ES2130406T3 - Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico. - Google Patents

Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.

Info

Publication number
ES2130406T3
ES2130406T3 ES94906771T ES94906771T ES2130406T3 ES 2130406 T3 ES2130406 T3 ES 2130406T3 ES 94906771 T ES94906771 T ES 94906771T ES 94906771 T ES94906771 T ES 94906771T ES 2130406 T3 ES2130406 T3 ES 2130406T3
Authority
ES
Spain
Prior art keywords
soluble
iron oxide
magnetic iron
carboxipolisacarido
approximately
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94906771T
Other languages
English (en)
Other versions
ES2130406T5 (es
Inventor
Masakatsu Hasegawa
Yoshio Ito
Hisato Yamada
Hideo Nagae
Nahoko Tozawa
Yukari Taishi Hino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meito Sangyo KK
Original Assignee
Meito Sangyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16866463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2130406(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Meito Sangyo KK filed Critical Meito Sangyo KK
Publication of ES2130406T3 publication Critical patent/ES2130406T3/es
Application granted granted Critical
Publication of ES2130406T5 publication Critical patent/ES2130406T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Hard Magnetic Materials (AREA)
  • Soft Magnetic Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Iron (AREA)

Abstract

UN COMPUESTO QUE TIENE UN DIAMETRO PEQUEÑO DE PARTICULA Y COMPUESTO DE UN CARBOXIPOLISACARIDO HIDROSOLUBLE Y UN OXIDO DE HIERRO MAGNETICO QUE TIENE UN DIAMETRO DE NUCLEO DE APROXIMADAMENTE 2 A 7 NM, DONDE EL DIAMETRO TOTAL DE APROXIMADAMENTE 10 A 50NM, LA RELACION DEL DIAMETRO TOTAL RESPECTO DEL DIAMETRO DE NUCLEO ES APROXIMADAMENTE 55 O MENOS Y LA CAPACIDAD DE RELAJACION T2 DE APROXIMADAMENTE 10 A 150 (MM.SEG.)-1. EL COMPUESTO SE REDUCE EN EFECTOS SECUNDARIOS Y TOXICIDAD Y ES UTIL COMO PREPARACION DE HIERRO. MEDIO DE CONTRATE EN RAYOS X, MEDIO DE CONTRASTE EN MRI, REACTIVO PARA MEDICION DEL TORRENTE SANGUINEO, VEHICULO DE DROGA, ETC EN LOS CAMPOS DE LA MEDICINA BIOLOGICA E INGENIERIA.
ES94906771T 1992-08-05 1993-08-04 Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico. Expired - Lifetime ES2130406T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22779292 1992-08-05

Publications (2)

Publication Number Publication Date
ES2130406T3 true ES2130406T3 (es) 1999-07-01
ES2130406T5 ES2130406T5 (es) 2003-12-16

Family

ID=16866463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94906771T Expired - Lifetime ES2130406T5 (es) 1992-08-05 1993-08-04 Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.

Country Status (9)

