ES2130274T3 - Nuevos derivados lipidicos ciclicos como potentes antagonistas del factor activador de las plaquetas (paf). - Google Patents

Nuevos derivados lipidicos ciclicos como potentes antagonistas del factor activador de las plaquetas (paf).

Info

Publication number
ES2130274T3
ES2130274T3 ES93913613T ES93913613T ES2130274T3 ES 2130274 T3 ES2130274 T3 ES 2130274T3 ES 93913613 T ES93913613 T ES 93913613T ES 93913613 T ES93913613 T ES 93913613T ES 2130274 T3 ES2130274 T3 ES 2130274T3
Authority
ES
Spain
Prior art keywords
group
paf
formula
lipid derivatives
powerful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93913613T
Other languages
English (en)
Inventor
Soon Hyung Woo
Sung Kee Chung
Soo Ho Ban
Byoung Eog Kim
Si Hwan Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute of Industrial Science and Technology
Posco Holdings Inc
Original Assignee
Research Institute of Industrial Science and Technology
Pohang Iron and Steel Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019920011554A external-priority patent/KR950013770B1/ko
Priority claimed from KR1019930005778A external-priority patent/KR960015088B1/ko
Application filed by Research Institute of Industrial Science and Technology, Pohang Iron and Steel Co Ltd filed Critical Research Institute of Industrial Science and Technology
Application granted granted Critical
Publication of ES2130274T3 publication Critical patent/ES2130274T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN UNOS NUEVOS DERIVADOS DIOL CICLICOS REPRESENTADOS POR LAS FORMULAS (I) Y (II), DONDE Y ES O, S, SO, SO2, (CH2)M DONDE M ES 0 O UN ENTERO DE 1 A 5, O UN GRUPO NRA DONDE RA ES H, ALQUILO INFERIOR, ALCOXICARBONILO INFERIOR, CARBONILO, ARILO, ARILALQUILO O ACILO; R1 ES GRUPO ALQUILCARBAMOILO O ALQUILO; R2 ES UN GRUPO DE FORMULA (III), DONDE T SE REFIERE A UN ENLACE COVALENTE SENCILLO, UN GRUPO CO, PO3-, C(O)O, O CONRB, DONDE RB ES H, ALQUILO INFERIOR O ACILO; N ES UN ENTERO DE 1 A 10; V ES BIEN (I) EL GRUPO INDICADO POR LA FORMULA (IV) DONDE R5, R6 Y R7 SON GRUPOS ALQUILOS INFERIOR IGUALES O DIFERENTES, O DOS O TRES DE R5, R6 Y R7 JUNTO CON EL HIDROGENO ADYACENTE DEL GRUPO FORMAN UN GRUPO AMONIO HETEROCICLICO, O (II) EL GRUPO INDICADO DE FORMULA (A) DONDE R8 ES UN GRUPO ALQUILO INFERIOR; Q ES 1 O 0; X ES UN ANION FARMACEUTICAMENTE ACEPTABLE. LOS COMPUESTOS SON POTENTES ANTAGONISTAS DE PAF Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES QUE COMPRENDEN EL PAF
ES93913613T 1992-06-30 1993-06-30 Nuevos derivados lipidicos ciclicos como potentes antagonistas del factor activador de las plaquetas (paf). Expired - Lifetime ES2130274T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1019920011554A KR950013770B1 (ko) 1992-06-30 1992-06-30 혈소판활성인자(paf)에 길항작용을 하는 4각고리 화합물 및 그 제조방법
KR1019930005778A KR960015088B1 (ko) 1993-04-07 1993-04-07 혈소판 활성인자에 길항작용을 하는 1,1-비스(히드록시메틸) 시클로알칸 화합물
US08/476,642 US5610310A (en) 1992-06-30 1995-06-07 Cyclic lipid derivatives as potent PAF antagonists

Publications (1)

Publication Number Publication Date
ES2130274T3 true ES2130274T3 (es) 1999-07-01

Family

ID=27348840

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93913613T Expired - Lifetime ES2130274T3 (es) 1992-06-30 1993-06-30 Nuevos derivados lipidicos ciclicos como potentes antagonistas del factor activador de las plaquetas (paf).

Country Status (6)

Country Link
US (1) US5610310A (es)
EP (1) EP0607374B1 (es)
JP (1) JP3298883B2 (es)
DE (1) DE69324342T2 (es)
ES (1) ES2130274T3 (es)
WO (1) WO1994000447A1 (es)

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5767589A (en) * 1980-10-14 1982-04-24 Takeda Chem Ind Ltd Carbamic acid esters
US4429162A (en) * 1982-02-01 1984-01-31 Ciba-Geigy Corporation Perfluoroalkyl phenols and naphthols
JPS60104066A (ja) * 1983-11-10 1985-06-08 Ono Pharmaceut Co Ltd グリセリン誘導体
CA1235130A (en) * 1984-06-19 1988-04-12 Ronald F. Mason Azetidine derivatives and their preparation
GB8415615D0 (en) * 1984-06-19 1984-07-25 Shell Int Research Preparing azetidine derivatives
US4891363A (en) * 1985-07-26 1990-01-02 Sankyo Company Limited Cyclic ether derivatives and their use
DE3532478A1 (de) * 1985-09-09 1987-03-19 Schering Ag Oxetan- und thietanderivate, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
GB8528959D0 (en) * 1985-11-25 1986-01-02 Leo Pharm Prod Ltd Chemical compounds
DE3616137A1 (de) * 1986-05-14 1987-11-19 Bayer Ag Verfahren zur herstellung von carbonsaeureestern
IL83163A (en) * 1986-07-18 1991-06-10 Erba Carlo Spa Cycloalkyl-substituted 4-pyridyl derivatives,their preparation and pharmaceutical compositions containing them
DE3778248D1 (de) * 1986-08-21 1992-05-21 Merck & Co Inc 1,3-diarylcyclopentane und deren abkoemmlinge als paf-antagonisten.
CN1030415A (zh) * 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
GB2209031A (en) * 1987-08-24 1989-04-26 Merck & Co Inc Processes for preparing 1,3-diaryl cyclopentanes and derivatives thereof as PAF antagonists
DE3871705T2 (de) * 1987-10-13 1992-12-17 Uriach & Cia Sa J 2,4-disubstituierte tetrahydrofuranderivate.
ES2005031A6 (es) * 1987-10-13 1989-02-16 Uriach & Cia Sa J Procedimiento para la obtencion de 1,3-dioxolanos 2,4-disustituidos.
US4851450A (en) * 1987-10-26 1989-07-25 Demopoulos Constantine A Compounds for inhibition of platelet activating factor activity
WO1989007099A1 (en) * 1988-02-05 1989-08-10 Schering Corporation 2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use
FI97883C (fi) * 1988-07-04 1997-03-10 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen glyserolijohdannaisen valmistamiseksi
JP2824536B2 (ja) * 1989-01-30 1998-11-11 武田薬品工業株式会社 ピリジニウム誘導体
JP2857191B2 (ja) * 1989-12-27 1999-02-10 エーザイ株式会社 シクロヘキサンジオール系化合物

Also Published As

Publication number Publication date
WO1994000447A1 (en) 1994-01-06
US5610310A (en) 1997-03-11
EP0607374A1 (en) 1994-07-27
JP3298883B2 (ja) 2002-07-08
EP0607374B1 (en) 1999-04-07
DE69324342D1 (de) 1999-05-12
DE69324342T2 (de) 1999-11-04
JPH06510306A (ja) 1994-11-17

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