ES2131578T3 - Deteccion rapida de resistencia a antibioticos en mycobacterium tuberculosis. - Google Patents

Deteccion rapida de resistencia a antibioticos en mycobacterium tuberculosis.

Info

Publication number
ES2131578T3
ES2131578T3 ES93909875T ES93909875T ES2131578T3 ES 2131578 T3 ES2131578 T3 ES 2131578T3 ES 93909875 T ES93909875 T ES 93909875T ES 93909875 T ES93909875 T ES 93909875T ES 2131578 T3 ES2131578 T3 ES 2131578T3
Authority
ES
Spain
Prior art keywords
resistance
mycobacterium tuberculosis
antibiotic resistance
rapid detection
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93909875T
Other languages
English (en)
Other versions
ES2131578T5 (es
Inventor
Beate Heym
Stewart Cole
Douglas Young
Ying Zhang
Nadine Honore
Amalio Telenti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Bern
Universite Pierre et Marie Curie
Assistance Publique Hopitaux de Paris APHP
Institut Pasteur
Medical Research Council
Original Assignee
Universitaet Bern
Universite Pierre et Marie Curie
Assistance Publique Hopitaux de Paris APHP
Institut Pasteur
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27446863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2131578(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/929,206 external-priority patent/US5633131A/en
Priority claimed from FR9211098A external-priority patent/FR2695650B1/fr
Priority claimed from FR9304545A external-priority patent/FR2704002B1/fr
Application filed by Universitaet Bern, Universite Pierre et Marie Curie, Assistance Publique Hopitaux de Paris APHP, Institut Pasteur, Medical Research Council filed Critical Universitaet Bern
Publication of ES2131578T3 publication Critical patent/ES2131578T3/es
Application granted granted Critical
Publication of ES2131578T5 publication Critical patent/ES2131578T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LAS CEPAS RESISTENTES A DROGAS MULTIPLES DEL "MYCOBACTERIUM TUBERCULOSIS" REPRESENTAN UNA AMENAZA CONSIDERABLE PARA LA SALUD HUMANA A LO LARGO DEL MUNDO. FRECUENTEMENTE SE NECESITA DETECTAR LA RESISTENCIA AL ISONIAZID (INH), A LA RIFAMPICINA O A ANALOGOS DE LA MISMA, O LA ESTREPTOMICINA, POR EJEMPLO COMPONENTES CLAVE DE REGIMENES ANTITUBERCULOSIS. LA INVENCION COMPRENDE LA DETECCION DE UNA MUTACION EN EL GEN KATG (RESISTENCIA AL ISONAZID) O EN EL GEN RPOB (RESISTENCIA A LA RIFAMPICINA) O EN EL GEN RPSL (RESISTENCIA A LA ESTREPTOMICINA).
ES93909875T 1992-04-30 1993-04-30 Deteccion rapida de resistencia a antibioticos en mycobacterium tuber culosis. Expired - Lifetime ES2131578T5 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US87594092A 1992-04-30 1992-04-30
US875940 1992-04-30
US07/929,206 US5633131A (en) 1992-04-30 1992-08-14 Rapid detection of isoniazid resistance in mycobacterium tuberculosis probes for selecting nucleic acid encoding isoniazid resistance, and methods and kits
US929206 1992-08-14
FR9211098 1992-09-17
FR9211098A FR2695650B1 (fr) 1992-09-17 1992-09-17 Procédé de détection de la résistance des mycobactéries à la rifampicine; kit de diagnostic pour la mise en Óoeuvre.
FR9304545A FR2704002B1 (fr) 1993-04-16 1993-04-16 Methode de detection de la resistance des mycobacteries a la streptomycine, kit de diagnostic pour la mise en oeuvre et sequence nucleotidique du gene rpsl de mycobacterium tuberculosis.
FR9304545 1993-04-16

Publications (2)

Publication Number Publication Date
ES2131578T3 true ES2131578T3 (es) 1999-08-01
ES2131578T5 ES2131578T5 (es) 2010-03-31

Family

ID=27446863

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93909875T Expired - Lifetime ES2131578T5 (es) 1992-04-30 1993-04-30 Deteccion rapida de resistencia a antibioticos en mycobacterium tuber culosis.

Country Status (9)

