ES2130703T3 - Conjugados de benzodiazepinas y proteinas y su utilizacion para la determinacion inmunologica de benzodiazepinas. - Google Patents

Conjugados de benzodiazepinas y proteinas y su utilizacion para la determinacion inmunologica de benzodiazepinas.

Info

Publication number
ES2130703T3
ES2130703T3 ES96101315T ES96101315T ES2130703T3 ES 2130703 T3 ES2130703 T3 ES 2130703T3 ES 96101315 T ES96101315 T ES 96101315T ES 96101315 T ES96101315 T ES 96101315T ES 2130703 T3 ES2130703 T3 ES 2130703T3
Authority
ES
Spain
Prior art keywords
sub
benzodiazepines
conjugates
group
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96101315T
Other languages
English (en)
Inventor
Erasmus Dr Huber
Christian Dr Klein
Hans-Peter Dr Josel
Bruno Zink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Application granted granted Critical
Publication of ES2130703T3 publication Critical patent/ES2130703T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA INVENCION TRATA DE NUEVOS CONJUGADOS DE BENZODIAZEPINA Y PROTEINA DE FORMULA I, DONDE R{SUB,1} ES HIDROGENO, UN GRUPO METILO O R, R{SUB,2} ES HIDROGENO, HIDROXI O UN GRUPO-OR, DONDE O R{SUB,1} O R{SUB,2} CONTIENEN UN GRUPO-OR, R{SUB,3} ES HALOGENO, NO{SUB,2} O NH{SUB,2}, X ES HIDROGENO O HALOGENO, R ES UN GRUPO DE FORMULA II, DONDE Z ES UNA SUSTANCIA MACROMOLECULAR TRANSPORTADORA E INMUNOACTIVA, Y N = 2 O 3. LOS CONJUGADOS DE BENZODIAZEPINA Y PROTEINA SE UTILIZAN COMO INMUNOGENOS PARA OBTENER ANTICUERPOS CONTRA LA BENZODIAZEPINA. LA INVENCION TAMBIEN DESCRIBE UN INMUNOENSAYO PARA DETECTAR BENZODIAZEPINAS UTILIZANDO LOS ANTICUERPOS OBTENIDOS.
ES96101315T 1995-02-02 1996-01-31 Conjugados de benzodiazepinas y proteinas y su utilizacion para la determinacion inmunologica de benzodiazepinas. Expired - Lifetime ES2130703T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19503320A DE19503320A1 (de) 1995-02-02 1995-02-02 Neue Benzodiazepinkonjugate

Publications (1)

Publication Number Publication Date
ES2130703T3 true ES2130703T3 (es) 1999-07-01

Family

ID=7752966

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96101315T Expired - Lifetime ES2130703T3 (es) 1995-02-02 1996-01-31 Conjugados de benzodiazepinas y proteinas y su utilizacion para la determinacion inmunologica de benzodiazepinas.

Country Status (5)

Country Link
US (1) US5662911A (es)
EP (1) EP0726275B1 (es)
JP (1) JP2732825B2 (es)
DE (2) DE19503320A1 (es)
ES (1) ES2130703T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19927783A1 (de) * 1999-06-18 2000-12-21 Roche Diagnostics Gmbh Element zur Bestimmung eines Analyts in einer Flüssigkeit, entsprechendes Bestimmungsverfahren unter Verwendung des Elementes sowie Kit zur Bestimmugn eines Analyts
US7238533B1 (en) 2003-07-22 2007-07-03 Ronald Legge Personal illicit drug detection method
GB0401008D0 (en) * 2004-01-17 2004-02-18 Univ Manchester Drug delivery system
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
PT3056203T (pt) 2010-04-21 2018-02-15 Syntarga Bv Conjugados de análogos de cc-1065 e ligantes bifuncionais
CA2935433C (en) 2014-01-10 2019-04-02 Synthon Biopharmaceuticals B.V. Duocarmycin anti-her2 antibody drug conjucates with activity against her2 expressing malignancies
RU2686085C2 (ru) 2014-01-10 2019-04-24 Синтон Байофармасьютикалс Б. В. Конъюгаты антитело-лекарственное средство (adc) с дуокармицином, применяемые для лечения рака эндометрия
EP3197919A1 (en) * 2014-09-22 2017-08-02 Synthon Biopharmaceuticals B.V. Pan-reactive antibodies to duocarmycins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6347108D0 (pt) * 1962-03-02 1973-07-19 Hoffmann La Roche Processo para a preparacao de derivados de benzoiduazepina e seus sais
US4046636A (en) * 1974-06-20 1977-09-06 Syva Company Diazepam enzyme conjugates
ES2084577T3 (es) * 1986-10-24 1996-05-16 Abbott Lab Ensayo, trazadores, inmunogenos y anticuerpos para benzodiazepinas.
DE3919915A1 (de) * 1989-06-19 1990-12-20 Boehringer Mannheim Gmbh Aminoalkylmaleimide und davon abgeleitete hapten- und antigenderivate sowie konjugate mit peptiden oder proteinen
CA1335707C (en) * 1989-08-15 1995-05-30 Pyare Khanna Drug screening assay
US5302715A (en) * 1992-04-06 1994-04-12 Biosite Diagnostics, Inc. Benzodiazepine derivatives
WO1993023076A1 (en) * 1992-05-20 1993-11-25 The Johns-Hopkins University Alternative receptor therapy

Also Published As

Publication number Publication date
JP2732825B2 (ja) 1998-03-30
EP0726275A1 (de) 1996-08-14
US5662911A (en) 1997-09-02
DE19503320A1 (de) 1996-08-08
JPH08245689A (ja) 1996-09-24
EP0726275B1 (de) 1999-01-27
DE59601198D1 (de) 1999-03-11

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