ES2131219T3 - Solvatos estables de compuestos de avermectina. - Google Patents

Solvatos estables de compuestos de avermectina.

Info

Publication number
ES2131219T3
ES2131219T3 ES94931307T ES94931307T ES2131219T3 ES 2131219 T3 ES2131219 T3 ES 2131219T3 ES 94931307 T ES94931307 T ES 94931307T ES 94931307 T ES94931307 T ES 94931307T ES 2131219 T3 ES2131219 T3 ES 2131219T3
Authority
ES
Spain
Prior art keywords
avermectin compounds
avermectin
compounds
disclosed
solvates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94931307T
Other languages
English (en)
Inventor
Joseph S Amato
Raymond Cvetovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2131219T3 publication Critical patent/ES2131219T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • External Artificial Organs (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)

Abstract

SE PRESENTA UNA NUEVA FORMA DE COMPUESTOS DE AVERMECTINA EN LA QUE LOS COMPUESTOS DE AVERMECTINA SE CRISTALIZAN COMO SOLVATOS DE ALCOHOL PARA MEJORAR GRATAMENTE LA ESTABILIDAD DE LA DROGA DE AVERMECTINA DURANTE SU ALMACENAMIENTO A LARGO PLAZO. LOS COMPUESTOS DE AVERMECTINA TIENEN UTILIDAD COMO AGENTES ANTIPARASITICOS, INSECTICIDAS Y ANTIHELMINTICOS ALTAMENTE POTENTES Y TAMBIEN SE PRESENTAN COMPOSICIONES PARA ESTOS USOS.
ES94931307T 1993-10-08 1994-10-04 Solvatos estables de compuestos de avermectina. Expired - Lifetime ES2131219T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/133,494 US5380838A (en) 1993-10-08 1993-10-08 Stable solvates of avermectin compounds

Publications (1)

Publication Number Publication Date
ES2131219T3 true ES2131219T3 (es) 1999-07-16

Family

ID=22458871

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94931307T Expired - Lifetime ES2131219T3 (es) 1993-10-08 1994-10-04 Solvatos estables de compuestos de avermectina.

Country Status (10)

Country Link
US (1) US5380838A (es)
EP (1) EP0722454B1 (es)
JP (1) JP2938974B2 (es)
AT (1) ATE179985T1 (es)
AU (1) AU681916B2 (es)
CA (1) CA2171871C (es)
DE (1) DE69418469T2 (es)
ES (1) ES2131219T3 (es)
WO (1) WO1995010525A1 (es)
ZA (1) ZA947863B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716567D0 (en) * 1997-08-05 1997-10-08 Pfizer Process
CA2309350C (en) 1997-11-12 2007-04-03 Mitsubishi Chemical Corporation Purine derivatives and medicaments comprising the same as active ingredient
CN1160355C (zh) 1999-05-11 2004-08-04 三菱化学株式会社 嘌呤衍生物二水合物、含有该化合物作为有效成分的药物及其制备中间体
WO2004063147A1 (en) * 2003-01-10 2004-07-29 Novo Nordisk A/S Salts and solvates of glucagon antagonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
NZ188459A (en) * 1977-10-03 1982-09-07 Merck & Co Inc Derivatives of c-076 compounds and pesticidal compositions
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4206205A (en) * 1977-10-03 1980-06-03 Merck & Co., Inc. Monosaccharide and aglycone derivatives of C-076
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
US4734375A (en) * 1980-05-27 1988-03-29 Miles Laboratories, Inc. Ion specific test method
US4457920A (en) * 1981-09-03 1984-07-03 Merck & Co., Inc. 4a-Substituted avermectin compounds
US4657854A (en) * 1983-05-05 1987-04-14 Ivan Endre Modrovich Assay systems based on magnesium-responsive enzymes
DE3669515D1 (de) * 1985-09-13 1990-04-19 Biotechnolog Forschung Gmbh Makrozyklische antibiotika.
US4812400A (en) * 1986-07-14 1989-03-14 Steinman Gary D Process for measuring sodium levels in biological fluids
JPH0612999B2 (ja) * 1986-11-17 1994-02-23 関東化学株式会社 塩素イオン定量用試薬

Also Published As

Publication number Publication date
US5380838A (en) 1995-01-10
DE69418469D1 (de) 1999-06-17
JPH09503521A (ja) 1997-04-08
ATE179985T1 (de) 1999-05-15
JP2938974B2 (ja) 1999-08-25
EP0722454B1 (en) 1999-05-12
AU8013094A (en) 1995-05-04
ZA947863B (en) 1995-05-22
CA2171871A1 (en) 1995-04-20
AU681916B2 (en) 1997-09-11
CA2171871C (en) 1999-08-03
EP0722454A1 (en) 1996-07-24
WO1995010525A1 (en) 1995-04-20
DE69418469T2 (de) 1999-12-16

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