Country Link
EP (1) EP0639229B2 (es)
JP (3) JP3579049B2 (es)
AT (1) ATE177476T1 (es)
CA (1) CA2134103C (es)
DE (1) DE69323872T3 (es)
DK (1) DK0639229T4 (es)
ES (1) ES2131578T5 (es)
GR (1) GR3030479T3 (es)
WO (1) WO1993022454A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2162868A1 (en) * 1993-05-13 1994-11-24 William R. Jacobs, Jr. Methods and compositions for detecting and treating mycobacterial infections using an inha gene
US5610012A (en) * 1994-04-08 1997-03-11 Wisconsin Alumni Research Foundation DNA probes specific for virulent listeria monocytogenes
US5658733A (en) * 1994-04-18 1997-08-19 Mayo Foundation For Medical Education And Research Detection of isoniazid resistant strains of M. tuberculosis
US5922575A (en) * 1994-04-18 1999-07-13 Mayo Foundation For Medical Education & Research Mutations in the katG gene useful for detection of M. tuberculosis
US5688639A (en) * 1994-04-18 1997-11-18 Mayo Foundation For Medical Education And Research Detection of isoniazid resistent strains of M. tuberculosis
GB9506658D0 (en) * 1995-03-31 1995-05-24 Gatsby Charitable Foundation Plant pathogen resistance genes and uses thereof
US5643723A (en) * 1994-05-26 1997-07-01 Roche Molecular Systems, Inc. Detection of a genetic locus encoding resistance to rifampin in mycobacterial cultures and in clinical specimens
CA2192364C (en) 1994-06-09 2009-01-20 Hans De Beenhouwer Method for the detection of the antibiotic resistance spectrum of mycobacterium species
US5712095A (en) * 1994-06-16 1998-01-27 Becton Dickinson And Company Rapid and sensitive detection of antibiotic-resistant mycobacteria using oligonucleotide probes specific for ribosomal RNA precursors
US6287865B1 (en) 1995-03-31 2001-09-11 Plant Bioscience Limited Cf-2 plant pathogen resistance genes
FR2738827B1 (fr) * 1995-09-18 1997-10-17 Bio Merieux Detection des enterobacteries
US5939300A (en) * 1996-07-03 1999-08-17 Diversa Corporation Catalases
US6284466B1 (en) 1998-09-18 2001-09-04 The Board Of Regents Of University Of Nebraska Method of detecting genetic polymorphisms using over represented sequences
WO2002066651A2 (en) * 2001-02-16 2002-08-29 Degussa Ag Nucleotide sequences of the ribosomal protein s12 gene (rpsl) from corynebacterium glutamicum
EP1239040A3 (de) * 2001-02-16 2003-01-08 Degussa AG Mutationen im rpoB-Gen L-Lysin produzierender Corynebacterium glutamicum-Stämme und Verfahren zur Herstellung von L-Lysin
KR100454585B1 (ko) * 2001-10-09 2004-11-02 주식회사 에스제이하이테크 마이코박테리아의 균주 감별, 결핵균의 스트레인 감별과항생제 내성을 검출하기 위한 프로브를 포함하는마이크로어레이와 이를 이용한 검출 방법 및 진단 키트
RU2376387C2 (ru) * 2005-12-26 2009-12-20 Учреждение Российской академии наук Институт молекулярной биологии им. В.А. Энгельгардта РАН Способ одновременного обнаружения микобактерий туберкулезного комплекса и идентификации мутаций в днк микобактерий, приводящих к устойчивости микроорганизмов к рифампицину и изониазиду, на биологических микрочипах, набор праймеров, биочип и набор олигонуклеотидных зондов, используемые в способе
CN102105596A (zh) 2008-07-02 2011-06-22 尼普洛株式会社 用于检测结核杆菌中的异烟肼敏感性的方法和试验片
BRPI0913658B1 (pt) 2008-07-02 2019-06-25 Nipro Corporation Método, tira de teste e kit para detecção da sensibilidade à isoniazida em mycobacterium tuberculosis
CA2788080C (en) * 2010-01-26 2018-04-17 Meiji Seika Pharma Co., Ltd. Nucleic acid construct comprising pyripyropene biosynthetic gene cluster and marker gene
CN112823004A (zh) 2018-06-06 2021-05-18 米尼奥尔克斯治疗有限公司 5-[[4-[2-[5-乙酰基吡啶-2-基]乙氧基]苄基]-1,3-噻唑烷-2,4-二酮及其盐的用途
CN111517947B (zh) * 2020-03-18 2022-05-24 西北师范大学 一种基于功能化的双边柱[5]芳烃传感器分子及其合成和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0223156B1 (en) * 1985-11-12 1991-05-22 Hoechst Japan Limited Streptomycin sensitive gene having a lot of cloning sites, plasmid vector containing the same and microorganism containing the vector
GB8924989D0 (en) * 1989-11-06 1989-12-28 Scotgen Ltd Method and device for the detection of antibiotic resistance

Also Published As

Publication number Publication date
CA2134103C (en) 2010-06-22
EP0639229B2 (en) 2009-11-25
WO1993022454A1 (en) 1993-11-11
JP2004000136A (ja) 2004-01-08
JP3579049B2 (ja) 2004-10-20
DK0639229T3 (da) 1999-09-27
DE69323872T2 (de) 1999-09-30
ATE177476T1 (de) 1999-03-15
DE69323872D1 (de) 1999-04-15
CA2134103A1 (en) 1993-11-11
JP2004154125A (ja) 2004-06-03
EP0639229B1 (en) 1999-03-10
JPH07506003A (ja) 1995-07-06
JP3905064B2 (ja) 2007-04-18
DK0639229T4 (da) 2010-03-01
ES2131578T5 (es) 2010-03-31
EP0639229A1 (en) 1995-02-22
DE69323872T3 (de) 2010-06-02
JP3818652B2 (ja) 2006-09-06
GR3030479T3 (en) 1999-10-29

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