ES2130650T3 - Medios de contraste yodados para rayos x. - Google Patents

Medios de contraste yodados para rayos x.

Info

Publication number
ES2130650T3
ES2130650T3 ES95932108T ES95932108T ES2130650T3 ES 2130650 T3 ES2130650 T3 ES 2130650T3 ES 95932108 T ES95932108 T ES 95932108T ES 95932108 T ES95932108 T ES 95932108T ES 2130650 T3 ES2130650 T3 ES 2130650T3
Authority
ES
Spain
Prior art keywords
sub
group
fraction
groups
rays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95932108T
Other languages
English (en)
Inventor
Anna Rydbeck
Torsten Almen
Mikkel Thaning
Sven Andersson
Lars-Goran Wistrand
Klaes Golman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Application granted granted Critical
Publication of ES2130650T3 publication Critical patent/ES2130650T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Exposure And Positioning Against Photoresist Photosensitive Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Liquid Crystal (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

LA INVENCION PROPORCIONA COMPUESTOS BIS FENILO IODADOS, UTILES COMO AGENTES DE CONTRASTE DE RAYOS-X, DE FORMULA (I) (DONDE CADA FRACCION C{SUB,6}R{SUB,5}, PUEDE SER IGUAL O DISTINTA; CADA R REPRESENTA UN ATOMO DE HIDROGENO O IODO, O UN GRUPO M. DOS O TRES GRUPOS R NO ADYACENTES DE CADA FRACCION C{SUB,6}R{SUB,5}, REPRESENTAN GRUPOS M; X REPRESENTA UN GRUPO QUE PROPORCIONA UNA CADENA DE 1,2 O 3 ATOMOS, QUE UNE LOS DOS GRUPOS C{SUB,6}R{SUB,5}. PREFERIBLEMENTE X ES O CONTIENE EN LA CADENA PUENTE, UN GRUPO CARBONILOXI, SIENDO CADA GRUPO C{SUB,6}R{SUB,5} UN GRUPO TRIIODOFENILO O UN GRUPO DONDE CADA R ES DISTINTO DE HIDROGENO; Y CADA M ES, INDEPENDIENTEMENTE, UNA FRACCION HIDROFILICA, NO IONICA, Y CONTIENE PREFERIBLEMENTE UN GRUPO MONOHIDROXI- O POLIHIDROXI-ALQUILO). SE INCLUYEN ASIMISMO LOS ISOMEROS, PREFERIBLEMENTE ESTEREOISOMEROS Y ROTAMEROS, DE LOS MISMOS.
ES95932108T 1994-09-23 1995-09-22 Medios de contraste yodados para rayos x. Expired - Lifetime ES2130650T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9419206A GB9419206D0 (en) 1994-09-23 1994-09-23 Contrast media

Publications (1)

Publication Number Publication Date
ES2130650T3 true ES2130650T3 (es) 1999-07-01

Family

ID=10761799

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95932108T Expired - Lifetime ES2130650T3 (es) 1994-09-23 1995-09-22 Medios de contraste yodados para rayos x.

Country Status (21)

