es) |
| PH (1) | PH31437A (es) |
| PL (1) | PL176290B1 (es) |
| RU (1) | RU2166315C2 (es) |
| SG (1) | SG50469A1 (es) |
| SI (1) | SI9400333B (es) |
| WO (1) | WO1995005815A1 (es) |
| ZA (1) | ZA946533B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5853383A (en) * | 1995-05-03 | 1998-12-29 | Alza Corporation | Preparation for formulations for electrotransport drug delivery |
| US7137975B2 (en) * | 2001-02-13 | 2006-11-21 | Aciont, Inc. | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent |
| CA2443326A1 (en) * | 2001-04-04 | 2002-10-17 | Alza Corporation | Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition |
| WO2002089803A1 (fr) * | 2001-05-07 | 2002-11-14 | Sankyo Company, Limited | Composition d'ionophorese |
| JP4394444B2 (ja) * | 2001-10-24 | 2010-01-06 | パワー ペーパー リミティド | 活性物質の制御された皮膚内デリバリーのためのデバイス及び方法 |
| ITMI20021200A1 (it) * | 2002-06-03 | 2003-12-03 | Gafitex S R L | Tessuto atto ad esplicare un effetto barriera contro campi magnetici ed elettromagnetici e/o effetti di metalloterapia |
| US8016811B2 (en) * | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
| US20050220439A1 (en) * | 2004-03-19 | 2005-10-06 | Carton Owen A | Interactive multimedia system and method |
| WO2007009462A2 (en) * | 2005-07-15 | 2007-01-25 | Region Hovedstaden V/Glostrup Hospital | Treatment of migraine and headaches |
| GB2430364A (en) * | 2005-09-22 | 2007-03-28 | Carl Ernest Alexander | Soft agar bolus for oral drug delivery |
| WO2007120747A2 (en) * | 2006-04-13 | 2007-10-25 | Nupathe Inc. | Transdermal methods and systems for the delivery of anti-migraine compounds |
| RU2352359C1 (ru) * | 2007-10-24 | 2009-04-20 | Общество с ограниченнной ответственностью "НПО Текстильпрогресс Инженерной Академии " (ООО "НПО Текстильпрогресс ИА") | Способ создания композиции для доставки лекарственного препарата в полости организма при заболеваниях |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4028125A1 (de) * | 1990-01-17 | 1991-07-18 | Klimke Markus | Applikationsvorrichtung fuer die geregelte dosierung verschiedener pharmakons mittels elektrischem strom zum perkutanen transport zur lokalen und systemischen therapie |
| JP3740549B2 (ja) * | 1990-03-30 | 2006-02-01 | アルザ・コーポレーション | イオン侵透療法による薬剤投与の装置と方法 |
| SI9300097B (en) * | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
-
1994
- 1994-07-15 PH PH48643A patent/PH31437A/en unknown
- 1994-08-19 NZ NZ273304A patent/NZ273304A/en unknown
- 1994-08-19 EP EP94926855A patent/EP0719138B1/en not_active Expired - Lifetime
- 1994-08-19 DE DE69416522T patent/DE69416522T2/de not_active Expired - Fee Related
- 1994-08-19 WO PCT/EP1994/002764 patent/WO1995005815A1/en not_active Ceased
- 1994-08-19 DK DK94926855T patent/DK0719138T3/da active
- 1994-08-19 CA CA002168449A patent/CA2168449A1/en not_active Abandoned
- 1994-08-19 KR KR1019960700410A patent/KR100187632B1/ko not_active Expired - Fee Related
- 1994-08-19 PL PL94313255A patent/PL176290B1/pl not_active IP Right Cessation
- 1994-08-19 ES ES94926855T patent/ES2129668T3/es not_active Expired - Lifetime
- 1994-08-19 BR BR9407522A patent/BR9407522A/pt not_active Application Discontinuation
- 1994-08-19 US US08/586,700 patent/US5674871A/en not_active Expired - Fee Related
- 1994-08-19 RU RU96105930/14A patent/RU2166315C2/ru not_active IP Right Cessation
- 1994-08-19 CN CN94193196A patent/CN1096857C/zh not_active Expired - Fee Related
- 1994-08-19 AT AT94926855T patent/ATE176591T1/de not_active IP Right Cessation
- 1994-08-19 CZ CZ1996570A patent/CZ290473B6/cs not_active IP Right Cessation
- 1994-08-19 AU AU76542/94A patent/AU687876B2/en not_active Ceased
- 1994-08-19 HU HU9600471A patent/HUT75062A/hu unknown
- 1994-08-19 JP JP7507338A patent/JP2921987B2/ja not_active Expired - Fee Related
- 1994-08-19 SG SG1996002184A patent/SG50469A1/en unknown
- 1994-08-25 MY MYPI94002234A patent/MY111022A/en unknown
- 1994-08-25 IL IL11078494A patent/IL110784A/xx not_active IP Right Cessation
- 1994-08-26 SI SI9400333A patent/SI9400333B/sl not_active IP Right Cessation
- 1994-08-26 HR HR93.202.523.2A patent/HRP940481A2/hr not_active Application Discontinuation
- 1994-08-26 ZA ZA946533A patent/ZA946533B/xx unknown
-
1996
- 1996-02-26 FI FI960887A patent/FI960887A0/fi not_active Application Discontinuation
- 1996-02-26 NO NO19960769A patent/NO317628B1/no unknown
-
1999
- 1999-04-07 GR GR990401012T patent/GR3029920T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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