Country Link
US (1) US5766572A (es)
EP (1) EP0656368B2 (es)
JP (1) JP3337075B2 (es)
AT (1) ATE179185T1 (es)
DE (1) DE69324591T3 (es)
DK (1) DK0656368T4 (es)
ES (1) ES2130406T5 (es)
GR (1) GR3030030T3 (es)
WO (1) WO1994003501A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130406T5 (es) † 1992-08-05 2003-12-16 Meito Sangyo Kk Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.
DE69332120T2 (de) * 1993-08-12 2003-02-27 Advanced Magnetics, Inc. Verwendung von mit polysacchariden überzogenen superparamagnetischen oxid-kolloiden
DE4428851C2 (de) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
RU2147243C1 (ru) 1994-09-27 2000-04-10 Нюкомед Имагинг А/С Контрастное средство
GB9600427D0 (en) * 1996-01-10 1996-03-13 Nycomed Imaging As Contrast media
CA2242647A1 (en) 1996-01-10 1997-07-17 Amersham Health As Contrast media
CN1151846C (zh) 1996-08-05 2004-06-02 舍林公开股份有限公司 核磁共振断层扫描成像用造影剂的制备方法
WO1998008899A1 (en) * 1996-08-30 1998-03-05 Meito Sangyo Kabushiki Kaisha Polysaccharide derivative/magnetic metal oxide composite
EP0967227A1 (en) * 1998-06-04 1999-12-29 Mitsubishi Gas Chemical Company, Inc. Process for producing carboxypolysaccharide
US6203778B1 (en) 1998-12-08 2001-03-20 The Regents Of The University Of California Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization
US7179660B1 (en) * 2000-03-06 2007-02-20 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
US7169618B2 (en) * 2000-06-28 2007-01-30 Skold Technology Magnetic particles and methods of producing coated magnetic particles
KR20020018260A (ko) * 2000-09-01 2002-03-08 조옥순 자동차 제동장치용 로터의 재질개선 방법
DE10046514A1 (de) * 2000-09-15 2002-04-25 Diagnostikforschung Inst Verfahren zur bildlichen Darstellung und Diagnose von Thromben mittels Kernspintomographie unter Verwendung partikulärer Kontrastmittel
GB0025414D0 (en) * 2000-10-16 2000-11-29 Consejo Superior Investigacion Nanoparticles
EP1335003A3 (en) * 2002-02-06 2004-04-07 Toyo Boseki Kabushiki Kaisha Magnetic carrier capable of binding with protein and purification method of protein utilizing the magnetic carrier
US20030185757A1 (en) * 2002-03-27 2003-10-02 Mayk Kresse Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
ES2475207T3 (es) 2004-07-15 2014-07-10 Tetralogic Pharmaceuticals Corporation Compuestos de unión a IAP
WO2006051732A1 (ja) * 2004-11-10 2006-05-18 Konica Minolta Medical & Graphic, Inc. 被覆磁性粒子含有製剤およびその製造方法、並びに診断治療システム
MX2007010371A (es) * 2005-02-25 2008-01-11 Tetralogic Pharmaceuticals Inhibidores dimericos iap.
JP5321772B2 (ja) * 2005-06-15 2013-10-23 戸田工業株式会社 磁性粒子含有医薬用原薬
EP1738773A1 (de) * 2005-06-29 2007-01-03 Schering AG Magnetische Eisenoxidpartikel enthaltende Zusammensetzung und deren Vervendung in bildgebenden Verfahren
CA2617642A1 (en) * 2005-08-09 2007-02-22 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
US20100256046A1 (en) * 2009-04-03 2010-10-07 Tetralogic Pharmaceuticals Corporation Treatment of proliferative disorders
US20070258907A1 (en) * 2006-04-24 2007-11-08 Davis Mark E Polymer-coated paramagnetic particles
FR2918868A1 (fr) 2006-06-06 2009-01-23 Guerbet Sa Methode d'imagerie de diagnostic utilisant en combinaison avec l'imagerie de diffusion de l'eau, des agents de contraste
US20100056495A1 (en) * 2006-07-24 2010-03-04 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
WO2008014240A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
JP5452223B2 (ja) * 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ阻害剤
MX2009000824A (es) * 2006-07-24 2009-02-04 Tetralogic Pharmaceuticals Cor Antagonistas dimericos de las proteinas inhibidoras de la apoptosis.
US20100143499A1 (en) * 2006-07-24 2010-06-10 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
DE102007004424A1 (de) 2007-01-23 2008-07-24 Bayer Schering Pharma Aktiengesellschaft Eisenoxid-bindende Peptide
CN101547706B (zh) 2007-04-12 2013-07-10 延世大学校产学协力团 包含含锌磁性金属氧化物纳米颗粒的磁共振成像造影剂
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
JP2013526616A (ja) 2010-05-26 2013-06-24 ザ ジェネラル ホスピタル コーポレイション 磁性ナノ粒子
JPWO2012026194A1 (ja) * 2010-08-25 2013-10-28 国立大学法人徳島大学 金属酸化物ナノ粒子構造体およびその製造方法
KR101303567B1 (ko) * 2011-03-08 2013-09-23 주식회사 인트론바이오테크놀로지 카르복실기가 도입된 만난으로 코팅된 자기공명영상 조영제 및 그것의 제조 방법
EP2679247B1 (en) * 2011-03-08 2018-09-19 Intron Biotechnology, Inc. Carboxylic mannan-coated contrast agent for magnetic resonance imaging
MX390935B (es) 2015-06-04 2025-03-21 Endomagnetics Ltd Materiales marcadores y formas para la localización de marcadores magnéticos (mml).