Country Link
US (2) US5958375A (es)
EP (1) EP0782565B1 (es)
JP (1) JP3606583B2 (es)
AT (1) ATE178592T1 (es)
AU (1) AU710934B2 (es)
CA (1) CA2200752A1 (es)
CZ (1) CZ89497A3 (es)
DE (2) DE69508949D1 (es)
DK (1) DK0782565T3 (es)
EE (1) EE9700054A (es)
ES (1) ES2130650T3 (es)
FI (1) FI971200A7 (es)
GB (1) GB9419206D0 (es)
GR (1) GR3030425T3 (es)
HU (1) HUT77170A (es)
MX (1) MX9702088A (es)
NO (1) NO971318L (es)
NZ (1) NZ292974A (es)
PL (1) PL319367A1 (es)
SK (1) SK35597A3 (es)
WO (1) WO1996009285A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
GB9710726D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Compound
ATE298320T1 (de) * 1999-04-30 2005-07-15 Amersham Health As Kontrastmittel
ES2314087T3 (es) 2001-03-08 2009-03-16 The Trustees Of The University Of Pennsylvania Polimeros facialmente anfifilicos como agentes antiinfecciosos.
WO2004082634A2 (en) 2003-03-17 2004-09-30 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers and oligomers and uses thereof
JP2011500770A (ja) * 2007-10-30 2011-01-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
US8445725B2 (en) 2008-01-14 2013-05-21 Mallinckrodt Llc Process for the preparation of iosimenol
JP5164755B2 (ja) * 2008-09-09 2013-03-21 キヤノン株式会社 ビス−アセチルアミノフェニル化合物の結晶の製造方法
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776241A (en) * 1952-08-06 1957-01-01 Schering Ag Injectable x-ray contrast agents comprising salts of n-acyl derivatives of 2, 4, 6-triiodo-3-aminobenzoic acid
US2708678A (en) * 1954-01-15 1955-05-17 Schering Corp Iodinated acyl derivatives of 2, 4, 6-trhodometa-aminobenzoic acid
GB1033777A (en) * 1963-06-06 1966-06-22 Sterling Drug Inc Bis-anilide derivatives
US3794729A (en) * 1971-07-16 1974-02-26 Schering Corp Inhibiting blood platelet aggregation
CH576255A5 (es) * 1972-11-17 1976-06-15 Bracco Ind Chimica Spa
DE2737802A1 (de) * 1977-08-22 1979-03-08 Henning Berlin Gmbh Arzneimittel oder diagnostikum zur behandlung oder feststellung von schilddruesenfunktionsstoerungen und verfahren zu dessen herstellung
DE3037858A1 (de) * 1980-10-07 1982-05-19 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von reaktiven, kupplungsfaehigen derivaten der schilddruesenhormone t (pfeil abwaerts)3(pfeil abwaerts) und t (pfeil abwaerts)4(pfeil abwaerts) und deren verwendung
CA1327600C (en) * 1987-05-22 1994-03-08 Ernest Felder Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
FR2673180B1 (fr) * 1991-02-25 1994-03-04 Guerbet Sa Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant.
FR2695125B1 (fr) * 1992-08-25 1994-12-23 Guerbet Sa Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant.
NZ250063A (en) * 1992-12-14 1996-03-26 Eastman Kodak Co Iodinated aromatic acid ester derivatives; x-ray contrast compositions
IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x

Also Published As

Publication number Publication date
ATE178592T1 (de) 1999-04-15
NO971318L (no) 1997-08-11
AU710934B2 (en) 1999-09-30
EP0782565A1 (en) 1997-07-09
US5958375A (en) 1999-09-28
MX9702088A (es) 1997-06-28
NZ292974A (en) 1999-03-29
CA2200752A1 (en) 1996-03-28
US5958376A (en) 1999-09-28
AU3529395A (en) 1996-04-09
DE69508949D1 (de) 1999-05-12
GR3030425T3 (en) 1999-09-30
PL319367A1 (en) 1997-08-04
EP0782565B1 (en) 1999-04-07
NO971318D0 (no) 1997-03-20
GB9419206D0 (en) 1994-11-09
DE69508949T2 (de) 1999-09-09
JPH10505856A (ja) 1998-06-09
EE9700054A (et) 1997-08-15
FI971200L (fi) 1997-05-19
JP3606583B2 (ja) 2005-01-05
SK35597A3 (en) 1997-11-05
FI971200A7 (fi) 1997-05-19
WO1996009285A1 (en) 1996-03-28
DK0782565T3 (da) 1999-10-18
CZ89497A3 (en) 1997-09-17
DE69508949T4 (de) 1999-12-09
HUT77170A (hu) 1998-03-02
FI971200A0 (fi) 1997-03-21

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