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5913521B2 (ja) * 1975-06-19 1984-03-30 メイトウサンギヨウ カブシキガイシヤ 磁性酸化鉄・デキストラン複合体の製造法
US4335094A (en) * 1979-01-26 1982-06-15 Mosbach Klaus H Magnetic polymer particles
US4370476A (en) † 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
SE463651B (sv) * 1983-12-21 1991-01-07 Nycomed As Diagnostikum och kontrastmedel
US4788281A (en) † 1984-01-04 1988-11-29 Tosoni Anthony L Dextran hexonic acid derivative, ferric hydroxide complex and method manufacture thereof
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
US4675173A (en) * 1985-05-08 1987-06-23 Molecular Biosystems, Inc. Method of magnetic resonance imaging of the liver and spleen
US4849210A (en) * 1985-05-08 1989-07-18 Molecular Biosystems, Inc. Magnetic resonance imaging of liver and spleen with superparamagnetic contrast agents
AU6621586A (en) * 1985-11-18 1987-06-02 University Of Texas System, The Polychelating agents for image and spectral enhancement (and spectral shift)
US4770183A (en) † 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
US4951675A (en) † 1986-07-03 1990-08-28 Advanced Magnetics, Incorporated Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
US4827945A (en) * 1986-07-03 1989-05-09 Advanced Magnetics, Incorporated Biologically degradable superparamagnetic materials for use in clinical applications
US4925678A (en) * 1987-04-01 1990-05-15 Ranney David F Endothelial envelopment drug carriers
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JP2726520B2 (ja) † 1989-10-20 1998-03-11 名糖産業株式会社 有機磁性複合体
JPH03141119A (ja) * 1989-10-25 1991-06-17 Nippon Telegr & Teleph Corp <Ntt> 磁性微粒子の製造方法
JP2558908B2 (ja) * 1990-02-16 1996-11-27 日本電信電話株式会社 磁性微粒子の製造方法
ES2110500T3 (es) 1991-06-11 1998-02-16 Meito Sangyo Kk Material compuesto oxidado que comprende carboxipolisacarido soluble en agua y oxido de hierro magnetico.
ES2130406T5 (es) † 1992-08-05 2003-12-16 Meito Sangyo Kk Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.

Also Published As

Publication number Publication date
EP0656368A1 (en) 1995-06-07
EP0656368A4 (en) 1996-05-08
ATE179185T1 (de) 1999-05-15
EP0656368B1 (en) 1999-04-21
GR3030030T3 (en) 1999-07-30
DE69324591D1 (de) 1999-05-27
DK0656368T3 (da) 1999-10-25
ES2130406T5 (es) 2003-12-16
EP0656368B2 (en) 2003-06-04
JP3337075B2 (ja) 2002-10-21
DK0656368T4 (da) 2003-09-29
DE69324591T2 (de) 1999-08-19
WO1994003501A1 (fr) 1994-02-17
DE69324591T3 (de) 2004-02-12
US5766572A (en) 1998-06-16

Similar Documents

Publication Publication Date Title
ES2130406T3 (es) Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.
Brasseur et al. Actinomycin D adsorbed on polymethylcyanoacrylate nanoparticles: increased efficiency against an experimental tumor
Gu et al. Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads
Bentivoglio et al. Two new fluorescent retrograde neuronal tracers which are transported over long distances
Cai et al. Organic nanoparticles with aggregation‐induced emission for bone marrow stromal cell tracking in a rat PTI model
Zimmermann et al. The effect of encapsulation in red blood cells on the distribution of methotrexate in mice
Camougis et al. Potency difference between the zwitterion form and the cation forms of tetrodotoxin
Sloboda et al. Griseofulvin: association with tubulin and inhibition of in vitro microtubule assembly
Aviram et al. Plasma lipoproteins affect platelet malondialdehyde and thromboxane B2 production
Midgley et al. Nature of colchicine resistance in golden hamster
Farshori et al. Effects of the microtubule depolymerizing and stabilizing agents Nocodazole and taxol on glucose-induced insulin secretion from hamster islet tumor (HIT) cells
West et al. Mechanisms behind the resistance of spheroids to photodynamic treatment: a flow cytometry study
Gout et al. Vinblastine and vincristine‐growth‐inhibitory effects correlate with their retention by cultured Nb 2 node lymphoma cells
Banks et al. Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations
Nordlind et al. Mercuric chloride inhibition of leucocyte migration
Beleslin et al. Release of an unknown substance from brain structures of unanesthetized monkeys and cats
Matsuno et al. Assay of Anticoagulant Unit of ω-Heparin Newly Isolate from Whale's Lung and Intestine and its Toxicity
Sestier et al. In vitro toxicity of magnetic fluids evaluated for macrophage cell lines
Kirpotin et al. Magnetic targeting of a therapeutic antibody using magnetotropic microspheres of the interpolyelectrolyte coacervation complex
Ogino et al. Triphenyltin chloride induces glucose intolerance by the suppression of insulin release from hamster pancreatic ß-cells
Haapiainen et al. Pretreatment hormone levels in prostatic cancer
Tucker et al. Alterations in bone marrow cell cycle kinetics by diphenylhydantoin and folate deficiency are restored by thymic peptides
Kirschbaum et al. Reply to comment on the observation of enhanced peak responses due to solvent interactions
Booth et al. Radioprotective thiolamines WR-1065 and WR-33278 selectively denature nonhistone nuclear proteins
Hamilton et al. Medical and Health Physics Quarterly Report

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 656368

Country of ref document: ES